ID:IDHC_HUMAN DESCRIPTION: RecName: Full=Isocitrate dehydrogenase [NADP] cytoplasmic; Short=IDH; EC=1.1.1.42; AltName: Full=Cytosolic NADP-isocitrate dehydrogenase; AltName: Full=IDP; AltName: Full=NADP(+)-specific ICDH; AltName: Full=Oxalosuccinate decarboxylase; CATALYTIC ACTIVITY: Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH. COFACTOR: Binds 1 magnesium or manganese ion per subunit. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=49 uM for NADP; KM=29 uM for magnesium chloride; KM=65 uM for isocitrate; SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. Peroxisome. DISEASE: Defects in IDH1 are involved in the development of glioma (GLM) [MIM:137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Mutations affecting Arg-132 are tissue-specific, and suggest that this residue plays a unique role in the development of high-grade gliomas. Mutations of Arg-132 to Cys, His, Leu or Ser abolish magnesium binding and abolish the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate. Elevated levels of R(-)-2- hydroxyglutarate are correlated with an elevated risk of malignant brain tumors. SIMILARITY: Belongs to the isocitrate and isopropylmalate dehydrogenases family. WEB RESOURCE: Name=Wikipedia; Note=Isocitrate dehydrogenase entry; URL="http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75874
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000287 magnesium ion binding GO:0004448 isocitrate dehydrogenase activity GO:0004450 isocitrate dehydrogenase (NADP+) activity GO:0005102 receptor binding GO:0016491 oxidoreductase activity GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0042802 identical protein binding GO:0042803 protein homodimerization activity GO:0045296 cadherin binding GO:0046872 metal ion binding GO:0050661 NADP binding GO:0051287 NAD binding GO:0051990 (R)-2-hydroxyglutarate dehydrogenase activity
Biological Process: GO:0006097 glyoxylate cycle GO:0006099 tricarboxylic acid cycle GO:0006102 isocitrate metabolic process GO:0006103 2-oxoglutarate metabolic process GO:0006625 protein targeting to peroxisome GO:0006740 NADPH regeneration GO:0006749 glutathione metabolic process GO:0006979 response to oxidative stress GO:0008585 female gonad development GO:0014070 response to organic cyclic compound GO:0043312 neutrophil degranulation GO:0048545 response to steroid hormone GO:0055114 oxidation-reduction process GO:0060696 regulation of phospholipid catabolic process GO:0071071 regulation of phospholipid biosynthetic process
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
