Human Gene IER5L (ENST00000372491.4_6) from GENCODE V47lift37
  Description: immediate early response 5 like (from RefSeq NM_203434.3)
Gencode Transcript: ENST00000372491.4_6
Gencode Gene: ENSG00000188483.8_8
Transcript (Including UTRs)
   Position: hg19 chr9:131,937,831-131,940,540 Size: 2,710 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr9:131,939,117-131,940,331 Size: 1,215 Coding Exon Count: 1 

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RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:131,937,831-131,940,540)mRNA (may differ from genome)Protein (404 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: IER5L_HUMAN
DESCRIPTION: RecName: Full=Immediate early response gene 5-like protein;
SIMILARITY: Belongs to the IER family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.68 RPKM in Cervix - Endocervix
Total median expression: 385.11 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -102.90209-0.492 Picture PostScript Text
3' UTR -488.201286-0.380 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008653 - IER

Pfam Domains:
PF05760 - Immediate early response protein (IER)

ModBase Predicted Comparative 3D Structure on Q5T953
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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 RGDEnsembl   
      
      

-  Descriptions from all associated GenBank mRNAs
  JD324702 - Sequence 305726 from Patent EP1572962.
JD177817 - Sequence 158841 from Patent EP1572962.
JD133329 - Sequence 114353 from Patent EP1572962.
BC013070 - Homo sapiens immediate early response 5-like, mRNA (cDNA clone IMAGE:4149891), with apparent retained intron.
BC064028 - Homo sapiens immediate early response 5-like, mRNA (cDNA clone MGC:70833 IMAGE:6526871), complete cds.
JD074632 - Sequence 55656 from Patent EP1572962.
JD465897 - Sequence 446921 from Patent EP1572962.
JD023449 - Sequence 4473 from Patent EP1572962.
JD033491 - Sequence 14515 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000372491.1, ENST00000372491.2, ENST00000372491.3, IER5L_HUMAN, NM_203434, Q5T953, Q6P3E2, uc318jyu.1, uc318jyu.2
UCSC ID: ENST00000372491.4_6
RefSeq Accession: NM_203434.3
Protein: Q5T953 (aka IER5L_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.