Human Gene ID2 (ENST00000396290.2_5) from GENCODE V47lift37
  Description: inhibitor of DNA binding 2 (from RefSeq NM_002166.5)
Gencode Transcript: ENST00000396290.2_5
Gencode Gene: ENSG00000115738.10_8
Transcript (Including UTRs)
   Position: hg19 chr2:8,822,186-8,824,591 Size: 2,406 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr2:8,822,296-8,823,029 Size: 734 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:8,822,186-8,824,591)mRNA (may differ from genome)Protein (134 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCHuman Cortex Gene ExpressionMalacardsMGIOMIMPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q53T66_HUMAN
DESCRIPTION: SubName: Full=Cell growth-inhibiting gene 8; SubName: Full=Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, isoform CRA_a; SubName: Full=Putative uncharacterized protein ID2; SubName: Full=cDNA, FLJ92261, highly similar to Homo sapiens inhibitor of DNA binding 2, dominant negative helix-loop-helix protein (ID2), mRNA;
SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ID2
Diseases sorted by gene-association score: ewing sarcoma (3), diamond-blackfan anemia (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 248.21 RPKM in Artery - Tibial
Total median expression: 2084.58 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -41.10110-0.374 Picture PostScript Text
3' UTR -166.00784-0.212 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026052 - DNA-bd_prot-inh
IPR011598 - HLH_dom

Pfam Domains:
PF00010 - Helix-loop-helix DNA-binding domain

SCOP Domains:
47459 - HLH, helix-loop-helix DNA-binding domain

ModBase Predicted Comparative 3D Structure on Q53T66
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0046983 protein dimerization activity

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001656 metanephros development
GO:0001779 natural killer cell differentiation
GO:0001966 thigmotaxis
GO:0002521 leukocyte differentiation
GO:0003149 membranous septum morphogenesis
GO:0003166 bundle of His development
GO:0007507 heart development
GO:0007623 circadian rhythm
GO:0008344 adult locomotory behavior
GO:0009649 entrainment of circadian clock
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0014003 oligodendrocyte development
GO:0019216 regulation of lipid metabolic process
GO:0021772 olfactory bulb development
GO:0032922 circadian regulation of gene expression
GO:0033598 mammary gland epithelial cell proliferation
GO:0042752 regulation of circadian rhythm
GO:0043153 entrainment of circadian clock by photoperiod
GO:0043353 enucleate erythrocyte differentiation
GO:0043392 negative regulation of DNA binding
GO:0045475 locomotor rhythm
GO:0045578 negative regulation of B cell differentiation
GO:0045600 positive regulation of fat cell differentiation
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045651 positive regulation of macrophage differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045777 positive regulation of blood pressure
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048468 cell development
GO:0048469 cell maturation
GO:0048541 Peyer's patch development
GO:0048557 embryonic digestive tract morphogenesis
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048663 neuron fate commitment
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048711 positive regulation of astrocyte differentiation
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0060612 adipose tissue development
GO:0060749 mammary gland alveolus development
GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development
GO:0061031 endodermal digestive tract morphogenesis
GO:0071158 positive regulation of cell cycle arrest
GO:0071285 cellular response to lithium ion
GO:0090398 cellular senescence
GO:2000178 negative regulation of neural precursor cell proliferation

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0032991 macromolecular complex


-  Descriptions from all associated GenBank mRNAs
  LQ270680 - Sequence 8 from Patent WO2016071350.
JB837394 - Sequence 5 from Patent WO2013106494.
LQ270676 - Sequence 4 from Patent WO2016071350.
AY634687 - Homo sapiens cell growth-inhibiting gene 8 (GIG8) mRNA, complete cds.
AK222682 - Homo sapiens mRNA for inhibitor of DNA binding 2 variant, clone: CBR03716.
M97796 - Human helix-loop-helix protein (Id-2) mRNA, complete cds.
BC030639 - Homo sapiens inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, mRNA (cDNA clone MGC:26389 IMAGE:4820416), complete cds.
AK311988 - Homo sapiens cDNA, FLJ92261, highly similar to Homo sapiens inhibitor of DNA binding 2, dominant negative helix-loop-helix protein (ID2), mRNA.
D13891 - Homo sapiens mRNA for Id-2H, complete cds.
KJ891421 - Synthetic construct Homo sapiens clone ccsbBroadEn_00815 ID2 gene, encodes complete protein.
KJ904909 - Synthetic construct Homo sapiens clone ccsbBroadEn_14303 ID2B gene, encodes complete protein.
DQ894013 - Synthetic construct Homo sapiens clone IMAGE:100008473; FLH166548.01L; RZPDo839A0487D inhibitor of DNA binding 2, dominant negative helix-loop-helix protein (ID2) gene, encodes complete protein.
AB463777 - Synthetic construct DNA, clone: pF1KB8870, Homo sapiens ID2 gene for inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, without stop codon, in Flexi system.
DQ890858 - Synthetic construct clone IMAGE:100003488; FLH166552.01X; RZPDo839A0488D inhibitor of DNA binding 2, dominant negative helix-loop-helix protein (ID2) gene, encodes complete protein.
JD262893 - Sequence 243917 from Patent EP1572962.
JD292309 - Sequence 273333 from Patent EP1572962.
JD048399 - Sequence 29423 from Patent EP1572962.
LQ932417 - Sequence 8 from Patent WO2014187881.
LQ932413 - Sequence 4 from Patent WO2014187881.

-  Other Names for This Gene
  Alternate Gene Symbols: D6W4Y7, ENST00000396290.1, GIG8 , hCG_1784377 , ID2 , NM_002166, Q53T66, Q53T66_HUMAN, uc318ydi.1, uc318ydi.2
UCSC ID: ENST00000396290.2_5
RefSeq Accession: NM_002166.5
Protein: Q53T66

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.