Human Gene IGF2R (ENST00000356956.6_5) from GENCODE V47lift37
Description: insulin like growth factor 2 receptor (from RefSeq NM_000876.4)
Gencode Transcript: ENST00000356956.6_5
Gencode Gene: ENSG00000197081.16_12
Transcript (Including UTRs)
Position: hg19 chr6:160,390,114-160,532,536 Size: 142,423 Total Exon Count: 48 Strand: +
Coding Region
Position: hg19 chr6:160,390,279-160,526,116 Size: 135,838 Coding Exon Count: 48
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: MPRI_HUMAN
DESCRIPTION: RecName: Full=Cation-independent mannose-6-phosphate receptor; Short=CI Man-6-P receptor; Short=CI-MPR; Short=M6PR; AltName: Full=300 kDa mannose 6-phosphate receptor; Short=MPR 300; AltName: Full=Insulin-like growth factor 2 receptor; AltName: Full=Insulin-like growth factor II receptor; Short=IGF-II receptor; AltName: Full=M6P/IGF2 receptor; Short=M6P/IGF2R; AltName: CD_antigen=CD222; Flags: Precursor;
FUNCTION: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.SUBUNIT: Binds HA-I and HA-II plasma membrane adapters (By similarity). Interacts with DPP4; the interaction is direct. Binds GGA1, GGA2 and GGA3.SUBCELLULAR LOCATION: Lysosome membrane; Single-pass type I membrane protein. Note=Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.DOMAIN: Contains 15 repeating units of approximately 147 AA harboring four disulfide bonds each. The most highly conserved region within the repeat consists of a stretch of 13 AA that contains cysteines at both ends.SIMILARITY: Belongs to the MRL1/IGF2R family.SIMILARITY: Contains 1 fibronectin type-II domain.WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/IGF2RID380.html";WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/igf2r/";
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR000479 - CIMR
IPR000562 - FN_type2_col-bd
IPR013806 - Kringle-like
IPR009011 - Man6P_isomerase_rcpt-bd_dom
Pfam Domains: PF00040 - Fibronectin type II domain
PF00878 - Cation-independent mannose-6-phosphate receptor repeat
PF02157 - Mannose-6-phosphate receptor
PF09451 - Autophagy-related protein 27
SCOP Domains: 50911 - Mannose 6-phosphate receptor domain
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
57440 - Kringle-like
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on P11717
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LF385160 - JP 2014500723-A/192663: Polycomb-Associated Non-Coding RNAs.Y00285 - Human mRNA for insuline-like growth factor II receptor.J03528 - Human cation-independent mannose 6-phosphate receptor mRNA, complete cds.BC172256 - Synthetic construct Homo sapiens clone IMAGE:100068950, MGC:198961 insulin-like growth factor 2 receptor (IGF2R) mRNA, encodes complete protein.AB209668 - Homo sapiens mRNA for Insulin-like growth factor 2 receptor variant protein.MA620737 - JP 2018138019-A/192663: Polycomb-Associated Non-Coding RNAs.LF212691 - JP 2014500723-A/20194: Polycomb-Associated Non-Coding RNAs.JD413224 - Sequence 394248 from Patent EP1572962.JD152482 - Sequence 133506 from Patent EP1572962.JD408601 - Sequence 389625 from Patent EP1572962.JD571854 - Sequence 1 from Patent WO2015030616.JD571855 - Sequence 2 from Patent WO2015030616.LF340226 - JP 2014500723-A/147729: Polycomb-Associated Non-Coding RNAs.LF340225 - JP 2014500723-A/147728: Polycomb-Associated Non-Coding RNAs.MA448268 - JP 2018138019-A/20194: Polycomb-Associated Non-Coding RNAs.MA575803 - JP 2018138019-A/147729: Polycomb-Associated Non-Coding RNAs.MA575802 - JP 2018138019-A/147728: Polycomb-Associated Non-Coding RNAs.LF340222 - JP 2014500723-A/147725: Polycomb-Associated Non-Coding RNAs.LF340218 - JP 2014500723-A/147721: Polycomb-Associated Non-Coding RNAs.LF340217 - JP 2014500723-A/147720: Polycomb-Associated Non-Coding RNAs.LF340216 - JP 2014500723-A/147719: Polycomb-Associated Non-Coding RNAs.LF340214 - JP 2014500723-A/147717: Polycomb-Associated Non-Coding RNAs.LF340213 - JP 2014500723-A/147716: Polycomb-Associated Non-Coding RNAs.LF340212 - JP 2014500723-A/147715: Polycomb-Associated Non-Coding RNAs.LF340211 - JP 2014500723-A/147714: Polycomb-Associated Non-Coding RNAs.LF340210 - JP 2014500723-A/147713: Polycomb-Associated Non-Coding RNAs.LF340209 - JP 2014500723-A/147712: Polycomb-Associated Non-Coding RNAs.LF340208 - JP 2014500723-A/147711: Polycomb-Associated Non-Coding RNAs.LF340207 - JP 2014500723-A/147710: Polycomb-Associated Non-Coding RNAs.LF340206 - JP 2014500723-A/147709: Polycomb-Associated Non-Coding RNAs.LF340205 - JP 2014500723-A/147708: Polycomb-Associated Non-Coding RNAs.LF340204 - JP 2014500723-A/147707: Polycomb-Associated Non-Coding RNAs.LF340203 - JP 2014500723-A/147706: Polycomb-Associated Non-Coding RNAs.LF340202 - JP 2014500723-A/147705: Polycomb-Associated Non-Coding RNAs.LF340201 - JP 2014500723-A/147704: Polycomb-Associated Non-Coding RNAs.LF340200 - JP 2014500723-A/147703: Polycomb-Associated Non-Coding RNAs.LF340198 - JP 2014500723-A/147701: Polycomb-Associated Non-Coding RNAs.LF340197 - JP 2014500723-A/147700: Polycomb-Associated Non-Coding RNAs.LF340196 - JP 2014500723-A/147699: Polycomb-Associated Non-Coding RNAs.LF340195 - JP 2014500723-A/147698: Polycomb-Associated Non-Coding RNAs.LF340194 - JP 2014500723-A/147697: Polycomb-Associated Non-Coding RNAs.LF340193 - JP 2014500723-A/147696: Polycomb-Associated Non-Coding RNAs.LF340192 - JP 2014500723-A/147695: Polycomb-Associated Non-Coding RNAs.S80783 - mannose 6-phosphate/insulin-like growth factor-II receptor [human, hepatocellular carcinomas, mRNA Partial Mutant, 72 nt].S80785 - mannose 6-phosphate/insulin-like growth factor-II receptor [human, hepatocellular carcinomas, mRNA Partial Mutant, 72 nt].LF340191 - JP 2014500723-A/147694: Polycomb-Associated Non-Coding RNAs.LF340190 - JP 2014500723-A/147693: Polycomb-Associated Non-Coding RNAs.LF340189 - JP 2014500723-A/147692: Polycomb-Associated Non-Coding RNAs.LF340188 - JP 2014500723-A/147691: Polycomb-Associated Non-Coding RNAs.LF340187 - JP 2014500723-A/147690: Polycomb-Associated Non-Coding RNAs.LF340186 - JP 2014500723-A/147689: Polycomb-Associated Non-Coding RNAs.LF340185 - JP 2014500723-A/147688: Polycomb-Associated Non-Coding RNAs.LF340184 - JP 2014500723-A/147687: Polycomb-Associated Non-Coding RNAs.AK300848 - Homo sapiens cDNA FLJ61170 complete cds, highly similar to Cation-independent mannose-6-phosphate receptor precursor.LF340183 - JP 2014500723-A/147686: Polycomb-Associated Non-Coding RNAs.LF340182 - JP 2014500723-A/147685: Polycomb-Associated Non-Coding RNAs.LF340181 - JP 2014500723-A/147684: Polycomb-Associated Non-Coding RNAs.S80797 - mannose 6-phosphate/insulin-like growth factor-II receptor {192-bp insert} [human, hepatocellular carcinomas, mRNA Partial Mutant, 225 nt].LF340180 - JP 2014500723-A/147683: Polycomb-Associated Non-Coding RNAs.LF340179 - JP 2014500723-A/147682: Polycomb-Associated Non-Coding RNAs.LF340177 - JP 2014500723-A/147680: Polycomb-Associated Non-Coding RNAs.LF340176 - JP 2014500723-A/147679: Polycomb-Associated Non-Coding RNAs.LF340175 - JP 2014500723-A/147678: Polycomb-Associated Non-Coding RNAs.LF340174 - JP 2014500723-A/147677: Polycomb-Associated Non-Coding RNAs.LF340173 - JP 2014500723-A/147676: Polycomb-Associated Non-Coding RNAs.LF340172 - JP 2014500723-A/147675: Polycomb-Associated Non-Coding RNAs.LF340171 - JP 2014500723-A/147674: Polycomb-Associated Non-Coding RNAs.JD462842 - Sequence 443866 from Patent EP1572962.JD446451 - Sequence 427475 from Patent EP1572962.JD113529 - Sequence 94553 from Patent EP1572962.JD546171 - Sequence 527195 from Patent EP1572962.LF340170 - JP 2014500723-A/147673: Polycomb-Associated Non-Coding RNAs.JD285058 - Sequence 266082 from Patent EP1572962.JD451138 - Sequence 432162 from Patent EP1572962.JD313986 - Sequence 295010 from Patent EP1572962.JD491512 - Sequence 472536 from Patent EP1572962.JD273918 - Sequence 254942 from Patent EP1572962.JD567129 - Sequence 548153 from Patent EP1572962.JD153850 - Sequence 134874 from Patent EP1572962.JD321384 - Sequence 302408 from Patent EP1572962.LF340169 - JP 2014500723-A/147672: Polycomb-Associated Non-Coding RNAs.JD377239 - Sequence 358263 from Patent EP1572962.JD505012 - Sequence 486036 from Patent EP1572962.JD462958 - Sequence 443982 from Patent EP1572962.JD111770 - Sequence 92794 from Patent EP1572962.JD472820 - Sequence 453844 from Patent EP1572962.LF340168 - JP 2014500723-A/147671: Polycomb-Associated Non-Coding RNAs.JD524241 - Sequence 505265 from Patent EP1572962.JD306623 - Sequence 287647 from Patent EP1572962.BC010121 - Homo sapiens cDNA clone IMAGE:3840062, partial cds.JD220922 - Sequence 201946 from Patent EP1572962.JD489171 - Sequence 470195 from Patent EP1572962.JD489172 - Sequence 470196 from Patent EP1572962.JD499748 - Sequence 480772 from Patent EP1572962.JD499749 - Sequence 480773 from Patent EP1572962.JD256641 - Sequence 237665 from Patent EP1572962.JD560776 - Sequence 541800 from Patent EP1572962.JD476982 - Sequence 458006 from Patent EP1572962.JD514141 - Sequence 495165 from Patent EP1572962.JD070317 - Sequence 51341 from Patent EP1572962.JD398175 - Sequence 379199 from Patent EP1572962.MA575799 - JP 2018138019-A/147725: Polycomb-Associated Non-Coding RNAs.MA575795 - JP 2018138019-A/147721: Polycomb-Associated Non-Coding RNAs.MA575794 - JP 2018138019-A/147720: Polycomb-Associated Non-Coding RNAs.MA575793 - JP 2018138019-A/147719: Polycomb-Associated Non-Coding RNAs.MA575791 - JP 2018138019-A/147717: Polycomb-Associated Non-Coding RNAs.MA575790 - JP 2018138019-A/147716: Polycomb-Associated Non-Coding RNAs.MA575789 - JP 2018138019-A/147715: Polycomb-Associated Non-Coding RNAs.MA575788 - JP 2018138019-A/147714: Polycomb-Associated Non-Coding RNAs.MA575787 - JP 2018138019-A/147713: Polycomb-Associated Non-Coding RNAs.MA575786 - JP 2018138019-A/147712: Polycomb-Associated Non-Coding RNAs.MA575785 - JP 2018138019-A/147711: Polycomb-Associated Non-Coding RNAs.MA575784 - JP 2018138019-A/147710: Polycomb-Associated Non-Coding RNAs.MA575783 - JP 2018138019-A/147709: Polycomb-Associated Non-Coding RNAs.MA575782 - JP 2018138019-A/147708: Polycomb-Associated Non-Coding RNAs.MA575781 - JP 2018138019-A/147707: Polycomb-Associated Non-Coding RNAs.MA575780 - JP 2018138019-A/147706: Polycomb-Associated Non-Coding RNAs.MA575779 - JP 2018138019-A/147705: Polycomb-Associated Non-Coding RNAs.MA575778 - JP 2018138019-A/147704: Polycomb-Associated Non-Coding RNAs.MA575777 - JP 2018138019-A/147703: Polycomb-Associated Non-Coding RNAs.MA575775 - JP 2018138019-A/147701: Polycomb-Associated Non-Coding RNAs.MA575774 - JP 2018138019-A/147700: Polycomb-Associated Non-Coding RNAs.MA575773 - JP 2018138019-A/147699: Polycomb-Associated Non-Coding RNAs.MA575772 - JP 2018138019-A/147698: Polycomb-Associated Non-Coding RNAs.MA575771 - JP 2018138019-A/147697: Polycomb-Associated Non-Coding RNAs.MA575770 - JP 2018138019-A/147696: Polycomb-Associated Non-Coding RNAs.MA575769 - JP 2018138019-A/147695: Polycomb-Associated Non-Coding RNAs.MA575768 - JP 2018138019-A/147694: Polycomb-Associated Non-Coding RNAs.MA575767 - JP 2018138019-A/147693: Polycomb-Associated Non-Coding RNAs.MA575766 - JP 2018138019-A/147692: Polycomb-Associated Non-Coding RNAs.MA575765 - JP 2018138019-A/147691: Polycomb-Associated Non-Coding RNAs.MA575764 - JP 2018138019-A/147690: Polycomb-Associated Non-Coding RNAs.MA575763 - JP 2018138019-A/147689: Polycomb-Associated Non-Coding RNAs.MA575762 - JP 2018138019-A/147688: Polycomb-Associated Non-Coding RNAs.MA575761 - JP 2018138019-A/147687: Polycomb-Associated Non-Coding RNAs.MA575760 - JP 2018138019-A/147686: Polycomb-Associated Non-Coding RNAs.MA575759 - JP 2018138019-A/147685: Polycomb-Associated Non-Coding RNAs.MA575758 - JP 2018138019-A/147684: Polycomb-Associated Non-Coding RNAs.MA575757 - JP 2018138019-A/147683: Polycomb-Associated Non-Coding RNAs.MA575756 - JP 2018138019-A/147682: Polycomb-Associated Non-Coding RNAs.MA575754 - JP 2018138019-A/147680: Polycomb-Associated Non-Coding RNAs.MA575753 - JP 2018138019-A/147679: Polycomb-Associated Non-Coding RNAs.MA575752 - JP 2018138019-A/147678: Polycomb-Associated Non-Coding RNAs.MA575751 - JP 2018138019-A/147677: Polycomb-Associated Non-Coding RNAs.MA575750 - JP 2018138019-A/147676: Polycomb-Associated Non-Coding RNAs.MA575749 - JP 2018138019-A/147675: Polycomb-Associated Non-Coding RNAs.MA575748 - JP 2018138019-A/147674: Polycomb-Associated Non-Coding RNAs.MA575747 - JP 2018138019-A/147673: Polycomb-Associated Non-Coding RNAs.MA575746 - JP 2018138019-A/147672: Polycomb-Associated Non-Coding RNAs.MA575745 - JP 2018138019-A/147671: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: ENST00000356956.1, ENST00000356956.2, ENST00000356956.3, ENST00000356956.4, ENST00000356956.5, MPRI, MPRI_HUMAN, NM_000876, P11717, Q7Z7G9, Q96PT5, uc317zus.1, uc317zus.2UCSC ID: ENST00000356956.6_5RefSeq Accession: NM_000876.4
Protein: P11717
(aka MPRI_HUMAN)
Gene Model Information
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for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.