Human Gene IL17A (ENST00000648244.1_5) from GENCODE V47lift37
  Description: interleukin 17A (from RefSeq NM_002190.3)
Gencode Transcript: ENST00000648244.1_5
Gencode Gene: ENSG00000112115.7_10
Transcript (Including UTRs)
   Position: hg19 chr6:52,051,173-52,055,436 Size: 4,264 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr6:52,051,230-52,054,090 Size: 2,861 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:52,051,173-52,055,436)mRNA (may differ from genome)Protein (155 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: IL17_HUMAN
DESCRIPTION: RecName: Full=Interleukin-17A; Short=IL-17; Short=IL-17A; AltName: Full=Cytotoxic T-lymphocyte-associated antigen 8; Short=CTLA-8; Flags: Precursor;
FUNCTION: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Restricted to activated memory T-cells.
PTM: Found both in glycosylated and nonglycosylated forms.
SIMILARITY: Belongs to the IL-17 family.
WEB RESOURCE: Name=R&D Systems' cytokine mini-reviews: IL-17; URL="http://www.rndsystems.com/molecule_detail.aspx?m=1674";
WEB RESOURCE: Name=Wikipedia; Note=Interleukin-17 entry; URL="http://en.wikipedia.org/wiki/Interleukin_17";
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il17/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: IL17A
Diseases sorted by gene-association score: arthritis (27), aspiration pneumonia (21), bronchiolitis obliterans (21), acute generalized exanthematous pustulosis (18), rheumatoid arthritis (18), inflammatory bowel disease (15), allergic contact dermatitis (15), demyelinating disease (14), psoriasis (13), spondyloarthropathy (13), amebiasis (12), neurosyphilis (12), uveitis (12), radiculopathy (12), hidradenitis suppurativa (12), hidradenitis (11), panuveitis (11), osteonecrosis of the jaw (10), stromal keratitis (10), colitis (10), keratitis (10), hypersensitivity reaction type ii disease (10), cystic echinococcosis (10), chronic inflammatory demyelinating polyradiculoneuropathy (10), polyradiculoneuropathy (9), viral pneumonia (9), transverse myelitis (9), ileitis (9), chronic mucocutaneous candidiasis (8), allergic asthma (8), vogt-koyanagi-harada disease (8), alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity (8), autoimmune enteropathy (8), nasopharyngitis (8), neuromyelitis optica (8), hyper-ige recurrent infection syndrome (8), autoimmune polyendocrine syndrome (7), myelitis (7), autoimmune polyendocrine syndrome type 1 (7), mastitis (7), candidiasis (7), multiple sclerosis, disease progression, modifier of (7), opportunistic mycosis (7), nasopharyngeal disease (7), echinococcosis (7), periodontal disease (7), relapsing-remitting multiple sclerosis (7), spondyloarthropathy 1 (7), dermatomyositis (6), reactive arthritis (6), paranasal sinus disease (6), cutaneous candidiasis (6), trichosporonosis (6), contact dermatitis (6), lyme disease (6), periodontitis (6), rheumatoid lung disease (5), birdshot chorioretinopathy (5), spondylitis (5), joint disorders (5), yellow fever (5), conjunctival nevus (5), bone inflammation disease (5), ocular toxoplasmosis (5), extrinsic cardiomyopathy (5), infective endocarditis (5), intestinal disease (5), filamentary keratitis (5), septicemic plague (5), central nervous system vasculitis (4), myositis fibrosa (4), primary systemic mycosis (4), enterobiasis (4), asymptomatic neurosyphilis (4), lacrimal duct obstruction (4), type 1 diabetes mellitus 10 (4), eumycotic mycetoma (4), dermatitis (4), psoriatic arthritis (3), systemic lupus erythematosus (3), eye disease (2), asthma (2), autoinflammation, lipodystrophy, and dermatosis syndrome (2), malaria (2), respiratory system disease (2), central nervous system disease (2), hypersensitivity reaction disease (2), bronchial disease (1), upper respiratory tract disease (1), gastrointestinal system disease (1), immune system disease (1), primary bacterial infectious disease (1), behcet syndrome (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -5.1057-0.089 Picture PostScript Text
3' UTR -317.501346-0.236 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010345 - Interleukin-17
IPR020440 - Interleukin-17_chordata

Pfam Domains:
PF06083 - Interleukin-17

SCOP Domains:
50022 - ISP domain
57501 - Cystine-knot cytokines

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2VXS - X-ray


ModBase Predicted Comparative 3D Structure on Q16552
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005125 cytokine activity
GO:0005515 protein binding

Biological Process:
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007267 cell-cell signaling
GO:0008219 cell death
GO:0010469 regulation of receptor activity
GO:0019221 cytokine-mediated signaling pathway
GO:0032747 positive regulation of interleukin-23 production
GO:0045672 positive regulation of osteoclast differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050832 defense response to fungus
GO:0071347 cellular response to interleukin-1
GO:0072537 fibroblast activation
GO:0097400 interleukin-17-mediated signaling pathway
GO:1900017 positive regulation of cytokine production involved in inflammatory response
GO:2000778 positive regulation of interleukin-6 secretion

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009897 external side of plasma membrane


-  Descriptions from all associated GenBank mRNAs
  U32659 - Human IL-17 mRNA, complete cds.
BC066251 - Homo sapiens interleukin 17A, mRNA (cDNA clone MGC:79361 IMAGE:6971875), complete cds.
BC066252 - Homo sapiens interleukin 17A, mRNA (cDNA clone MGC:79362 IMAGE:6971876), complete cds.
BC066253 - Homo sapiens interleukin 17A, mRNA (cDNA clone MGC:79364 IMAGE:6971878), complete cds.
BC067503 - Homo sapiens interleukin 17A, mRNA (cDNA clone MGC:79363 IMAGE:6971877), complete cds.
BC067504 - Homo sapiens interleukin 17A, mRNA (cDNA clone MGC:79365 IMAGE:6971879), complete cds.
BC067505 - Homo sapiens interleukin 17A, mRNA (cDNA clone MGC:79367 IMAGE:6971881), complete cds.
Z58820 - H.sapiens CTLA8 mRNA.
AB590712 - Synthetic construct DNA, clone: pFN21AE1640, Homo sapiens IL17A gene for interleukin 17A, without stop codon, in Flexi system.
KJ905809 - Synthetic construct Homo sapiens clone ccsbBroadEn_15479 IL17A gene, encodes complete protein.
CU688116 - Synthetic construct Homo sapiens gateway clone IMAGE:100022939 5' read IL17A mRNA.
HQ447533 - Synthetic construct Homo sapiens clone IMAGE:100070872; CCSB014612_01 interleukin 17A (IL17A) gene, encodes complete protein.
KJ897053 - Synthetic construct Homo sapiens clone ccsbBroadEn_06447 IL17A gene, encodes complete protein.
HM535222 - Homo sapiens interleukin 17A mRNA, partial cds.
JD128307 - Sequence 109331 from Patent EP1572962.
JD387466 - Sequence 368490 from Patent EP1572962.
JD383497 - Sequence 364521 from Patent EP1572962.
JD203715 - Sequence 184739 from Patent EP1572962.
JD109831 - Sequence 90855 from Patent EP1572962.
JD067841 - Sequence 48865 from Patent EP1572962.
JD057617 - Sequence 38641 from Patent EP1572962.
JD312609 - Sequence 293633 from Patent EP1572962.
JD433875 - Sequence 414899 from Patent EP1572962.
JD553875 - Sequence 534899 from Patent EP1572962.
JD082725 - Sequence 63749 from Patent EP1572962.
JD288801 - Sequence 269825 from Patent EP1572962.
JD312687 - Sequence 293711 from Patent EP1572962.
JD348381 - Sequence 329405 from Patent EP1572962.
JD425034 - Sequence 406058 from Patent EP1572962.
JD411120 - Sequence 392144 from Patent EP1572962.
JD385492 - Sequence 366516 from Patent EP1572962.
JD174063 - Sequence 155087 from Patent EP1572962.
JD333529 - Sequence 314553 from Patent EP1572962.
JD039892 - Sequence 20916 from Patent EP1572962.
JD103164 - Sequence 84188 from Patent EP1572962.
JD291209 - Sequence 272233 from Patent EP1572962.
JD097089 - Sequence 78113 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_cytokinePathway - Cytokine Network
h_il17Pathway - IL 17 Signaling Pathway

Reactome (by CSHL, EBI, and GO)

Protein Q16552 (Reactome details) participates in the following event(s):

R-HSA-6785807 Interleukin-4 and 13 signaling
R-HSA-448424 Interleukin-17 signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: CTLA8, IL17, IL17_HUMAN, NM_002190, Q16552, Q5T2P0, uc328oob.1, uc328oob.2
UCSC ID: ENST00000648244.1_5
RefSeq Accession: NM_002190.3
Protein: Q16552 (aka IL17_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.