Human Gene IGFBP1 (ENST00000275525.8_8) from GENCODE V47lift37
  Description: insulin like growth factor binding protein 1 (from RefSeq NM_000596.4)
Gencode Transcript: ENST00000275525.8_8
Gencode Gene: ENSG00000146678.10_11
Transcript (Including UTRs)
   Position: hg19 chr7:45,928,087-45,933,259 Size: 5,173 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr7:45,928,252-45,932,690 Size: 4,439 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:45,928,087-45,933,259)mRNA (may differ from genome)Protein (259 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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-  Comments and Description Text from UniProtKB
  ID: IBP1_HUMAN
DESCRIPTION: RecName: Full=Insulin-like growth factor-binding protein 1; Short=IBP-1; Short=IGF-binding protein 1; Short=IGFBP-1; AltName: Full=Placental protein 12; Short=PP12; Flags: Precursor;
FUNCTION: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
SUBUNIT: Binds equally well IGF1 and IGF2.
SUBCELLULAR LOCATION: Secreted.
PTM: Phosphorylated; probably by casein kinase II. Phosphorylation alters the affinity of the protein for IGFs. In amniotic fluid, the unmodified protein is the most abundant form, while mono-, bi-, tri- and tetraphosphorylated forms are present in decreasing amounts. The phosphorylation state may influence the propensity to proteolysis.
SIMILARITY: Contains 1 IGFBP N-terminal domain.
SIMILARITY: Contains 1 thyroglobulin type-1 domain.
SEQUENCE CAUTION: Sequence=AAA52540.1; Type=Frameshift; Positions=55, 71;
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/igfbp1/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: IGFBP1
Diseases sorted by gene-association score: ovarian disease (16), insulin-like growth factor i (14), mild pre-eclampsia (14), pancreatic cancer, childhood (12), hyperinsulinism (11), polycystic ovary syndrome (11), hyperandrogenism (11), renal osteodystrophy (8), vascular disease (7), acromegaly (7), silver-russell syndrome (7), glucose intolerance (7), hyperproinsulinemia (7), turner syndrome (6), non-gestational choriocarcinoma (6), persistent fetal circulation syndrome (6), diabetes mellitus, insulin-dependent, 7 (5), diabetes mellitus, insulin-dependent (5), endometrial cancer (3), diabetes mellitus, noninsulin-dependent (2), obesity (2), eye disease (1), preeclampsia/eclampsia 1 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 198.93 RPKM in Liver
Total median expression: 208.28 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -47.00165-0.285 Picture PostScript Text
3' UTR -111.90569-0.197 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009030 - Growth_fac_rcpt
IPR000867 - IGFBP-like
IPR022322 - IGFBP1
IPR009168 - IGFBP1-6
IPR022321 - IGFBP_1-6_chordata
IPR017891 - Insulin_GF-bd_Cys-rich_CS
IPR000716 - Thyroglobulin_1

Pfam Domains:
PF00086 - Thyroglobulin type-1 repeat
PF00219 - Insulin-like growth factor binding protein

SCOP Domains:
57610 - Thyroglobulin type-1 domain
57184 - Growth factor receptor domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1ZT3 - X-ray 1ZT5 - X-ray 2DSQ - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P08833
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0005520 insulin-like growth factor binding
GO:0019838 growth factor binding
GO:0031994 insulin-like growth factor I binding
GO:0031995 insulin-like growth factor II binding

Biological Process:
GO:0001558 regulation of cell growth
GO:0007165 signal transduction
GO:0007568 aging
GO:0008286 insulin receptor signaling pathway
GO:0030307 positive regulation of cell growth
GO:0036499 PERK-mediated unfolded protein response
GO:0042246 tissue regeneration
GO:0043567 regulation of insulin-like growth factor receptor signaling pathway
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0090090 negative regulation of canonical Wnt signaling pathway

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005794 Golgi apparatus


-  Descriptions from all associated GenBank mRNAs
  AK314925 - Homo sapiens cDNA, FLJ95834, Homo sapiens insulin-like growth factor binding protein 1 (IGFBP1),mRNA.
BC057806 - Homo sapiens insulin-like growth factor binding protein 1, mRNA (cDNA clone MGC:71720 IMAGE:30337849), complete cds.
M31145 - Human insulin-like growth factor binding protein mRNA, complete cds.
BC035263 - Homo sapiens insulin-like growth factor binding protein 1, mRNA (cDNA clone MGC:30041 IMAGE:4800940), complete cds.
X12385 - Human mRNA for placental protein (PP12).
JD271300 - Sequence 252324 from Patent EP1572962.
M20841 - Human insulin-like growth factor (IGF) binding protein mRNA, complete cds.
X13405 - Human mRNA for insulin-like growth factor-binding protein/placental protein 12.
JD189475 - Sequence 170499 from Patent EP1572962.
JD405084 - Sequence 386108 from Patent EP1572962.
Y00856 - Human mRNA for insulin-like growth factor binding protein IBP-1 (IGF-binding protein).
BT019685 - Homo sapiens insulin-like growth factor binding protein 1 mRNA, complete cds.
KJ897038 - Synthetic construct Homo sapiens clone ccsbBroadEn_06432 IGFBP1 gene, encodes complete protein.
FJ795026 - Homo sapiens insulin-like growth factor binding protein 1 precursor (IGFBP1) mRNA, partial cds.
X15002 - Human mRNA for small insulin-like growth-factor-binding protein.
JD019436 - Sequence 460 from Patent EP1572962.
JD031934 - Sequence 12958 from Patent EP1572962.
JD082655 - Sequence 63679 from Patent EP1572962.
JD378778 - Sequence 359802 from Patent EP1572962.
JD538931 - Sequence 519955 from Patent EP1572962.
AF042356 - Homo sapiens insulin-like growth factor binding protein (IGFBP1) mRNA, 3' untranslated region, partial sequence.
JD337179 - Sequence 318203 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_ghrelinPathway - Ghrelin: Regulation of Food Intake and Energy Homeostasis

Reactome (by CSHL, EBI, and GO)

Protein P08833 (Reactome details) participates in the following event(s):

R-HSA-381487 IGFBP1 binds IGF forming IGF:IGFBP1
R-HSA-8952289 FAM20C phosphorylates FAM20C substrates
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-380994 ATF4 activates genes
R-HSA-392499 Metabolism of proteins
R-HSA-381042 PERK regulates gene expression
R-HSA-381119 Unfolded Protein Response (UPR)
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-597592 Post-translational protein modification

-  Other Names for This Gene
  Alternate Gene Symbols: A4D2F4, D3DVL9, ENST00000275525.1, ENST00000275525.2, ENST00000275525.3, ENST00000275525.4, ENST00000275525.5, ENST00000275525.6, ENST00000275525.7, IBP1, IBP1_HUMAN, NM_000596, P08833, Q8IYP5, uc317jie.1, uc317jie.2
UCSC ID: ENST00000275525.8_8
RefSeq Accession: NM_000596.4
Protein: P08833 (aka IBP1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.