Human Gene IFIT3 (ENST00000371811.4_2) from GENCODE V47lift37
  Description: interferon induced protein with tetratricopeptide repeats 3, transcript variant 2 (from RefSeq NM_001031683.4)
Gencode Transcript: ENST00000371811.4_2
Gencode Gene: ENSG00000119917.15_10
Transcript (Including UTRs)
   Position: hg19 chr10:91,092,241-91,100,728 Size: 8,488 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr10:91,092,380-91,099,885 Size: 7,506 Coding Exon Count: 2 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:91,092,241-91,100,728)mRNA (may differ from genome)Protein (490 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 82.74 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 412.47 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -21.60139-0.155 Picture PostScript Text
3' UTR -245.90843-0.292 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024122 - Interferon-induced_IFIT3
IPR001440 - TPR-1
IPR013026 - TPR-contain_dom
IPR011990 - TPR-like_helical
IPR019734 - TPR_repeat

Pfam Domains:
PF01535 - PPR repeat
PF13174 - Tetratricopeptide repeat
PF13176 - Tetratricopeptide repeat
PF13181 - Tetratricopeptide repeat
PF13424 - Tetratricopeptide repeat

SCOP Domains:
81901 - HCP-like
48439 - Protein prenylyltransferase
48452 - TPR-like

ModBase Predicted Comparative 3D Structure on Q5T765
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0035457 cellular response to interferon-alpha

Cellular Component:
GO:0005739 mitochondrion
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  LP895789 - Sequence 653 from Patent EP3253886.
AK290427 - Homo sapiens cDNA FLJ75638 complete cds, highly similar to Homo sapiens interferon-induced protein with tetratricopeptide repeats 3 (IFIT3), mRNA.
LF211307 - JP 2014500723-A/18810: Polycomb-Associated Non-Coding RNAs.
AF083470 - Homo sapiens interferon induced tetratricopeptide protein IFI60 (IFIT4) mRNA, complete cds.
AK312675 - Homo sapiens cDNA, FLJ93068.
U52513 - Human RIG-G mRNA, complete cds.
AK297137 - Homo sapiens cDNA FLJ53454 complete cds, highly similar to Interferon-induced protein with tetratricopeptide repeats 3.
AF026939 - Homo sapiens CIG49 (cig49) mRNA, complete cds.
BC001383 - Homo sapiens interferon-induced protein with tetratricopeptide repeats 3, mRNA (cDNA clone MGC:2046 IMAGE:3050764), complete cds.
BC004977 - Homo sapiens interferon-induced protein with tetratricopeptide repeats 3, mRNA (cDNA clone MGC:3834 IMAGE:2906188), complete cds.
MA446884 - JP 2018138019-A/18810: Polycomb-Associated Non-Coding RNAs.
CU678838 - Synthetic construct Homo sapiens gateway clone IMAGE:100020262 5' read IFIT3 mRNA.
CU674680 - Synthetic construct Homo sapiens gateway clone IMAGE:100017362 5' read IFIT3 mRNA.
AB464597 - Synthetic construct DNA, clone: pF1KB7047, Homo sapiens IFIT3 gene for interferon-induced protein with tetratricopeptide repeats 3, without stop codon, in Flexi system.
BT007284 - Homo sapiens interferon-induced protein with tetratricopeptide repeats 4 mRNA, complete cds.
JF432276 - Synthetic construct Homo sapiens clone IMAGE:100073448 interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) gene, encodes complete protein.
KJ897033 - Synthetic construct Homo sapiens clone ccsbBroadEn_06427 IFIT3 gene, encodes complete protein.
KJ897034 - Synthetic construct Homo sapiens clone ccsbBroadEn_06428 IFIT3 gene, encodes complete protein.
LF345456 - JP 2014500723-A/152959: Polycomb-Associated Non-Coding RNAs.
LF345457 - JP 2014500723-A/152960: Polycomb-Associated Non-Coding RNAs.
LF345458 - JP 2014500723-A/152961: Polycomb-Associated Non-Coding RNAs.
JD019803 - Sequence 827 from Patent EP1572962.
JD034685 - Sequence 15709 from Patent EP1572962.
JD021658 - Sequence 2682 from Patent EP1572962.
JD035217 - Sequence 16241 from Patent EP1572962.
LF345459 - JP 2014500723-A/152962: Polycomb-Associated Non-Coding RNAs.
LF345460 - JP 2014500723-A/152963: Polycomb-Associated Non-Coding RNAs.
JD211745 - Sequence 192769 from Patent EP1572962.
JD144693 - Sequence 125717 from Patent EP1572962.
JD143716 - Sequence 124740 from Patent EP1572962.
JD529616 - Sequence 510640 from Patent EP1572962.
JD170093 - Sequence 151117 from Patent EP1572962.
JD170094 - Sequence 151118 from Patent EP1572962.
JD306965 - Sequence 287989 from Patent EP1572962.
JD322748 - Sequence 303772 from Patent EP1572962.
JD400370 - Sequence 381394 from Patent EP1572962.
JD400371 - Sequence 381395 from Patent EP1572962.
JD177542 - Sequence 158566 from Patent EP1572962.
AF026943 - Homo sapiens cig41 mRNA, partial sequence.
MA581033 - JP 2018138019-A/152959: Polycomb-Associated Non-Coding RNAs.
MA581034 - JP 2018138019-A/152960: Polycomb-Associated Non-Coding RNAs.
MA581035 - JP 2018138019-A/152961: Polycomb-Associated Non-Coding RNAs.
MA581036 - JP 2018138019-A/152962: Polycomb-Associated Non-Coding RNAs.
MA581037 - JP 2018138019-A/152963: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000371811.1, ENST00000371811.2, ENST00000371811.3, hCG_24570 , IFIT3 , NM_001031683, Q5T765, Q5T765_HUMAN, uc318jkp.1
UCSC ID: ENST00000371811.4_2
RefSeq Accession: NM_001031683.4
Protein: Q5T765

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.