Human Gene IFNB1 (ENST00000380232.4_6) from GENCODE V47lift37
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Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: IFNB_HUMAN
DESCRIPTION: RecName: Full=Interferon beta; Short=IFN-beta; AltName: Full=Fibroblast interferon; Flags: Precursor;
FUNCTION: Has antiviral, antibacterial and anticancer activities. SUBUNIT: Monomer. SUBCELLULAR LOCATION: Secreted. PHARMACEUTICAL: Available under the names Avonex (Biogen), Betaseron (Berlex) and Rebif (Serono). Used in the treatment of multiple sclerosis (MS). Betaseron is a slightly modified form of IFNB1 with two residue substitutions. SIMILARITY: Belongs to the alpha/beta interferon family. WEB RESOURCE: Name=Avonex; Note=Clinical information on Avonex; URL="http://www.avonex.com/index.xml"; WEB RESOURCE: Name=Betaseron; Note=Clinical information on Betaseron; URL="http://www.betaseron.com/home";
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Primer design for this transcript
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MalaCards Disease Associations
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MalaCards Gene Search: IFNB1
Diseases sorted by gene-association score: relapsing-remitting multiple sclerosis (41), primary progressive multiple sclerosis (32), newcastle disease (28), secondary progressive multiple sclerosis (20), hepatitis c (19), oral erosive lichen (18), demyelinating disease (17), viral infectious disease (16), multiple sclerosis, disease progression, modifier of (14), kaposi sarcoma (14), parainfluenza virus type 3 (13), measles (11), spinal cord melanoma (10), marburg hemorrhagic fever (10), venezuelan equine encephalitis (10), severe acute respiratory syndrome (9), anogenital venereal wart (9), balo concentric sclerosis (9), japanese encephalitis (9), retroperitoneal neuroblastoma (9), chronic inflammatory demyelinating polyradiculoneuropathy (8), molluscum contagiosum (8), zika fever (7), influenza (6), retinal vasculitis (6), mucinoses (6), septicemic plague (6), herpes simplex (6), pedophilia (6), pseudo-torch syndrome 1 (6), microphthalmia with limb anomalies (6), listeria meningitis (5), internuclear ophthalmoplegia (5), respiratory syncytial virus infectious disease (5), pneumatosis cystoides intestinalis (4), ocular hyperemia (4), extrinsic cardiomyopathy (4), cerebral primitive neuroectodermal tumor (4), breast abscess (4), spinal cord astrocytoma (4), neuroretinitis (4), chilblain lupus (4), vaccinia (4), la crosse encephalitis (4), paraphilia disorder (4), gliosarcoma (4), malignant skin fibrous histiocytoma (3), multiple cranial nerve palsy (3), malignant glioma (3), nervous system disease (2), central nervous system disease (2)
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Comparative Toxicogenomics Database (CTD)
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The following chemicals interact with this gene
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Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure IPR009079 - 4_helix_cytokine-like_core
IPR012351 - 4_helix_cytokine_core
IPR000471 - Interferon_alpha/beta/delta
IPR015588 - Interferon_beta
Pfam Domains: PF00143 - Interferon alpha/beta domain
SCOP Domains: 47060 - S15/NS1 RNA-binding domain
47266 - 4-helical cytokines
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on P01574
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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E00017 - DNA coding for human interferon beta. M28622 - Human interferon beta-1 (IFN-beta-1) mRNA, complete cds. E00098 - DNA coding of interferon(HLyc IFN-betaI). E00171 - cDNA encoding human interferon-beta-1. V00546 - Messenger RNA for human fibroblast interferon. M25460 - Human interferon-beta mRNA, complete cds. V00547 - Human messenger RNA for fibroblast (beta) interferon. BC096151 - Homo sapiens interferon, beta 1, fibroblast, mRNA (cDNA clone MGC:116799 IMAGE:40002941), complete cds. BC096153 - Homo sapiens interferon, beta 1, fibroblast, mRNA (cDNA clone MGC:116801 IMAGE:40002945), complete cds. BC069314 - Homo sapiens interferon, beta 1, fibroblast, mRNA (cDNA clone MGC:96956 IMAGE:7262165), complete cds. BC096152 - Homo sapiens interferon, beta 1, fibroblast, mRNA (cDNA clone MGC:116800 IMAGE:40002943), complete cds. BC096150 - Homo sapiens interferon, beta 1, fibroblast, mRNA (cDNA clone MGC:116798 IMAGE:40002940), complete cds. JD374495 - Sequence 355519 from Patent EP1572962. E00029 - DNA coding of interferon beta. E00198 - cDNA encoding mutain of human IFN-beta. AB451491 - Homo sapiens IFNB1 mRNA for interferon beta precursor, partial cds, clone: FLJ08204DABN. AB451323 - Homo sapiens IFNB1 mRNA for interferon beta precursor, complete cds, clone: FLJ08204AAAN. KJ891438 - Synthetic construct Homo sapiens clone ccsbBroadEn_00832 IFNB1 gene, encodes complete protein. AB451452 - Homo sapiens IFNB1 mRNA for interferon beta precursor, partial cds, clone: FLJ08204AAAF. AB587428 - Synthetic construct DNA, clone: pF1KB6826, Homo sapiens IFNB1 gene for interferon, beta 1, fibroblast, without stop codon, in Flexi system. A00119 - H.sapiens mRNA for fibroblast interferon (partial). M17373 - Human interferon-beta (IFN-beta) mRNA, 5' UTR.
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Biochemical and Signaling Pathways
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Other Names for This Gene
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Alternate Gene Symbols: ENST00000380232.1, ENST00000380232.2, ENST00000380232.3, IFB, IFNB, IFNB1 , IFNB_HUMAN, NM_002176, P01574, Q5VWC9, uc318plu.1, uc318plu.2 UCSC ID: ENST00000380232.4_6 RefSeq Accession: NM_002176.4
Protein: P01574
(aka IFNB_HUMAN)
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Gene Model Information
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
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