Human Gene IL18R1 (ENST00000233957.7_5) from GENCODE V47lift37
  Description: interleukin 18 receptor 1, transcript variant 1 (from RefSeq NM_003855.5)
Gencode Transcript: ENST00000233957.7_5
Gencode Gene: ENSG00000115604.12_11
Transcript (Including UTRs)
   Position: hg19 chr2:102,972,256-103,015,236 Size: 42,981 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr2:102,979,121-103,013,346 Size: 34,226 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:102,972,256-103,015,236)mRNA (may differ from genome)Protein (541 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: IL18R_HUMAN
DESCRIPTION: RecName: Full=Interleukin-18 receptor 1; Short=IL-18R-1; Short=IL-18R1; AltName: Full=CD218 antigen-like family member A; AltName: Full=CDw218a; AltName: Full=IL1 receptor-related protein; Short=IL-1Rrp; Short=IL1R-rp; AltName: CD_antigen=CD218a; Flags: Precursor;
FUNCTION: Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.
SUBUNIT: Does not bind IL1A/interleukin-1 alpha or IL1B/interleukin-1 beta.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression in Hodgkin disease cell lines.
SIMILARITY: Belongs to the interleukin-1 receptor family.
SIMILARITY: Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
SIMILARITY: Contains 1 TIR domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: IL18R1
Diseases sorted by gene-association score: smallpox (22), severe combined immune deficiency (11), acute basophilic leukemia (7), human monocytic ehrlichiosis (6), anthracosis (5), joint disorders (5), leukomalacia (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.39 RPKM in Whole Blood
Total median expression: 144.30 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -256.70633-0.406 Picture PostScript Text
3' UTR -516.001890-0.273 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR015621 - IL1-receptor_fam
IPR004075 - IL1_rcpt_1
IPR004074 - IL1_rcpt_I/II
IPR000157 - TIR_dom

Pfam Domains:
PF01582 - TIR domain
PF13676 - TIR domain

SCOP Domains:
48726 - Immunoglobulin
52200 - Toll/Interleukin receptor TIR domain

ModBase Predicted Comparative 3D Structure on Q13478
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004908 interleukin-1 receptor activity
GO:0005515 protein binding
GO:0038023 signaling receptor activity
GO:0042008 interleukin-18 receptor activity

Biological Process:
GO:0006955 immune response
GO:0007165 signal transduction
GO:0030101 natural killer cell activation
GO:0032729 positive regulation of interferon-gamma production
GO:0035655 interleukin-18-mediated signaling pathway
GO:0045063 T-helper 1 cell differentiation
GO:0071345 cellular response to cytokine stimulus
GO:1901224 positive regulation of NIK/NF-kappaB signaling

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK313967 - Homo sapiens cDNA, FLJ94614, Homo sapiens interleukin 18 receptor 1 (IL18R1), mRNA.
BC143403 - Homo sapiens interleukin 18 receptor 1, mRNA (cDNA clone MGC:176927 IMAGE:9051910), complete cds.
BC143405 - Homo sapiens cDNA clone IMAGE:9051912.
BC093977 - Homo sapiens interleukin 18 receptor 1, mRNA (cDNA clone MGC:121012 IMAGE:7939822), complete cds.
BC093975 - Homo sapiens interleukin 18 receptor 1, mRNA (cDNA clone MGC:121010 IMAGE:7939820), complete cds.
BC069575 - Homo sapiens interleukin 18 receptor 1, mRNA (cDNA clone MGC:97087 IMAGE:7262302), complete cds.
U43672 - Human putative transmembrane receptor IL-1Rrp mRNA, complete cds.
AB590640 - Synthetic construct DNA, clone: pFN21AE1973, Homo sapiens IL18R1 gene for interleukin 18 receptor 1, without stop codon, in Flexi system.
AY192162 - Homo sapiens putative soluble interleukin 18 receptor 1 (IL18R1) mRNA, complete cds.
KM264375 - Homo sapiens IL18Ralpha2 splice variant (IL18R1) mRNA, partial cds, alternatively spliced.
KM264374 - Homo sapiens IL18Ralpha2 splice variant (IL18R1) mRNA, partial cds, alternatively spliced.
JD427527 - Sequence 408551 from Patent EP1572962.
JD278563 - Sequence 259587 from Patent EP1572962.
JD329588 - Sequence 310612 from Patent EP1572962.
JD290100 - Sequence 271124 from Patent EP1572962.
JD041684 - Sequence 22708 from Patent EP1572962.
JD369881 - Sequence 350905 from Patent EP1572962.
JD232839 - Sequence 213863 from Patent EP1572962.
JD410430 - Sequence 391454 from Patent EP1572962.
JD207457 - Sequence 188481 from Patent EP1572962.
JD341849 - Sequence 322873 from Patent EP1572962.
JD115189 - Sequence 96213 from Patent EP1572962.
JD134191 - Sequence 115215 from Patent EP1572962.
JD197154 - Sequence 178178 from Patent EP1572962.
JD541582 - Sequence 522606 from Patent EP1572962.
JD539192 - Sequence 520216 from Patent EP1572962.
JD085381 - Sequence 66405 from Patent EP1572962.
JD306884 - Sequence 287908 from Patent EP1572962.
JD552642 - Sequence 533666 from Patent EP1572962.
JD496539 - Sequence 477563 from Patent EP1572962.
JD082069 - Sequence 63093 from Patent EP1572962.
JD349927 - Sequence 330951 from Patent EP1572962.
JD085544 - Sequence 66568 from Patent EP1572962.
JD251775 - Sequence 232799 from Patent EP1572962.
JD052071 - Sequence 33095 from Patent EP1572962.
JD548522 - Sequence 529546 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_th1th2Pathway - Th1/Th2 Differentiation
h_nktPathway - Selective expression of chemokine receptors during T-cell polarization
h_IL12Pathway - IL12 and Stat4 Dependent Signaling Pathway in Th1 Development

Reactome (by CSHL, EBI, and GO)

Protein Q13478 (Reactome details) participates in the following event(s):

R-HSA-8848335 IL37 binds IL18R1
R-HSA-8848370 IL18 binds IL18R1
R-HSA-8848395 IL18:IL18R1 binds IL18RAP
R-HSA-9008577 IL37:IL18R1 binds SIGIRR
R-HSA-9008059 Interleukin-37 signaling
R-HSA-9012546 Interleukin-18 signaling
R-HSA-446652 Interleukin-1 family signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: B2R9Y5, ENST00000233957.1, ENST00000233957.2, ENST00000233957.3, ENST00000233957.4, ENST00000233957.5, ENST00000233957.6, IL18R1 , IL18R_HUMAN, IL1RRP, NM_003855, Q13478, Q52LC9, uc317dyg.1, uc317dyg.2
UCSC ID: ENST00000233957.7_5
RefSeq Accession: NM_003855.5
Protein: Q13478 (aka IL18R_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.