ID:IL13_HUMAN DESCRIPTION: RecName: Full=Interleukin-13; Short=IL-13; Flags: Precursor; FUNCTION: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. SUBUNIT: Interacts with IL13RA2. INTERACTION: P78552:IL13RA1; NbExp=4; IntAct=EBI-1647828, EBI-1391535; SUBCELLULAR LOCATION: Secreted. DISEASE: Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. SIMILARITY: Belongs to the IL-4/IL-13 family. CAUTION: It is uncertain whether Met-1 or Met-15 is the initiator. SEQUENCE CAUTION: Sequence=AAA36107.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAA83738.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAB01681.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAC03535.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAK53823.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA48824.1; Type=Erroneous initiation; Note=Translation N-terminally extended; WEB RESOURCE: Name=Wikipedia; Note=Interleukin-13 entry; URL="http://en.wikipedia.org/wiki/Interleukin_13"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il13/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P35225
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001774 microglial cell activation GO:0002639 positive regulation of immunoglobulin production GO:0006954 inflammatory response GO:0006955 immune response GO:0009612 response to mechanical stimulus GO:0010155 regulation of proton transport GO:0010469 regulation of receptor activity GO:0019221 cytokine-mediated signaling pathway GO:0030890 positive regulation of B cell proliferation GO:0032496 response to lipopolysaccharide GO:0032723 positive regulation of connective tissue growth factor production GO:0033861 negative regulation of NAD(P)H oxidase activity GO:0035094 response to nicotine GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0043032 positive regulation of macrophage activation GO:0043270 positive regulation of ion transport GO:0043306 positive regulation of mast cell degranulation GO:0045471 response to ethanol GO:0048661 positive regulation of smooth muscle cell proliferation GO:0050714 positive regulation of protein secretion GO:0051281 positive regulation of release of sequestered calcium ion into cytosol GO:0071260 cellular response to mechanical stimulus GO:0071345 cellular response to cytokine stimulus GO:0071635 negative regulation of transforming growth factor beta production GO:1901215 negative regulation of neuron death GO:1901247 negative regulation of lung ciliated cell differentiation GO:1901251 positive regulation of lung goblet cell differentiation GO:1903660 negative regulation of complement-dependent cytotoxicity GO:2000231 positive regulation of pancreatic stellate cell proliferation GO:2000352 negative regulation of endothelial cell apoptotic process
BC096141 - Homo sapiens interleukin 13, mRNA (cDNA clone MGC:116789 IMAGE:40002686), complete cds. BC096139 - Homo sapiens interleukin 13, mRNA (cDNA clone MGC:116787 IMAGE:40002680), complete cds. BC096138 - Homo sapiens interleukin 13, mRNA (cDNA clone MGC:116786 IMAGE:40002676), complete cds. BC096140 - Homo sapiens interleukin 13, mRNA (cDNA clone MGC:116788 IMAGE:40002684), complete cds. X69079 - H.sapiens interleukin-13 mRNA. AB463799 - Synthetic construct DNA, clone: pF1KB6756, Homo sapiens IL13 gene for interleukin 13, without stop codon, in Flexi system. KJ891466 - Synthetic construct Homo sapiens clone ccsbBroadEn_00860 IL13 gene, encodes complete protein. L06801 - Homo sapiens interleukin 13 mRNA, complete cds. AF043334 - Homo sapiens interleukin 13 precursor (IL13) mRNA, complete cds. FU768464 - Short interference ribonucleic acids for treating allergic diseases. KJ901525 - Synthetic construct Homo sapiens clone ccsbBroadEn_10919 IL13 gene, encodes complete protein. FU768463 - Short interference ribonucleic acids for treating allergic diseases. JD460866 - Sequence 441890 from Patent EP1572962. JD535233 - Sequence 516257 from Patent EP1572962. JD303117 - Sequence 284141 from Patent EP1572962. JD137333 - Sequence 118357 from Patent EP1572962. JD162535 - Sequence 143559 from Patent EP1572962. JD231205 - Sequence 212229 from Patent EP1572962. JD143645 - Sequence 124669 from Patent EP1572962. JD127599 - Sequence 108623 from Patent EP1572962. JD391363 - Sequence 372387 from Patent EP1572962. JD518587 - Sequence 499611 from Patent EP1572962. JD257338 - Sequence 238362 from Patent EP1572962. JD368427 - Sequence 349451 from Patent EP1572962. JD468468 - Sequence 449492 from Patent EP1572962. JD185817 - Sequence 166841 from Patent EP1572962. JD249141 - Sequence 230165 from Patent EP1572962. JD487162 - Sequence 468186 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_inflamPathway - Cytokines and Inflammatory Response h_dcPathway - Dendritic cells in regulating TH1 and TH2 Development h_cytokinePathway - Cytokine Network h_GATA3pathway - GATA3 participate in activating the Th2 cytokine genes expression
Reactome (by CSHL, EBI, and GO)
Protein P35225 (Reactome details) participates in the following event(s):
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
