Human Gene IFNA5 (ENST00000610521.2_5) from GENCODE V47lift37

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Description: interferon alpha 5 (from RefSeq NM_002169.3)
Gencode Transcript: ENST00000610521.2_5
Gencode Gene: ENSG00000147873.6_6
Transcript (Including UTRs)
Position: hg19 chr9:21,304,325-21,305,312 Size: 988 Total Exon Count: 1 Strand: -
Coding Region
Position: hg19 chr9:21,304,686-21,305,255 Size: 570 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions	Pathways
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr9:21,304,325-21,305,312)			mRNA (may differ from genome)		Protein (189 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
MGI	OMIM	PubMed	Reactome	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: IFNA5_HUMAN DESCRIPTION: RecName: Full=Interferon alpha-5; Short=IFN-alpha-5; AltName: Full=Interferon alpha-61; AltName: Full=Interferon alpha-G; Short=LeIF G; Flags: Precursor; FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the alpha/beta interferon family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C009505 4,4'-diaminodiphenylmethane D010081 Oxazolone C004984 apocarotenal D019207 beta Carotene C008776 pelargonic acid C076994 perfluorooctane sulfonic acid C023036 perfluorooctanoic acid

Common Gene Haplotype Alleles


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-9.00	57	-0.158	Picture	PostScript	Text
3' UTR	-46.00	361	-0.127	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR009079 - 4_helix_cytokine-like_core
IPR012351 - 4_helix_cytokine_core
IPR015589 - Interferon_alpha
IPR000471 - Interferon_alpha/beta/delta

Pfam Domains:
PF00143 - Interferon alpha/beta domain

SCOP Domains:
47266 - 4-helical cytokines

ModBase Predicted Comparative 3D Structure on P01569


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005132 type I interferon receptor binding Biological Process: GO:0002250 adaptive immune response GO:0002286 T cell activation involved in immune response GO:0002323 natural killer cell activation involved in immune response GO:0006952 defense response GO:0006959 humoral immune response GO:0007596 blood coagulation GO:0010469 regulation of receptor activity GO:0019221 cytokine-mediated signaling pathway GO:0030183 B cell differentiation GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0042100 B cell proliferation GO:0043330 response to exogenous dsRNA GO:0045087 innate immune response GO:0051607 defense response to virus GO:0060337 type I interferon signaling pathway Cellular Component: GO:0005576 extracellular region GO:0005615 extracellular space

Descriptions from all associated GenBank mRNAs


	KJ891430 - Synthetic construct Homo sapiens clone ccsbBroadEn_00824 IFNA5 gene, encodes complete protein. E00124 - DNA coding of alpha-interferon Gx-1. E00049 - DNA coding of LeIF G. V00541 - Messenger RNA for human leukocyte interferon (one of eight). BC093755 - Homo sapiens interferon, alpha 5, mRNA (cDNA clone MGC:120790 IMAGE:7939600), complete cds. BC093757 - Homo sapiens interferon, alpha 5, mRNA (cDNA clone MGC:120792 IMAGE:7939602), complete cds.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein P01569 (Reactome details) participates in the following event(s): R-HSA-909720 IFN alpha/beta binds to IFNAR2 R-HSA-909732 Phosphorylation of STAT2 R-HSA-909719 Recruitment of STAT2 to p-IFNAR1 R-HSA-909726 Phosphorylation of STAT1 R-HSA-909722 Release of p-STAT2:p-STAT1 dimer R-HSA-997309 Dephosphorylation of STAT1 by SHP2 R-HSA-909724 Recruitment of IFNAR1 R-HSA-909730 Phosphorylation of INFAR1 by TYK2 R-HSA-997311 Dephosphorylation of TYK2 by PTP1B R-HSA-909729 Activation of JAK kinases R-HSA-912680 Inhibition of JAK kinase activity by SOCS1/3 R-HSA-997314 Dephosphorylation of JAK1 by SHP1 R-HSA-909718 Formation of p-STAT1 homodimer R-HSA-909733 Interferon alpha/beta signaling R-HSA-933541 TRAF6 mediated IRF7 activation R-HSA-983231 Factors involved in megakaryocyte development and platelet production R-HSA-912694 Regulation of IFNA signaling R-HSA-913531 Interferon Signaling R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-109582 Hemostasis R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-168249 Innate Immune System R-HSA-168256 Immune System

Other Names for This Gene


	Alternate Gene Symbols: ENST00000610521.1, IFNA5_HUMAN, NM_002169, P01569, Q52LX3, uc327muy.1, uc327muy.2 UCSC ID: ENST00000610521.2_5 RefSeq Accession: NM_002169.3 Protein: P01569 (aka IFNA5_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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