ID:IDE_HUMAN DESCRIPTION: RecName: Full=Insulin-degrading enzyme; EC=3.4.24.56; AltName: Full=Abeta-degrading protease; AltName: Full=Insulin protease; Short=Insulinase; AltName: Full=Insulysin; FUNCTION: Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. CATALYTIC ACTIVITY: Degradation of insulin, glucagon and other polypeptides. No action on proteins. COFACTOR: Binds 1 zinc ion per subunit. ENZYME REGULATION: Activated by small peptides (By similarity). Activated by ATP and GTP, and to a lesser extent by CTP, TTP and PPPi. Inhibited by bacitracin. Inhibited by S-nitrosylation and oxidation agents. SUBUNIT: Homodimer. Can form higher oligomers. Interacts (via N- terminus) with varicella-zoster virus (VZV) envelope glycoprotein E (via N-terminus); the membrane-associated isoform may function as an entry receptor for this virus. SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Secreted (By similarity). Note=Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform. DOMAIN: The SlyX motif may be involved in the non-conventional secretion of the protein (By similarity). PTM: The N-terminus is blocked. MISCELLANEOUS: ATP-binding induces a conformation change. SIMILARITY: Belongs to the peptidase M16 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P14735
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006508 proteolysis GO:0006625 protein targeting to peroxisome GO:0008152 metabolic process GO:0008286 insulin receptor signaling pathway GO:0008340 determination of adult lifespan GO:0010815 bradykinin catabolic process GO:0010992 ubiquitin homeostasis GO:0016032 viral process GO:0032461 positive regulation of protein oligomerization GO:0042447 hormone catabolic process GO:0044257 cellular protein catabolic process GO:0045732 positive regulation of protein catabolic process GO:0045861 negative regulation of proteolysis GO:0046718 viral entry into host cell GO:0050435 beta-amyloid metabolic process GO:0051260 protein homooligomerization GO:0051289 protein homotetramerization GO:0051291 protein heterooligomerization GO:0051603 proteolysis involved in cellular protein catabolic process GO:0097242 beta-amyloid clearance GO:1901142 insulin metabolic process GO:1901143 insulin catabolic process
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
