Human Gene IGF2R (ENST00000356956.6_5) from GENCODE V47lift37
  Description: insulin like growth factor 2 receptor (from RefSeq NM_000876.4)
Gencode Transcript: ENST00000356956.6_5
Gencode Gene: ENSG00000197081.16_12
Transcript (Including UTRs)
   Position: hg19 chr6:160,390,114-160,532,536 Size: 142,423 Total Exon Count: 48 Strand: +
Coding Region
   Position: hg19 chr6:160,390,279-160,526,116 Size: 135,838 Coding Exon Count: 48 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:160,390,114-160,532,536)mRNA (may differ from genome)Protein (2491 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MPRI_HUMAN
DESCRIPTION: RecName: Full=Cation-independent mannose-6-phosphate receptor; Short=CI Man-6-P receptor; Short=CI-MPR; Short=M6PR; AltName: Full=300 kDa mannose 6-phosphate receptor; Short=MPR 300; AltName: Full=Insulin-like growth factor 2 receptor; AltName: Full=Insulin-like growth factor II receptor; Short=IGF-II receptor; AltName: Full=M6P/IGF2 receptor; Short=M6P/IGF2R; AltName: CD_antigen=CD222; Flags: Precursor;
FUNCTION: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.
SUBUNIT: Binds HA-I and HA-II plasma membrane adapters (By similarity). Interacts with DPP4; the interaction is direct. Binds GGA1, GGA2 and GGA3.
SUBCELLULAR LOCATION: Lysosome membrane; Single-pass type I membrane protein. Note=Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.
DOMAIN: Contains 15 repeating units of approximately 147 AA harboring four disulfide bonds each. The most highly conserved region within the repeat consists of a stretch of 13 AA that contains cysteines at both ends.
SIMILARITY: Belongs to the MRL1/IGF2R family.
SIMILARITY: Contains 1 fibronectin type-II domain.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/IGF2RID380.html";
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/igf2r/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: IGF2R
Diseases sorted by gene-association score: hepatocellular carcinoma* (418), mucolipidosis ii alpha/beta (10), inclusion-cell disease (7), glycogen storage disease ii (7), cerebral palsy, ataxic, autosomal recessive (5), chromosome 3q29 microdeletion syndrome (5), breast cancer (2), colorectal cancer (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 37.20 RPKM in Cells - Cultured fibroblasts
Total median expression: 645.17 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -70.60165-0.428 Picture PostScript Text
3' UTR -2029.406420-0.316 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000479 - CIMR
IPR000562 - FN_type2_col-bd
IPR013806 - Kringle-like
IPR009011 - Man6P_isomerase_rcpt-bd_dom

Pfam Domains:
PF00040 - Fibronectin type II domain
PF00878 - Cation-independent mannose-6-phosphate receptor repeat
PF02157 - Mannose-6-phosphate receptor
PF09451 - Autophagy-related protein 27

SCOP Domains:
50911 - Mannose 6-phosphate receptor domain
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
57440 - Kringle-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1E6F - X-ray MuPIT 1GP0 - X-ray MuPIT 1GP3 - X-ray MuPIT 1GQB - X-ray MuPIT 1JWG - X-ray MuPIT 1LF8 - X-ray MuPIT 2CNJ - NMR MuPIT 2L29 - NMR MuPIT 2L2A - NMR MuPIT 2V5N - X-ray MuPIT 2V5O - X-ray MuPIT 2V5P - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P11717
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details Gene Details Gene Details
Gene SorterGene Sorter Gene Sorter Gene Sorter
 RGDEnsembl  SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001965 G-protein alpha-subunit binding
GO:0001972 retinoic acid binding
GO:0004930 G-protein coupled receptor activity
GO:0005010 insulin-like growth factor-activated receptor activity
GO:0005515 protein binding
GO:0005520 insulin-like growth factor binding
GO:0005537 mannose binding
GO:0019899 enzyme binding
GO:0031995 insulin-like growth factor II binding
GO:0038023 signaling receptor activity
GO:0042802 identical protein binding
GO:0051219 phosphoprotein binding

Biological Process:
GO:0001889 liver development
GO:0006898 receptor-mediated endocytosis
GO:0007041 lysosomal transport
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007283 spermatogenesis
GO:0009791 post-embryonic development
GO:0031100 animal organ regeneration
GO:0032526 response to retinoic acid
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043312 neutrophil degranulation
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0061024 membrane organization

Cellular Component:
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005641 nuclear envelope lumen
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030118 clathrin coat
GO:0030133 transport vesicle
GO:0030139 endocytic vesicle
GO:0030140 trans-Golgi network transport vesicle
GO:0030665 clathrin-coated vesicle membrane
GO:0030667 secretory granule membrane
GO:0032588 trans-Golgi network membrane
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  LF385160 - JP 2014500723-A/192663: Polycomb-Associated Non-Coding RNAs.
Y00285 - Human mRNA for insuline-like growth factor II receptor.
J03528 - Human cation-independent mannose 6-phosphate receptor mRNA, complete cds.
BC172256 - Synthetic construct Homo sapiens clone IMAGE:100068950, MGC:198961 insulin-like growth factor 2 receptor (IGF2R) mRNA, encodes complete protein.
AB209668 - Homo sapiens mRNA for Insulin-like growth factor 2 receptor variant protein.
MA620737 - JP 2018138019-A/192663: Polycomb-Associated Non-Coding RNAs.
LF212691 - JP 2014500723-A/20194: Polycomb-Associated Non-Coding RNAs.
JD413224 - Sequence 394248 from Patent EP1572962.
JD152482 - Sequence 133506 from Patent EP1572962.
JD408601 - Sequence 389625 from Patent EP1572962.
JD571854 - Sequence 1 from Patent WO2015030616.
JD571855 - Sequence 2 from Patent WO2015030616.
LF340226 - JP 2014500723-A/147729: Polycomb-Associated Non-Coding RNAs.
LF340225 - JP 2014500723-A/147728: Polycomb-Associated Non-Coding RNAs.
MA448268 - JP 2018138019-A/20194: Polycomb-Associated Non-Coding RNAs.
MA575803 - JP 2018138019-A/147729: Polycomb-Associated Non-Coding RNAs.
MA575802 - JP 2018138019-A/147728: Polycomb-Associated Non-Coding RNAs.
LF340222 - JP 2014500723-A/147725: Polycomb-Associated Non-Coding RNAs.
LF340218 - JP 2014500723-A/147721: Polycomb-Associated Non-Coding RNAs.
LF340217 - JP 2014500723-A/147720: Polycomb-Associated Non-Coding RNAs.
LF340216 - JP 2014500723-A/147719: Polycomb-Associated Non-Coding RNAs.
LF340214 - JP 2014500723-A/147717: Polycomb-Associated Non-Coding RNAs.
LF340213 - JP 2014500723-A/147716: Polycomb-Associated Non-Coding RNAs.
LF340212 - JP 2014500723-A/147715: Polycomb-Associated Non-Coding RNAs.
LF340211 - JP 2014500723-A/147714: Polycomb-Associated Non-Coding RNAs.
LF340210 - JP 2014500723-A/147713: Polycomb-Associated Non-Coding RNAs.
LF340209 - JP 2014500723-A/147712: Polycomb-Associated Non-Coding RNAs.
LF340208 - JP 2014500723-A/147711: Polycomb-Associated Non-Coding RNAs.
LF340207 - JP 2014500723-A/147710: Polycomb-Associated Non-Coding RNAs.
LF340206 - JP 2014500723-A/147709: Polycomb-Associated Non-Coding RNAs.
LF340205 - JP 2014500723-A/147708: Polycomb-Associated Non-Coding RNAs.
LF340204 - JP 2014500723-A/147707: Polycomb-Associated Non-Coding RNAs.
LF340203 - JP 2014500723-A/147706: Polycomb-Associated Non-Coding RNAs.
LF340202 - JP 2014500723-A/147705: Polycomb-Associated Non-Coding RNAs.
LF340201 - JP 2014500723-A/147704: Polycomb-Associated Non-Coding RNAs.
LF340200 - JP 2014500723-A/147703: Polycomb-Associated Non-Coding RNAs.
LF340198 - JP 2014500723-A/147701: Polycomb-Associated Non-Coding RNAs.
LF340197 - JP 2014500723-A/147700: Polycomb-Associated Non-Coding RNAs.
LF340196 - JP 2014500723-A/147699: Polycomb-Associated Non-Coding RNAs.
LF340195 - JP 2014500723-A/147698: Polycomb-Associated Non-Coding RNAs.
LF340194 - JP 2014500723-A/147697: Polycomb-Associated Non-Coding RNAs.
LF340193 - JP 2014500723-A/147696: Polycomb-Associated Non-Coding RNAs.
LF340192 - JP 2014500723-A/147695: Polycomb-Associated Non-Coding RNAs.
S80783 - mannose 6-phosphate/insulin-like growth factor-II receptor [human, hepatocellular carcinomas, mRNA Partial Mutant, 72 nt].
S80785 - mannose 6-phosphate/insulin-like growth factor-II receptor [human, hepatocellular carcinomas, mRNA Partial Mutant, 72 nt].
LF340191 - JP 2014500723-A/147694: Polycomb-Associated Non-Coding RNAs.
LF340190 - JP 2014500723-A/147693: Polycomb-Associated Non-Coding RNAs.
LF340189 - JP 2014500723-A/147692: Polycomb-Associated Non-Coding RNAs.
LF340188 - JP 2014500723-A/147691: Polycomb-Associated Non-Coding RNAs.
LF340187 - JP 2014500723-A/147690: Polycomb-Associated Non-Coding RNAs.
LF340186 - JP 2014500723-A/147689: Polycomb-Associated Non-Coding RNAs.
LF340185 - JP 2014500723-A/147688: Polycomb-Associated Non-Coding RNAs.
LF340184 - JP 2014500723-A/147687: Polycomb-Associated Non-Coding RNAs.
AK300848 - Homo sapiens cDNA FLJ61170 complete cds, highly similar to Cation-independent mannose-6-phosphate receptor precursor.
LF340183 - JP 2014500723-A/147686: Polycomb-Associated Non-Coding RNAs.
LF340182 - JP 2014500723-A/147685: Polycomb-Associated Non-Coding RNAs.
LF340181 - JP 2014500723-A/147684: Polycomb-Associated Non-Coding RNAs.
S80797 - mannose 6-phosphate/insulin-like growth factor-II receptor {192-bp insert} [human, hepatocellular carcinomas, mRNA Partial Mutant, 225 nt].
LF340180 - JP 2014500723-A/147683: Polycomb-Associated Non-Coding RNAs.
LF340179 - JP 2014500723-A/147682: Polycomb-Associated Non-Coding RNAs.
LF340177 - JP 2014500723-A/147680: Polycomb-Associated Non-Coding RNAs.
LF340176 - JP 2014500723-A/147679: Polycomb-Associated Non-Coding RNAs.
LF340175 - JP 2014500723-A/147678: Polycomb-Associated Non-Coding RNAs.
LF340174 - JP 2014500723-A/147677: Polycomb-Associated Non-Coding RNAs.
LF340173 - JP 2014500723-A/147676: Polycomb-Associated Non-Coding RNAs.
LF340172 - JP 2014500723-A/147675: Polycomb-Associated Non-Coding RNAs.
LF340171 - JP 2014500723-A/147674: Polycomb-Associated Non-Coding RNAs.
JD462842 - Sequence 443866 from Patent EP1572962.
JD446451 - Sequence 427475 from Patent EP1572962.
JD113529 - Sequence 94553 from Patent EP1572962.
JD546171 - Sequence 527195 from Patent EP1572962.
LF340170 - JP 2014500723-A/147673: Polycomb-Associated Non-Coding RNAs.
JD285058 - Sequence 266082 from Patent EP1572962.
JD451138 - Sequence 432162 from Patent EP1572962.
JD313986 - Sequence 295010 from Patent EP1572962.
JD491512 - Sequence 472536 from Patent EP1572962.
JD273918 - Sequence 254942 from Patent EP1572962.
JD567129 - Sequence 548153 from Patent EP1572962.
JD153850 - Sequence 134874 from Patent EP1572962.
JD321384 - Sequence 302408 from Patent EP1572962.
LF340169 - JP 2014500723-A/147672: Polycomb-Associated Non-Coding RNAs.
JD377239 - Sequence 358263 from Patent EP1572962.
JD505012 - Sequence 486036 from Patent EP1572962.
JD462958 - Sequence 443982 from Patent EP1572962.
JD111770 - Sequence 92794 from Patent EP1572962.
JD472820 - Sequence 453844 from Patent EP1572962.
LF340168 - JP 2014500723-A/147671: Polycomb-Associated Non-Coding RNAs.
JD524241 - Sequence 505265 from Patent EP1572962.
JD306623 - Sequence 287647 from Patent EP1572962.
BC010121 - Homo sapiens cDNA clone IMAGE:3840062, partial cds.
JD220922 - Sequence 201946 from Patent EP1572962.
JD489171 - Sequence 470195 from Patent EP1572962.
JD489172 - Sequence 470196 from Patent EP1572962.
JD499748 - Sequence 480772 from Patent EP1572962.
JD499749 - Sequence 480773 from Patent EP1572962.
JD256641 - Sequence 237665 from Patent EP1572962.
JD560776 - Sequence 541800 from Patent EP1572962.
JD476982 - Sequence 458006 from Patent EP1572962.
JD514141 - Sequence 495165 from Patent EP1572962.
JD070317 - Sequence 51341 from Patent EP1572962.
JD398175 - Sequence 379199 from Patent EP1572962.
MA575799 - JP 2018138019-A/147725: Polycomb-Associated Non-Coding RNAs.
MA575795 - JP 2018138019-A/147721: Polycomb-Associated Non-Coding RNAs.
MA575794 - JP 2018138019-A/147720: Polycomb-Associated Non-Coding RNAs.
MA575793 - JP 2018138019-A/147719: Polycomb-Associated Non-Coding RNAs.
MA575791 - JP 2018138019-A/147717: Polycomb-Associated Non-Coding RNAs.
MA575790 - JP 2018138019-A/147716: Polycomb-Associated Non-Coding RNAs.
MA575789 - JP 2018138019-A/147715: Polycomb-Associated Non-Coding RNAs.
MA575788 - JP 2018138019-A/147714: Polycomb-Associated Non-Coding RNAs.
MA575787 - JP 2018138019-A/147713: Polycomb-Associated Non-Coding RNAs.
MA575786 - JP 2018138019-A/147712: Polycomb-Associated Non-Coding RNAs.
MA575785 - JP 2018138019-A/147711: Polycomb-Associated Non-Coding RNAs.
MA575784 - JP 2018138019-A/147710: Polycomb-Associated Non-Coding RNAs.
MA575783 - JP 2018138019-A/147709: Polycomb-Associated Non-Coding RNAs.
MA575782 - JP 2018138019-A/147708: Polycomb-Associated Non-Coding RNAs.
MA575781 - JP 2018138019-A/147707: Polycomb-Associated Non-Coding RNAs.
MA575780 - JP 2018138019-A/147706: Polycomb-Associated Non-Coding RNAs.
MA575779 - JP 2018138019-A/147705: Polycomb-Associated Non-Coding RNAs.
MA575778 - JP 2018138019-A/147704: Polycomb-Associated Non-Coding RNAs.
MA575777 - JP 2018138019-A/147703: Polycomb-Associated Non-Coding RNAs.
MA575775 - JP 2018138019-A/147701: Polycomb-Associated Non-Coding RNAs.
MA575774 - JP 2018138019-A/147700: Polycomb-Associated Non-Coding RNAs.
MA575773 - JP 2018138019-A/147699: Polycomb-Associated Non-Coding RNAs.
MA575772 - JP 2018138019-A/147698: Polycomb-Associated Non-Coding RNAs.
MA575771 - JP 2018138019-A/147697: Polycomb-Associated Non-Coding RNAs.
MA575770 - JP 2018138019-A/147696: Polycomb-Associated Non-Coding RNAs.
MA575769 - JP 2018138019-A/147695: Polycomb-Associated Non-Coding RNAs.
MA575768 - JP 2018138019-A/147694: Polycomb-Associated Non-Coding RNAs.
MA575767 - JP 2018138019-A/147693: Polycomb-Associated Non-Coding RNAs.
MA575766 - JP 2018138019-A/147692: Polycomb-Associated Non-Coding RNAs.
MA575765 - JP 2018138019-A/147691: Polycomb-Associated Non-Coding RNAs.
MA575764 - JP 2018138019-A/147690: Polycomb-Associated Non-Coding RNAs.
MA575763 - JP 2018138019-A/147689: Polycomb-Associated Non-Coding RNAs.
MA575762 - JP 2018138019-A/147688: Polycomb-Associated Non-Coding RNAs.
MA575761 - JP 2018138019-A/147687: Polycomb-Associated Non-Coding RNAs.
MA575760 - JP 2018138019-A/147686: Polycomb-Associated Non-Coding RNAs.
MA575759 - JP 2018138019-A/147685: Polycomb-Associated Non-Coding RNAs.
MA575758 - JP 2018138019-A/147684: Polycomb-Associated Non-Coding RNAs.
MA575757 - JP 2018138019-A/147683: Polycomb-Associated Non-Coding RNAs.
MA575756 - JP 2018138019-A/147682: Polycomb-Associated Non-Coding RNAs.
MA575754 - JP 2018138019-A/147680: Polycomb-Associated Non-Coding RNAs.
MA575753 - JP 2018138019-A/147679: Polycomb-Associated Non-Coding RNAs.
MA575752 - JP 2018138019-A/147678: Polycomb-Associated Non-Coding RNAs.
MA575751 - JP 2018138019-A/147677: Polycomb-Associated Non-Coding RNAs.
MA575750 - JP 2018138019-A/147676: Polycomb-Associated Non-Coding RNAs.
MA575749 - JP 2018138019-A/147675: Polycomb-Associated Non-Coding RNAs.
MA575748 - JP 2018138019-A/147674: Polycomb-Associated Non-Coding RNAs.
MA575747 - JP 2018138019-A/147673: Polycomb-Associated Non-Coding RNAs.
MA575746 - JP 2018138019-A/147672: Polycomb-Associated Non-Coding RNAs.
MA575745 - JP 2018138019-A/147671: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P11717 (Reactome details) participates in the following event(s):

R-HSA-421836 trans-Golgi Network Derived Vesicle Uncoating
R-HSA-421833 Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture
R-HSA-6798743 Exocytosis of secretory granule membrane proteins
R-HSA-421835 trans-Golgi Network Vesicle Scission
R-HSA-421831 trans-Golgi Network Coat Assembly
R-HSA-8866277 AP-2 directly binds some endocytic cargo
R-HSA-6814674 Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins
R-HSA-6814670 ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation
R-HSA-6814675 RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN
R-HSA-8867756 CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
R-HSA-8868071 Clathrin recruits PIK3C2A
R-HSA-8868661 Dynamin-mediated GTP hydrolysis promotes vesicle scission
R-HSA-8868648 SYNJ hydrolyze PI(4,5)P2 to PI(4)P
R-HSA-8871194 RAB5 and GAPVD1 bind AP-2
R-HSA-8868658 HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
R-HSA-8868659 Clathrin recruits auxilins to the clathrin-coated vesicle
R-HSA-8868660 Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
R-HSA-8867754 F- and N- BAR domain proteins bind the clathrin-coated pit
R-HSA-8868230 SNX9 recruits components of the actin polymerizing machinery
R-HSA-8868072 Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
R-HSA-8868236 BAR domain proteins recruit dynamin
R-HSA-8868651 Endophilins recruit synaptojanins to the clathrin-coated pit
R-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-6798695 Neutrophil degranulation
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
R-HSA-421837 Clathrin derived vesicle budding
R-HSA-168249 Innate Immune System
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-199992 trans-Golgi Network Vesicle Budding
R-HSA-168256 Immune System
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-199991 Membrane Trafficking
R-HSA-5653656 Vesicle-mediated transport

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000356956.1, ENST00000356956.2, ENST00000356956.3, ENST00000356956.4, ENST00000356956.5, MPRI, MPRI_HUMAN, NM_000876, P11717, Q7Z7G9, Q96PT5, uc317zus.1, uc317zus.2
UCSC ID: ENST00000356956.6_5
RefSeq Accession: NM_000876.4
Protein: P11717 (aka MPRI_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.