ID:I13R1_HUMAN DESCRIPTION: RecName: Full=Interleukin-13 receptor subunit alpha-1; Short=IL-13 receptor subunit alpha-1; Short=IL-13R subunit alpha-1; Short=IL-13R-alpha-1; Short=IL-13RA1; AltName: Full=Cancer/testis antigen 19; Short=CT19; AltName: CD_antigen=CD213a1; Flags: Precursor; FUNCTION: Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity. SUBUNIT: Interleukin-13 receptor is a complex of IL4R, IL13RA1, and possibly other components. Interacts with TRAF3IP1. INTERACTION: P35225:IL13; NbExp=4; IntAct=EBI-1391535, EBI-1647828; P05112:IL4; NbExp=3; IntAct=EBI-1391535, EBI-367025; Q8TDR0:TRAF3IP1; NbExp=3; IntAct=EBI-1391535, EBI-928811; SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells. DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding. DOMAIN: The box 1 motif is required for JAK interaction and/or activation. SIMILARITY: Belongs to the type I cytokine receptor family. Type 5 subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P78552
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
