ID:I23O1_HUMAN DESCRIPTION: RecName: Full=Indoleamine 2,3-dioxygenase 1; Short=IDO-1; EC=1.13.11.52; AltName: Full=Indoleamine-pyrrole 2,3-dioxygenase; FUNCTION: Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. CATALYTIC ACTIVITY: D-tryptophan + O(2) = N-formyl-D-kynurenine. CATALYTIC ACTIVITY: L-tryptophan + O(2) = N-formyl-L-kynurenine. COFACTOR: Binds 1 heme group per subunit. ENZYME REGULATION: Activity is inhibited by and MTH-trp (methylthiohydantoin-DL-tryptophan), modestly inhibited by L-1MT (1-methyl-L-tryptophan) but not D-1MT (1-methyl-D-tryptophan). BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=21.23 uM for L-tryptophan; KM=4.6 mM for D-tryptophan; Note=Catalytic efficiency for L-tryptophan is 150 times higher than for D-tryptophan; PATHWAY: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. INDUCTION: By IFNG/IFN-gamma. SIMILARITY: Belongs to the indoleamine 2,3-dioxygenase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P14902
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002376 immune system process GO:0002534 cytokine production involved in inflammatory response GO:0002666 positive regulation of T cell tolerance induction GO:0002678 positive regulation of chronic inflammatory response GO:0002830 positive regulation of type 2 immune response GO:0006569 tryptophan catabolic process GO:0006954 inflammatory response GO:0007565 female pregnancy GO:0019441 tryptophan catabolic process to kynurenine GO:0022900 electron transport chain GO:0032496 response to lipopolysaccharide GO:0032693 negative regulation of interleukin-10 production GO:0032735 positive regulation of interleukin-12 production GO:0033555 multicellular organismal response to stress GO:0034276 kynurenic acid biosynthetic process GO:0036269 swimming behavior GO:0042130 negative regulation of T cell proliferation GO:0043065 positive regulation of apoptotic process GO:0055114 oxidation-reduction process GO:0070233 negative regulation of T cell apoptotic process GO:0070234 positive regulation of T cell apoptotic process GO:0046006 regulation of activated T cell proliferation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
