ID:ID3_HUMAN DESCRIPTION: RecName: Full=DNA-binding protein inhibitor ID-3; AltName: Full=Class B basic helix-loop-helix protein 25; Short=bHLHb25; AltName: Full=Helix-loop-helix protein HEIR-1; AltName: Full=ID-like protein inhibitor HLH 1R21; AltName: Full=Inhibitor of DNA binding 3; FUNCTION: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-3 inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. May inhibit other transcription factors. SUBUNIT: Interacts with COPS5 and COPS7A (By similarity). Homodimer, and heterodimer with other HLH proteins. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain. INDUCTION: By phorbol 12-myristate 13-acetate (PMA). SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain. SEQUENCE CAUTION: Sequence=CAA47360.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q02535
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003714 transcription corepressor activity GO:0005515 protein binding GO:0008134 transcription factor binding GO:0019904 protein domain specific binding GO:0046983 protein dimerization activity GO:1901707 leptomycin B binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001656 metanephros development GO:0006275 regulation of DNA replication GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0007275 multicellular organism development GO:0007417 central nervous system development GO:0007507 heart development GO:0007517 muscle organ development GO:0007623 circadian rhythm GO:0009611 response to wounding GO:0010629 negative regulation of gene expression GO:0030182 neuron differentiation GO:0030855 epithelial cell differentiation GO:0030903 notochord development GO:0042476 odontogenesis GO:0043065 positive regulation of apoptotic process GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0045662 negative regulation of myoblast differentiation GO:0045668 negative regulation of osteoblast differentiation GO:0045892 negative regulation of transcription, DNA-templated GO:0048511 rhythmic process GO:0051726 regulation of cell cycle GO:0072750 cellular response to leptomycin B
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
