Human Gene IL10RB (ENST00000290200.7_5) from GENCODE V47lift37
Description: Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. (from UniProt Q08334) Gencode Transcript: ENST00000290200.7_5 Gencode Gene: ENSG00000243646.11_14 Transcript (Including UTRs) Position: hg19 chr21:34,638,672-34,669,526 Size: 30,855 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chr21:34,638,771-34,668,662 Size: 29,892 Coding Exon Count: 7
ID:I10R2_HUMAN DESCRIPTION: RecName: Full=Interleukin-10 receptor subunit beta; Short=IL-10 receptor subunit beta; Short=IL-10R subunit beta; Short=IL-10RB; AltName: Full=Cytokine receptor class-II member 4; AltName: Full=Cytokine receptor family 2 member 4; Short=CRF2-4; AltName: Full=Interleukin-10 receptor subunit 2; Short=IL-10R subunit 2; Short=IL-10R2; AltName: CD_antigen=CDw210b; Flags: Precursor; FUNCTION: Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IL29. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. POLYMORPHISM: Genetic variations in IL10RB influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424]. DISEASE: Defects in IL10RB are the cause of inflammatory bowel disease type 25 (IBD25) [MIM:612567]. It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. SIMILARITY: Belongs to the type II cytokine receptor family. SIMILARITY: Contains 2 fibronectin type-III domains. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il10rb/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q08334
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
