ID:IL16_HUMAN DESCRIPTION: RecName: Full=Pro-interleukin-16; Contains: RecName: Full=Interleukin-16; Short=IL-16; AltName: Full=Lymphocyte chemoattractant factor; Short=LCF; FUNCTION: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. FUNCTION: Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane. FUNCTION: Isoform 3 is involved in cell cycle progression in T- cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. SUBUNIT: Homotetramer (Probable). According to PubMed:9699630, the formation of a homotetrameric protein complex is not required for the chemo-attractant function. Isoform 3 interacts (via PDZ 3 domain) with PPP1R12A, PPP1R12B and PPP1R12C. Isoform 1 interacts with PPP1R12B. Isoform 3 interacts with GRIN2A. Isoform 3 interacts with GABPB1. Isoform 3 interacts (via PDZ 3 domain) with HDAC3. Isoform 1 interacts with GRIN2D, KCNJ10, KCNJ15 and CACNA1C (By similarity). Isoform 3 interacts with HTLV-1 tax. SUBCELLULAR LOCATION: Interleukin-16: Secreted. SUBCELLULAR LOCATION: Isoform 1: Cytoplasm (By similarity). SUBCELLULAR LOCATION: Isoform 3: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T-cell proliferation. INDUCTION: Isoform 3 is down-regulated in T-cells after TCR activation. PTM: Isoform 3 is synthesized as a chemo-attractant inactive precursor in hemopoietic tissues and is proteolytically cleaved by caspase-3 to yield IL-16. SIMILARITY: Contains 4 PDZ (DHR) domains. WEB RESOURCE: Name=R&D Systems' cytokine source book: IL-16; URL="http://www.rndsystems.com/molecule_detail.aspx?m=1673"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il16/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14005
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
