ID:IGSF5_HUMAN DESCRIPTION: RecName: Full=Immunoglobulin superfamily member 5; Short=IgSF5; AltName: Full=Junctional adhesion molecule 4; Short=JAM-4; FUNCTION: Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia- spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells- Sertoli cells (By similarity). SUBUNIT: Interacts with MAGI1 at tight junctions, forms a tripartite complex with NPHS1 (By similarity). Interacts with LNX1 isoform 2 via its PDZ 2 domain, it may also interact with other isoforms containing this domain (By similarity). SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein (By similarity). Cell junction, tight junction (By similarity). MISCELLANEOUS: A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells (PubMed:22042635). SIMILARITY: Belongs to the immunoglobulin superfamily. SIMILARITY: Contains 2 Ig-like V-type (immunoglobulin-like) domains. SEQUENCE CAUTION: Sequence=CAB90447.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NSI5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
