ID:IL29_HUMAN DESCRIPTION: RecName: Full=Interleukin-29; Short=IL-29; AltName: Full=Cytokine Zcyto21; AltName: Full=Interferon lambda-1; Short=IFN-lambda-1; Flags: Precursor; FUNCTION: Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. SUBCELLULAR LOCATION: Secreted. INDUCTION: By viral infections or double-stranded RNA. SIMILARITY: Belongs to the IL-28/IL-29 family. WEB RESOURCE: Name=Wikipedia; Note=Interleukin-29 entry; URL="http://en.wikipedia.org/wiki/Interleukin_29";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IU54
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002829 negative regulation of type 2 immune response GO:0007259 JAK-STAT cascade GO:0008285 negative regulation of cell proliferation GO:0010469 regulation of receptor activity GO:0019221 cytokine-mediated signaling pathway GO:0032696 negative regulation of interleukin-13 production GO:0032714 negative regulation of interleukin-5 production GO:0032729 positive regulation of interferon-gamma production GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0043381 negative regulation of memory T cell differentiation GO:0045087 innate immune response GO:0045345 positive regulation of MHC class I biosynthetic process GO:0045581 negative regulation of T cell differentiation GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0046427 positive regulation of JAK-STAT cascade GO:0050778 positive regulation of immune response GO:0051607 defense response to virus
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
