Human Gene IFNA2 (ENST00000380206.4_6) from GENCODE V47lift37

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Description: interferon alpha 2 (from RefSeq NM_000605.4)
Gencode Transcript: ENST00000380206.4_6
Gencode Gene: ENSG00000188379.7_8
Transcript (Including UTRs)
Position: hg19 chr9:21,384,254-21,385,397 Size: 1,144 Total Exon Count: 1 Strand: -
Coding Region
Position: hg19 chr9:21,384,762-21,385,328 Size: 567 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr9:21,384,254-21,385,397)			mRNA (may differ from genome)		Protein (188 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
Malacards	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: IFNA2_HUMAN DESCRIPTION: RecName: Full=Interferon alpha-2; Short=IFN-alpha-2; AltName: Full=Interferon alpha-A; Short=LeIF A; Flags: Precursor; FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities. SUBUNIT: Interacts with IFNAR2. SUBCELLULAR LOCATION: Secreted. POLYMORPHISM: Three forms exist; alpha-2a (shown here), alpha-2b and alpha-2c. PHARMACEUTICAL: Available under the names Roferon-A (Roche) or Intron-A (Schering-Plough). Used as an anticancer drug for its antiproliferative activity. SIMILARITY: Belongs to the alpha/beta interferon family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: IFNA2 Diseases sorted by gene-association score: peyronie's disease (36), hepatitis c (35), hepatitis b (32), hepatitis d (28), lymphomatoid granulomatosis (24), discoid lupus erythematosus (23), viral hepatitis (23), cryoglobulinemia (21), stomatitis (20), hepatitis (19), kaposi sarcoma (18), hemangioma-thrombocytopenia syndrome (18), necrobiotic xanthogranuloma (18), cutaneous polyarteritis nodosa (18), angiosarcoma of the scalp (18), conjunctival cancer (17), hairy cell leukemia (16), penile disease (16), mast cell disease (16), polyarteritis nodosa (16), follicular mucinosis (15), squamous papillomatosis (15), conjunctival deposit (14), conjunctival pigmentation (14), systemic mastocytosis (13), myeloproliferative disorder with eosinophilia (13), aggressive systemic mastocytosis (13), conjunctival intraepithelial neoplasm (11), sarcomatoid renal cell carcinoma (10), angioma, tufted (10), conjunctival squamous cell carcinoma (10), essential thrombocythemia (10), splenomegaly (10), kidney cancer (10), uveitis (10), transitional cell carcinoma (9), mycosis fungoides (9), malignant conjunctival melanoma (9), c1q deficiency (9), lymphangioma (9), malignant skin fibrous histiocytoma (8), malignant dermis tumor (8), granulomatous hepatitis (8), hemangioma of liver (8), orbital plasma cell granuloma (8), herpes zoster (8), chronic orbital inflammation (8), penile cancer (8), recurrent respiratory papillomatosis (8), viral infectious disease (8), thrombocytopenic purpura, autoimmune (8), gorham's disease (7), cryoglobulinemia, familial mixed (7), spinocerebellar ataxia, autosomal recessive 10 (7), giant hemangioma (7), st. louis encephalitis (7), muir-torre syndrome (7), leukemia, chronic myeloid, somatic (7), chronic neutrophilic leukemia (7), polycythemia vera, somatic (6), orchitis (6), dysentery (6), polyneuropathy (6), punctate epithelial keratoconjunctivitis (6), pyoderma (6), pyoderma gangrenosum (6), common cold (6), ovarian cystic teratoma (6), hepatitis a (6), vogt-koyanagi-harada disease (5), carcinoid syndrome (5), phlebotomus fever (5), serotonin syndrome (5), myelofibrosis with myeloid metaplasia, somatic (4), adenosquamous pancreas carcinoma (4), behcet syndrome (4), vasculitis (3), renal cell carcinoma (3), acne (3), acquired immunodeficiency syndrome (3), colorectal cancer (2), urinary bladder cancer (2), hepatocellular carcinoma (2), malignant melanoma, somatic (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C032668 1-nitropyrene D015073 2-Acetylaminofluorene D000535 Aluminum D000584 Amiloride D000643 Ammonium Chloride D002087 Butyrates D003513 Cycloheximide D003606 Dacarbazine D004052 Diethylnitrosamine D004281 Docosahexaenoic Acids more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 2.26 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 2.97 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-16.70	69	-0.242	Picture	PostScript	Text
3' UTR	-83.70	508	-0.165	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR009079 - 4_helix_cytokine-like_core
IPR012351 - 4_helix_cytokine_core
IPR015589 - Interferon_alpha
IPR000471 - Interferon_alpha/beta/delta

Pfam Domains:
PF00143 - Interferon alpha/beta domain

SCOP Domains:
47266 - 4-helical cytokines
53137 - Translational machinery components

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1ITF - NMR

1RH2 - X-ray

2HIE - Model

2HYM - NMR MuPIT

2KZ1 - NMR MuPIT

2LAG - NMR MuPIT

3S9D - X-ray MuPIT

3SE3 - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on P01563


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
	Gene Details
	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005132 type I interferon receptor binding GO:0005515 protein binding Biological Process: GO:0002286 T cell activation involved in immune response GO:0002323 natural killer cell activation involved in immune response GO:0006915 apoptotic process GO:0006952 defense response GO:0006954 inflammatory response GO:0006959 humoral immune response GO:0007166 cell surface receptor signaling pathway GO:0007267 cell-cell signaling GO:0007596 blood coagulation GO:0010469 regulation of receptor activity GO:0010629 negative regulation of gene expression GO:0019221 cytokine-mediated signaling pathway GO:0030183 B cell differentiation GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0042100 B cell proliferation GO:0042327 positive regulation of phosphorylation GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0043330 response to exogenous dsRNA GO:0045087 innate immune response GO:0045581 negative regulation of T cell differentiation GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0046597 negative regulation of viral entry into host cell GO:0051607 defense response to virus GO:0060337 type I interferon signaling pathway GO:2000552 negative regulation of T-helper 2 cell cytokine production GO:2000663 negative regulation of interleukin-5 secretion GO:2000666 negative regulation of interleukin-13 secretion Cellular Component: GO:0005576 extracellular region GO:0005615 extracellular space

Descriptions from all associated GenBank mRNAs


	KJ891428 - Synthetic construct Homo sapiens clone ccsbBroadEn_00822 IFNA2 gene, encodes complete protein. E00099 - DNA coding of interferon(HLyc IFN-4(1)). E00172 - cDNA encoding human interferon-1(1). JD268229 - Sequence 249253 from Patent EP1572962. M54886 - Human interferon-alpha mRNA, complete cds. V00544 - Messenger RNA for human leukocyte interferon. E00032 - DNA coding of human leukocyte interferon A(LeIF A). E00043 - DNA coding of LeIF A. E00471 - Human leukocyte interferon A (LeIF A) gene and its flanking sequence. E00473 - Human leukocyte interferon A (LeIFA) gene and its flanking sequence. V00549 - Messenger RNA for human leukocyte (alpha) interferon. V00548 - Homo sapiens partial mRNA for interferon alpha-2 precursor (IFNA2 gene). BC104163 - Homo sapiens interferon, alpha 2, mRNA (cDNA clone MGC:125764 IMAGE:40029595), complete cds. BC104164 - Homo sapiens interferon, alpha 2, mRNA (cDNA clone MGC:125765 IMAGE:40029596), complete cds. JD093652 - Sequence 74676 from Patent EP1572962. BC074936 - Homo sapiens interferon, alpha 2, mRNA (cDNA clone MGC:103885 IMAGE:30915269), complete cds. BC074937 - Homo sapiens interferon, alpha 2, mRNA (cDNA clone MGC:104046 IMAGE:30915492), complete cds. JN591568 - Homo sapiens clone IAS1 interferon alpha 2b (IFNA2B) mRNA, complete cds. JN591569 - Homo sapiens clone IAS2 interferon alpha 2b (IFNA2B) mRNA, complete cds. JN591570 - Homo sapiens clone IAS3 interferon alpha 2b (IFNA2B) mRNA, complete cds. JN848522 - Homo sapiens interferon alpha 2a mRNA, complete cds. KY780371 - Homo sapiens interferon alpha 2b mRNA, complete cds. LQ884075 - Sequence 22 from Patent WO2018160540. AB590747 - Synthetic construct DNA, clone: pFN21AE1670, Homo sapiens IFNA2 gene for interferon, alpha 2, without stop codon, in Flexi system. CR541921 - Homo sapiens full open reading frame cDNA clone RZPDo834E0933D for gene IFNA2, interferon, alpha 2; complete cds, without stopcodon. AY255838 - Homo sapiens interferon alpha 2b mRNA, complete cds. MP518003 - Sequence 22 from Patent WO2020041655.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein P01563 (Reactome details) participates in the following event(s): R-HSA-909720 IFN alpha/beta binds to IFNAR2 R-HSA-909732 Phosphorylation of STAT2 R-HSA-909719 Recruitment of STAT2 to p-IFNAR1 R-HSA-909726 Phosphorylation of STAT1 R-HSA-909722 Release of p-STAT2:p-STAT1 dimer R-HSA-997309 Dephosphorylation of STAT1 by SHP2 R-HSA-909724 Recruitment of IFNAR1 R-HSA-909730 Phosphorylation of INFAR1 by TYK2 R-HSA-997311 Dephosphorylation of TYK2 by PTP1B R-HSA-909729 Activation of JAK kinases R-HSA-912680 Inhibition of JAK kinase activity by SOCS1/3 R-HSA-997314 Dephosphorylation of JAK1 by SHP1 R-HSA-909718 Formation of p-STAT1 homodimer R-HSA-909733 Interferon alpha/beta signaling R-HSA-933541 TRAF6 mediated IRF7 activation R-HSA-983231 Factors involved in megakaryocyte development and platelet production R-HSA-912694 Regulation of IFNA signaling R-HSA-913531 Interferon Signaling R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-109582 Hemostasis R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-168249 Innate Immune System R-HSA-168256 Immune System

Other Names for This Gene


	Alternate Gene Symbols: ENST00000380206.1, ENST00000380206.2, ENST00000380206.3, H2DF54, H2DF55, IFNA2A, IFNA2B, IFNA2C, IFNA2_HUMAN, NM_000605, P01563, P01564, Q14606, Q6DJX8, Q96KI6, uc318pli.1, uc318pli.2 UCSC ID: ENST00000380206.4_6 RefSeq Accession: NM_000605.4 Protein: P01563 (aka IFNA2_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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