Human Gene IFNLR1 (ENST00000327535.6_7) from GENCODE V47lift37
  Description: interferon lambda receptor 1, transcript variant 1 (from RefSeq NM_170743.4)
Gencode Transcript: ENST00000327535.6_7
Gencode Gene: ENSG00000185436.12_9
Transcript (Including UTRs)
   Position: hg19 chr1:24,480,658-24,513,779 Size: 33,122 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr1:24,483,620-24,513,738 Size: 30,119 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:24,480,658-24,513,779)mRNA (may differ from genome)Protein (520 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: I28RA_HUMAN
DESCRIPTION: RecName: Full=Interleukin-28 receptor subunit alpha; Short=IL-28 receptor subunit alpha; Short=IL-28R-alpha; Short=IL-28RA; AltName: Full=Cytokine receptor class-II member 12; AltName: Full=Cytokine receptor family 2 member 12; Short=CRF2-12; AltName: Full=Interferon lambda receptor 1; Short=IFN-lambda receptor 1; Short=IFN-lambda-R1; AltName: Full=Likely interleukin or cytokine receptor 2; Short=LICR2; Flags: Precursor;
FUNCTION: The IL28RA/IL10RB dimer is a receptor for IL28A, IL28B and IL29. The ligand/receptor complex seems to signal through the Jak-STAT pathway.
SUBUNIT: Heterodimer with IL10RB.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity).
TISSUE SPECIFICITY: Widely expressed.
SIMILARITY: Belongs to the type II cytokine receptor family.
SIMILARITY: Contains 1 fibronectin type-III domain.
SEQUENCE CAUTION: Sequence=BAD18707.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.87 RPKM in Pituitary
Total median expression: 64.95 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -19.0041-0.463 Picture PostScript Text
3' UTR -1049.002962-0.354 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003961 - Fibronectin_type3
IPR013783 - Ig-like_fold

Pfam Domains:
PF01108 - Tissue factor

SCOP Domains:
49265 - Fibronectin type III

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3OG4 - X-ray MuPIT 3OG6 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q8IU57
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004896 cytokine receptor activity
GO:0005515 protein binding

Biological Process:
GO:0002385 mucosal immune response
GO:0008285 negative regulation of cell proliferation
GO:0019221 cytokine-mediated signaling pathway
GO:0034342 response to type III interferon
GO:0050691 regulation of defense response to virus by host
GO:0051607 defense response to virus

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032002 interleukin-28 receptor complex


-  Descriptions from all associated GenBank mRNAs
  AF439325 - Homo sapiens putative class II cytokine receptor CRF2/12 (CRF2/12) mRNA, complete cds.
AK160364 - Homo sapiens mRNA for FLJ00190 protein.
BC140872 - Homo sapiens interleukin 28 receptor, alpha (interferon, lambda receptor), mRNA (cDNA clone MGC:176549 IMAGE:9021740), complete cds.
AJ534330 - Homo sapiens mRNA for Likely Interleukin or Cytokine Receptor 2 (LICR2 gene).
AJ534331 - Homo sapiens mRNA for soluble isoform of Likely Interleukin or Cytokine Receptor 2 (LICR2 gene).
AY129151 - Homo sapiens interleukin 28 receptor A (IL28RA) mRNA, complete cds; alternatively spliced.
AY129152 - Homo sapiens interleukin 28 receptor A splice variant 2 (IL28RA) mRNA, complete cds; alternatively spliced.
JN591376 - Homo sapiens interleukin 28 alpha receptor (IL28RA) mRNA, complete cds.
KJ895735 - Synthetic construct Homo sapiens clone ccsbBroadEn_05129 IL28RA gene, encodes complete protein.
AB590083 - Synthetic construct DNA, clone: pFN21AF0190, Homo sapiens IL28RA gene for interleukin 28 receptor, alpha, without stop codon, in Flexi system.
BC101407 - Homo sapiens interleukin 28 receptor, alpha (interferon, lambda receptor), mRNA (cDNA clone IMAGE:40003775).
BC101975 - Homo sapiens interleukin 28 receptor, alpha (interferon, lambda receptor), mRNA (cDNA clone IMAGE:40003772), partial cds.
BC139722 - Homo sapiens interleukin 28 receptor, alpha (interferon, lambda receptor), mRNA (cDNA clone IMAGE:40003768), partial cds.
BC101408 - Homo sapiens interleukin 28 receptor, alpha (interferon, lambda receptor), mRNA (cDNA clone IMAGE:40003773), partial cds.
AY129153 - Homo sapiens interleukin 28 receptor A splice variant 3 (IL28RA) mRNA, complete cds; alternatively spliced.
JD143104 - Sequence 124128 from Patent EP1572962.
JD557084 - Sequence 538108 from Patent EP1572962.
JD501075 - Sequence 482099 from Patent EP1572962.
JD500777 - Sequence 481801 from Patent EP1572962.
JD088843 - Sequence 69867 from Patent EP1572962.
JD525433 - Sequence 506457 from Patent EP1572962.
JD052047 - Sequence 33071 from Patent EP1572962.
JD097350 - Sequence 78374 from Patent EP1572962.
JD097180 - Sequence 78204 from Patent EP1572962.
JD097134 - Sequence 78158 from Patent EP1572962.
JD334777 - Sequence 315801 from Patent EP1572962.
JD229379 - Sequence 210403 from Patent EP1572962.
JD509573 - Sequence 490597 from Patent EP1572962.
JD544147 - Sequence 525171 from Patent EP1572962.
JD547164 - Sequence 528188 from Patent EP1572962.
JD483526 - Sequence 464550 from Patent EP1572962.
JD429867 - Sequence 410891 from Patent EP1572962.
JD282781 - Sequence 263805 from Patent EP1572962.
JD543624 - Sequence 524648 from Patent EP1572962.
JD330154 - Sequence 311178 from Patent EP1572962.
JD527048 - Sequence 508072 from Patent EP1572962.
JD291024 - Sequence 272048 from Patent EP1572962.
JD351891 - Sequence 332915 from Patent EP1572962.
JD444977 - Sequence 426001 from Patent EP1572962.
JD296091 - Sequence 277115 from Patent EP1572962.
JD073164 - Sequence 54188 from Patent EP1572962.
JD555464 - Sequence 536488 from Patent EP1572962.
JD436112 - Sequence 417136 from Patent EP1572962.
JD468442 - Sequence 449466 from Patent EP1572962.
JD338325 - Sequence 319349 from Patent EP1572962.
JD170653 - Sequence 151677 from Patent EP1572962.
JD221260 - Sequence 202284 from Patent EP1572962.
JD288530 - Sequence 269554 from Patent EP1572962.
JD414369 - Sequence 395393 from Patent EP1572962.
JD068293 - Sequence 49317 from Patent EP1572962.
JD367941 - Sequence 348965 from Patent EP1572962.
JD498573 - Sequence 479597 from Patent EP1572962.
JD462639 - Sequence 443663 from Patent EP1572962.
JD511678 - Sequence 492702 from Patent EP1572962.
JD200493 - Sequence 181517 from Patent EP1572962.
JD065518 - Sequence 46542 from Patent EP1572962.
JD420852 - Sequence 401876 from Patent EP1572962.
JD532909 - Sequence 513933 from Patent EP1572962.
JD187196 - Sequence 168220 from Patent EP1572962.
JD309679 - Sequence 290703 from Patent EP1572962.
JD402051 - Sequence 383075 from Patent EP1572962.
JD252257 - Sequence 233281 from Patent EP1572962.
JD418368 - Sequence 399392 from Patent EP1572962.
JD048194 - Sequence 29218 from Patent EP1572962.
JD216332 - Sequence 197356 from Patent EP1572962.
JD358623 - Sequence 339647 from Patent EP1572962.
JD481319 - Sequence 462343 from Patent EP1572962.
JD555887 - Sequence 536911 from Patent EP1572962.
JD468092 - Sequence 449116 from Patent EP1572962.
JD323777 - Sequence 304801 from Patent EP1572962.
JD173279 - Sequence 154303 from Patent EP1572962.
JD203497 - Sequence 184521 from Patent EP1572962.
JD339221 - Sequence 320245 from Patent EP1572962.
JD065523 - Sequence 46547 from Patent EP1572962.
JD186368 - Sequence 167392 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8IU57 (Reactome details) participates in the following event(s):

R-HSA-8987120 JAK1 binds IFNLR1
R-HSA-448661 IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1
R-HSA-8987040 IFNL1:IFNLR1:p‑JAK1:IL10RB:p‑TYK2 phosphorylates IFNLR1
R-HSA-8854691 Interleukin-20 family signaling
R-HSA-449836 Other interleukin signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000327535.1, ENST00000327535.2, ENST00000327535.3, ENST00000327535.4, ENST00000327535.5, IL28RA, INLR1_HUMAN, LICR2, NM_170743, Q5VTX5, Q5VTX7, Q5VTX8, Q6ZML8, Q8IU57, Q8IV66, Q8IZI7, Q8IZI8, uc317sho.1, uc317sho.2
UCSC ID: ENST00000327535.6_7
RefSeq Accession: NM_170743.4
Protein: Q8IU57 (aka I28RA_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.