ID:IBP7_HUMAN DESCRIPTION: RecName: Full=Insulin-like growth factor-binding protein 7; Short=IBP-7; Short=IGF-binding protein 7; Short=IGFBP-7; AltName: Full=IGFBP-rP1; AltName: Full=MAC25 protein; AltName: Full=PGI2-stimulating factor; AltName: Full=Prostacyclin-stimulating factor; AltName: Full=Tumor-derived adhesion factor; Short=TAF; Flags: Precursor; FUNCTION: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. SUBUNIT: May interact with VPS24/CHMP3; the relevance of such interaction however remains unclear. SUBCELLULAR LOCATION: Secreted. PTM: N-glycosylated. RNA EDITING: Modified_positions=78, 95; Note=Partially edited. In the brain, position 78 is edited at about 55% and position 95 at about 31%. DISEASE: Defects in IGFBP7 are the cause of retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS) [MIM:614224]. RAMSVPS is an autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction. SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. SIMILARITY: Contains 1 IGFBP N-terminal domain. SIMILARITY: Contains 1 Kazal-like domain. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/igfbp7/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q16270
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001558 regulation of cell growth GO:0007155 cell adhesion GO:0007566 embryo implantation GO:0008285 negative regulation of cell proliferation GO:0009408 response to heat GO:0014070 response to organic cyclic compound GO:0032526 response to retinoic acid GO:0032870 cellular response to hormone stimulus GO:0043687 post-translational protein modification GO:0044267 cellular protein metabolic process GO:0050810 regulation of steroid biosynthetic process GO:0051414 response to cortisol
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
