Human Gene ID1 (ENST00000376112.4_9) from GENCODE V47lift37
  Description: inhibitor of DNA binding 1, HLH protein, transcript variant 1 (from RefSeq NM_002165.4)
Gencode Transcript: ENST00000376112.4_9
Gencode Gene: ENSG00000125968.10_12
Transcript (Including UTRs)
   Position: hg19 chr20:30,193,092-30,194,313 Size: 1,222 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr20:30,193,191-30,193,897 Size: 707 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:30,193,092-30,194,313)mRNA (may differ from genome)Protein (155 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ID1_HUMAN
DESCRIPTION: RecName: Full=DNA-binding protein inhibitor ID-1; AltName: Full=Class B basic helix-loop-helix protein 24; Short=bHLHb24; AltName: Full=Inhibitor of DNA binding 1;
FUNCTION: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding.
SUBUNIT: Heterodimer with other HLH proteins. Interacts with COPS5 (By similarity).
INTERACTION: O14936:CASK; NbExp=3; IntAct=EBI-1215527, EBI-1215506; Q03135:CAV1; NbExp=6; IntAct=EBI-1215527, EBI-603614;
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus.
DEVELOPMENTAL STAGE: Expression correlates with proliferation in some types of cells.
SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ID1
Diseases sorted by gene-association score: salivary gland cancer (3), multicentric castleman disease (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 356.16 RPKM in Bladder
Total median expression: 3034.16 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -8.9099-0.090 Picture PostScript Text
3' UTR -142.90416-0.344 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026052 - DNA-bd_prot-inh
IPR011598 - HLH_dom

Pfam Domains:
PF00010 - Helix-loop-helix DNA-binding domain

SCOP Domains:
47459 - HLH, helix-loop-helix DNA-binding domain

ModBase Predicted Comparative 3D Structure on P41134
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0042803 protein homodimerization activity
GO:0043621 protein self-association
GO:0046983 protein dimerization activity
GO:0047485 protein N-terminus binding
GO:0070628 proteasome binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001525 angiogenesis
GO:0001886 endothelial cell morphogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007275 multicellular organism development
GO:0007420 brain development
GO:0007507 heart development
GO:0007623 circadian rhythm
GO:0010621 negative regulation of transcription by transcription factor localization
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0014070 response to organic cyclic compound
GO:0030182 neuron differentiation
GO:0030509 BMP signaling pathway
GO:0031648 protein destabilization
GO:0032091 negative regulation of protein binding
GO:0032233 positive regulation of actin filament bundle assembly
GO:0032963 collagen metabolic process
GO:0036164 cell-abiotic substrate adhesion
GO:0043066 negative regulation of apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0043408 regulation of MAPK cascade
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043534 blood vessel endothelial cell migration
GO:0045602 negative regulation of endothelial cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045765 regulation of angiogenesis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046677 response to antibiotic
GO:0048511 rhythmic process
GO:0048514 blood vessel morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050774 negative regulation of dendrite morphogenesis
GO:0060425 lung morphogenesis
GO:0060426 lung vasculature development
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0090074 negative regulation of protein homodimerization activity
GO:1901342 regulation of vasculature development
GO:1901653 cellular response to peptide
GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
GO:1903351 cellular response to dopamine
GO:1990090 cellular response to nerve growth factor stimulus

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005813 centrosome


-  Descriptions from all associated GenBank mRNAs
  KJ897027 - Synthetic construct Homo sapiens clone ccsbBroadEn_06421 ID1 gene, encodes complete protein.
LF205959 - JP 2014500723-A/13462: Polycomb-Associated Non-Coding RNAs.
AK313786 - Homo sapiens cDNA, FLJ94396.
JB837392 - Sequence 3 from Patent WO2013106494.
JB837393 - Sequence 4 from Patent WO2013106494.
BC012420 - Homo sapiens inhibitor of DNA binding 1, dominant negative helix-loop-helix protein, mRNA (cDNA clone MGC:9178 IMAGE:3862019), complete cds.
JD061340 - Sequence 42364 from Patent EP1572962.
LF213706 - JP 2014500723-A/21209: Polycomb-Associated Non-Coding RNAs.
BC000613 - Homo sapiens inhibitor of DNA binding 1, dominant negative helix-loop-helix protein, mRNA (cDNA clone MGC:1717 IMAGE:3346009), complete cds.
S78986 - Id1 (Id1-a)=transcription regulator helix-loop-helix protein {alternatively spliced} [human, glioblastoma cell line U251, mRNA Partial, 530 nt].
X77956 - H.sapiens Id1 mRNA.
AK291152 - Homo sapiens cDNA FLJ76404 complete cds, highly similar to Homo sapiens inhibitor of DNA binding 1, dominant negative helix-loop-helix protein (ID1), transcript variant 1, mRNA.
D13890 - Homo sapiens mRNA for Id-1H', complete cds.
E07537 - Human Id gene(Id-1H').
D13889 - Homo sapiens mRNA for Id-1H, complete cds.
E07536 - Human Id gene(Id-1H).
S78825 - Id1 (Id1-b)=transcription regulator helix-loop-helix protein {alternatively spliced} [human, glioblastoma cell line U251, mRNA, 1146 nt].
CU680316 - Synthetic construct Homo sapiens gateway clone IMAGE:100017939 5' read ID1 mRNA.
AB463776 - Synthetic construct DNA, clone: pF1KB9682, Homo sapiens ID1 gene for inhibitor of DNA binding 1, dominant negative helix-loop-helix protein, without stop codon, in Flexi system.
DQ891293 - Synthetic construct clone IMAGE:100003923; FLH170809.01X; RZPDo839B10100D inhibitor of DNA binding 1, dominant negative helix-loop-helix protein (ID1) gene, encodes complete protein.
DQ893342 - Synthetic construct clone IMAGE:100005972; FLH196422.01X; RZPDo839D01156D inhibitor of DNA binding 1, dominant negative helix-loop-helix protein (ID1) gene, encodes complete protein.
DQ894477 - Synthetic construct Homo sapiens clone IMAGE:100008937; FLH170805.01L; RZPDo839B1099D inhibitor of DNA binding 1, dominant negative helix-loop-helix protein (ID1) gene, encodes complete protein.
DQ896657 - Synthetic construct Homo sapiens clone IMAGE:100011117; FLH263616.01L; RZPDo839C04155D inhibitor of DNA binding 1, dominant negative helix-loop-helix protein (ID1) gene, encodes complete protein.
EU176458 - Synthetic construct Homo sapiens clone IMAGE:100006634; FLH264111.01X; RZPDo839D09257D inhibitor of DNA binding 1, dominant negative helix-loop-helix protein (ID1) gene, encodes complete protein.
EU176468 - Synthetic construct Homo sapiens clone IMAGE:100006565; FLH263588.01X; RZPDo839D05153D inhibitor of DNA binding 1, dominant negative helix-loop-helix protein (ID1) gene, encodes complete protein.
EU176808 - Synthetic construct Homo sapiens clone IMAGE:100011572; FLH263593.01L; RZPDo839D12252D inhibitor of DNA binding 1, dominant negative helix-loop-helix protein (ID1) gene, encodes complete protein.
BT007443 - Homo sapiens inhibitor of DNA binding 1, dominant negative helix-loop-helix protein mRNA, complete cds.
LF350135 - JP 2014500723-A/157638: Polycomb-Associated Non-Coding RNAs.
JD060140 - Sequence 41164 from Patent EP1572962.
JD423134 - Sequence 404158 from Patent EP1572962.
JD537967 - Sequence 518991 from Patent EP1572962.
JD461580 - Sequence 442604 from Patent EP1572962.
JD137212 - Sequence 118236 from Patent EP1572962.
JD454612 - Sequence 435636 from Patent EP1572962.
JD517765 - Sequence 498789 from Patent EP1572962.
JD544181 - Sequence 525205 from Patent EP1572962.
JD485084 - Sequence 466108 from Patent EP1572962.
JD138724 - Sequence 119748 from Patent EP1572962.
JD101125 - Sequence 82149 from Patent EP1572962.
LF350136 - JP 2014500723-A/157639: Polycomb-Associated Non-Coding RNAs.
MA585712 - JP 2018138019-A/157638: Polycomb-Associated Non-Coding RNAs.
MA585713 - JP 2018138019-A/157639: Polycomb-Associated Non-Coding RNAs.
MA441536 - JP 2018138019-A/13462: Polycomb-Associated Non-Coding RNAs.
MA449283 - JP 2018138019-A/21209: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P41134 (Reactome details) participates in the following event(s):

R-HSA-3209165 ID1 sequesters ETS2
R-HSA-2559585 Oncogene Induced Senescence
R-HSA-2559583 Cellular Senescence
R-HSA-2262752 Cellular responses to stress
R-HSA-8953897 Cellular responses to external stimuli

-  Other Names for This Gene
  Alternate Gene Symbols: A8K537, BHLHB24, E1P5L4, ENST00000376112.1, ENST00000376112.2, ENST00000376112.3, ID, ID1_HUMAN, NM_002165, O00651, O00652, P41134, Q16371, Q16377, Q5TE66, Q5TE67, Q969Z7, Q9H0Z5, Q9H109, uc318msy.1, uc318msy.2
UCSC ID: ENST00000376112.4_9
RefSeq Accession: NM_002165.4
Protein: P41134 (aka ID1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.