ID:INAR2_HUMAN DESCRIPTION: RecName: Full=Interferon alpha/beta receptor 2; Short=IFN-R-2; Short=IFN-alpha binding protein; Short=IFN-alpha/beta receptor 2; AltName: Full=Interferon alpha binding protein; AltName: Full=Type I interferon receptor 2; Flags: Precursor; FUNCTION: Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. SUBUNIT: Heterodimer with IFNAR1; in presence of interferon alpha and/or beta ligands forms the type I interferon receptor. Isoform 1 interacts with the transcriptional factors STAT1 and STAT2. Interacts with JAK1. INTERACTION: Q92793:CREBBP; NbExp=4; IntAct=EBI-958408, EBI-81215; P63244:GNB2L1; NbExp=4; IntAct=EBI-958408, EBI-296739; Q00978:IRF9; NbExp=6; IntAct=EBI-958408, EBI-626526; P52630:STAT2; NbExp=2; IntAct=EBI-958408, EBI-1546963; SUBCELLULAR LOCATION: Isoform 1: Membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Isoform 2: Membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Isoform 3: Secreted. TISSUE SPECIFICITY: Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines. PTM: Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types. PTM: Glycosylated. POLYMORPHISM: Genetic variations in IFNAR2 influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424]. SIMILARITY: Belongs to the type II cytokine receptor family. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/ifnar2/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P48551
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004905 type I interferon receptor activity GO:0005515 protein binding GO:0019901 protein kinase binding GO:0019962 type I interferon binding
Biological Process: GO:0007166 cell surface receptor signaling pathway GO:0007259 JAK-STAT cascade GO:0009615 response to virus GO:0035455 response to interferon-alpha GO:0035456 response to interferon-beta GO:0051607 defense response to virus GO:0060337 type I interferon signaling pathway GO:0060338 regulation of type I interferon-mediated signaling pathway
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
