ID:IL15_HUMAN DESCRIPTION: RecName: Full=Interleukin-15; Short=IL-15; Flags: Precursor; FUNCTION: Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha. INTERACTION: Q13261:IL15RA; NbExp=3; IntAct=EBI-980274, EBI-980354; SUBCELLULAR LOCATION: Isoform IL15-S48AA: Secreted. SUBCELLULAR LOCATION: Isoform IL15-S21AA: Cytoplasm. Nucleus. Note=IL15-S21AA is not secreted, but rather is stored intracellularly, appearing in the nucleus and cytoplasmic components. TISSUE SPECIFICITY: Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15- S21AA is preferentially expressed in tissues such as testis and thymus. SIMILARITY: Belongs to the IL-15/IL-21 family. SEQUENCE CAUTION: Sequence=CAA71044.1; Type=Miscellaneous discrepancy; Note=Man-made cDNA construct with a sequence coding for signal peptide increasing the secretion of the protein (substitution with a signal peptide derived from the mouse IgV kappa chain); WEB RESOURCE: Name=R&D Systems' cytokine source book: IL-15; URL="http://www.rndsystems.com/molecule_detail.aspx?m=1671"; WEB RESOURCE: Name=Wikipedia; Note=Interleukin-15 entry; URL="http://en.wikipedia.org/wiki/Interleukin_15";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P40933
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001779 natural killer cell differentiation GO:0001866 NK T cell proliferation GO:0006954 inflammatory response GO:0006955 immune response GO:0007165 signal transduction GO:0007260 tyrosine phosphorylation of STAT protein GO:0007267 cell-cell signaling GO:0007568 aging GO:0008284 positive regulation of cell proliferation GO:0010469 regulation of receptor activity GO:0014732 skeletal muscle atrophy GO:0030212 hyaluronan metabolic process GO:0031667 response to nutrient levels GO:0032740 positive regulation of interleukin-17 production GO:0032819 positive regulation of natural killer cell proliferation GO:0032825 positive regulation of natural killer cell differentiation GO:0034105 positive regulation of tissue remodeling GO:0035723 interleukin-15-mediated signaling pathway GO:0042102 positive regulation of T cell proliferation GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0045062 extrathymic T cell selection GO:0045580 regulation of T cell differentiation GO:0048469 cell maturation GO:0048535 lymph node development GO:0048662 negative regulation of smooth muscle cell proliferation GO:0050691 regulation of defense response to virus by host GO:0050729 positive regulation of inflammatory response GO:0050778 positive regulation of immune response GO:0071305 cellular response to vitamin D GO:1904100 positive regulation of protein O-linked glycosylation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
