Human Gene IL11 (ENST00000264563.7_7) from GENCODE V47lift37
  Description: interleukin 11, transcript variant 1 (from RefSeq NM_000641.4)
Gencode Transcript: ENST00000264563.7_7
Gencode Gene: ENSG00000095752.7_11
Transcript (Including UTRs)
   Position: hg19 chr19:55,875,750-55,881,831 Size: 6,082 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr19:55,877,375-55,881,678 Size: 4,304 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:55,875,750-55,881,831)mRNA (may differ from genome)Protein (199 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: IL11_HUMAN
DESCRIPTION: RecName: Full=Interleukin-11; Short=IL-11; AltName: Full=Adipogenesis inhibitory factor; Short=AGIF; AltName: INN=Oprelvekin; Flags: Precursor;
FUNCTION: Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.
SUBCELLULAR LOCATION: Secreted.
PHARMACEUTICAL: Available under the name Neumega (Wyeth). Used for the prevention of severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy.
SIMILARITY: Belongs to the IL-6 superfamily.
WEB RESOURCE: Name=Neumega; Note=Clinical information on Neumega; URL="http://www.drugs.com/cdi/neumega.html";
WEB RESOURCE: Name=Wikipedia; Note=Interleukin-11 entry; URL="http://en.wikipedia.org/wiki/Interleukin_11";
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il11/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: IL11
Diseases sorted by gene-association score: hemorrhagic cystitis (25), mucositis (22), plasmacytoma (14), thrombocytopenia (13), papillary conjunctivitis (12), cyclic thrombocytopenia (12), thrombocytosis (12), acquired thrombocytopenia (11), giant papillary conjunctivitis (11), periostitis (11), megakaryocytic leukemia (9), inflammatory bowel disease 9 (9), epilepsy, familial temporal lobe, 2 (8), osteitis fibrosa (7), idiopathic edema (6), thrombocytopenic purpura, autoimmune (6), dengue disease (5), joint disorders (5), inflammatory bowel disease 3 (4), rheumatoid arthritis (4), aplastic anemia (3), essential thrombocythemia (3), osteoporosis (3), deficiency anemia (2), asthma (2), myelodysplastic syndrome (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D002945 Cisplatin
  • D007213 Indomethacin
  • D013749 Tetrachlorodibenzodioxin
  • C017947 sodium arsenite
  • C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)
  • C093973 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
  • C012796 2-butenal
  • C009505 4,4'-diaminodiphenylmethane
  • C459179 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.49 RPKM in Brain - Cerebellum
Total median expression: 18.73 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -78.30153-0.512 Picture PostScript Text
3' UTR -657.701625-0.405 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009079 - 4_helix_cytokine-like_core
IPR012351 - 4_helix_cytokine_core
IPR020438 - Interleukin-11
IPR020412 - Interleukin-11_mammalian

Pfam Domains:
PF07400 - Interleukin 11

SCOP Domains:
47266 - 4-helical cytokines

ModBase Predicted Comparative 3D Structure on P20809
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005125 cytokine activity
GO:0005142 interleukin-11 receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity

Biological Process:
GO:0008284 positive regulation of cell proliferation
GO:0010469 regulation of receptor activity
GO:0019221 cytokine-mediated signaling pathway
GO:0030183 B cell differentiation
GO:0030219 megakaryocyte differentiation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0043410 positive regulation of MAPK cascade
GO:0045444 fat cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046888 negative regulation of hormone secretion
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:1903659 regulation of complement-dependent cytotoxicity
GO:2000352 negative regulation of endothelial cell apoptotic process

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  X58377 - Human mRNa for adipogenesis inhibitory factor.
JD377245 - Sequence 358269 from Patent EP1572962.
JD423069 - Sequence 404093 from Patent EP1572962.
JD170871 - Sequence 151895 from Patent EP1572962.
JD530577 - Sequence 511601 from Patent EP1572962.
JD182704 - Sequence 163728 from Patent EP1572962.
JD101845 - Sequence 82869 from Patent EP1572962.
JD216120 - Sequence 197144 from Patent EP1572962.
JD247025 - Sequence 228049 from Patent EP1572962.
JD413452 - Sequence 394476 from Patent EP1572962.
JD247026 - Sequence 228050 from Patent EP1572962.
JD413453 - Sequence 394477 from Patent EP1572962.
JD198146 - Sequence 179170 from Patent EP1572962.
JD212752 - Sequence 193776 from Patent EP1572962.
JD086497 - Sequence 67521 from Patent EP1572962.
JD268982 - Sequence 250006 from Patent EP1572962.
JD078144 - Sequence 59168 from Patent EP1572962.
JD078836 - Sequence 59860 from Patent EP1572962.
JD242357 - Sequence 223381 from Patent EP1572962.
JD506270 - Sequence 487294 from Patent EP1572962.
JD356569 - Sequence 337593 from Patent EP1572962.
JD480597 - Sequence 461621 from Patent EP1572962.
JD342497 - Sequence 323521 from Patent EP1572962.
JD480596 - Sequence 461620 from Patent EP1572962.
JD342496 - Sequence 323520 from Patent EP1572962.
JD270145 - Sequence 251169 from Patent EP1572962.
JD365193 - Sequence 346217 from Patent EP1572962.
JD397914 - Sequence 378938 from Patent EP1572962.
JD070272 - Sequence 51296 from Patent EP1572962.
JD416336 - Sequence 397360 from Patent EP1572962.
JD096531 - Sequence 77555 from Patent EP1572962.
JD293753 - Sequence 274777 from Patent EP1572962.
JD153690 - Sequence 134714 from Patent EP1572962.
JD198633 - Sequence 179657 from Patent EP1572962.
JD179189 - Sequence 160213 from Patent EP1572962.
JD488280 - Sequence 469304 from Patent EP1572962.
JD227882 - Sequence 208906 from Patent EP1572962.
JD487907 - Sequence 468931 from Patent EP1572962.
JD113278 - Sequence 94302 from Patent EP1572962.
JD544197 - Sequence 525221 from Patent EP1572962.
JD091199 - Sequence 72223 from Patent EP1572962.
BC012506 - Homo sapiens interleukin 11, mRNA (cDNA clone MGC:21360 IMAGE:4476678), complete cds.
M57765 - Human interleukin 11 mRNA, complete cds.
E04896 - cDNA encoding a protein inhibiting adipocyte formation.
E08229 - DNA encoding adipogenesis inhibitory factor.
JD434471 - Sequence 415495 from Patent EP1572962.
JD303044 - Sequence 284068 from Patent EP1572962.
JD223166 - Sequence 204190 from Patent EP1572962.
JD297297 - Sequence 278321 from Patent EP1572962.
LF207488 - JP 2014500723-A/14991: Polycomb-Associated Non-Coding RNAs.
LF366646 - JP 2014500723-A/174149: Polycomb-Associated Non-Coding RNAs.
AK298973 - Homo sapiens cDNA FLJ52023 complete cds, highly similar to Interleukin-11 precursor.
JD426509 - Sequence 407533 from Patent EP1572962.
JD339750 - Sequence 320774 from Patent EP1572962.
JD297120 - Sequence 278144 from Patent EP1572962.
JD093752 - Sequence 74776 from Patent EP1572962.
AK290572 - Homo sapiens cDNA FLJ78117 complete cds, highly similar to Homo sapiens interleukin 11 (IL11), mRNA.
AK315294 - Homo sapiens cDNA, FLJ96313, Homo sapiens interleukin 11 (IL11), mRNA.
KJ891464 - Synthetic construct Homo sapiens clone ccsbBroadEn_00858 IL11 gene, encodes complete protein.
E08230 - DNA encoding adipogenesis inhibitory factor derivative.
AB590887 - Synthetic construct DNA, clone: pFN21AE1689, Homo sapiens IL11 gene for interleukin 11, without stop codon, in Flexi system.
LF212081 - JP 2014500723-A/19584: Polycomb-Associated Non-Coding RNAs.
LF366647 - JP 2014500723-A/174150: Polycomb-Associated Non-Coding RNAs.
MA602223 - JP 2018138019-A/174149: Polycomb-Associated Non-Coding RNAs.
MA602224 - JP 2018138019-A/174150: Polycomb-Associated Non-Coding RNAs.
MA443065 - JP 2018138019-A/14991: Polycomb-Associated Non-Coding RNAs.
MA447658 - JP 2018138019-A/19584: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_stemPathway - Regulation of hematopoiesis by cytokines
h_inflamPathway - Cytokines and Inflammatory Response
h_erythPathway - Erythrocyte Differentiation Pathway

Reactome (by CSHL, EBI, and GO)

Protein P20809 (Reactome details) participates in the following event(s):

R-HSA-449829 IL11 binds IL11RA
R-HSA-449976 IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)
R-HSA-6788467 IL-6-type cytokine receptor ligand interactions
R-HSA-6783589 Interleukin-6 family signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: B4DQV5, ENST00000264563.1, ENST00000264563.2, ENST00000264563.3, ENST00000264563.4, ENST00000264563.5, ENST00000264563.6, IL11 , IL11_HUMAN, NM_000641, P20809, Q96EB4, uc317hti.1, uc317hti.2
UCSC ID: ENST00000264563.7_7
RefSeq Accession: NM_000641.4
Protein: P20809 (aka IL11_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.