Human Gene IL19 (ENST00000659997.3_6) from GENCODE V47lift37
  Description: interleukin 19, transcript variant 1 (from RefSeq NM_153758.5)
Gencode Transcript: ENST00000659997.3_6
Gencode Gene: ENSG00000142224.18_12
Transcript (Including UTRs)
   Position: hg19 chr1:206,944,118-207,016,326 Size: 72,209 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr1:207,010,008-207,015,967 Size: 5,960 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:206,944,118-207,016,326)mRNA (may differ from genome)Protein (177 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: IL19_HUMAN
DESCRIPTION: RecName: Full=Interleukin-19; Short=IL-19; AltName: Full=Melanoma differentiation-associated protein-like protein; AltName: Full=NG.1; Flags: Precursor;
FUNCTION: May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity).
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Belongs to the IL-10 family.
SEQUENCE CAUTION: Sequence=AAK91776.1; Type=Erroneous initiation;
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il19/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: IL19
Diseases sorted by gene-association score: spongiotic dermatitis (10), psoriasis (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -162.20454-0.357 Picture PostScript Text
3' UTR -102.20359-0.285 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009079 - 4_helix_cytokine-like_core
IPR012351 - 4_helix_cytokine_core
IPR020443 - Interleukin-10/19/20/24
IPR020423 - Interleukin-10_CS
IPR020421 - Interleukin-19

Pfam Domains:
PF00726 - Interleukin 10

SCOP Domains:
48334 - DNA repair protein MutS, domain III
47266 - 4-helical cytokines
158622 - YheA/YmcA-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1N1F - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q9UHD0
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005125 cytokine activity
GO:0005515 protein binding

Biological Process:
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0007165 signal transduction
GO:0010469 regulation of receptor activity
GO:0019221 cytokine-mediated signaling pathway
GO:0042226 interleukin-6 biosynthetic process
GO:0072593 reactive oxygen species metabolic process
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space


-  Descriptions from all associated GenBank mRNAs
  AY040367 - Homo sapiens interleukin 19 (IL19) mRNA, complete cds.
JD420009 - Sequence 401033 from Patent EP1572962.
AB463800 - Synthetic construct DNA, clone: pF1KB7441, Homo sapiens IL19 gene for interleukin 19, without stop codon, in Flexi system.
BC148534 - Synthetic construct Homo sapiens clone IMAGE:100015497, MGC:183061 interleukin 19 (IL19) mRNA, encodes complete protein.
BC153127 - Synthetic construct Homo sapiens clone IMAGE:100016494, MGC:184307 interleukin 19 (IL19) mRNA, encodes complete protein.
AF453946 - Homo sapiens interleukin 19 mRNA, complete cds.
AF192498 - Homo sapiens melanoma differentiation associated protein-like protein (ZMDA1) mRNA, complete cds.
FJ380053 - Homo sapiens interleukin 19 isoform 3 precursor (IL19) mRNA, complete cds, alternatively spliced.
JD509708 - Sequence 490732 from Patent EP1572962.
JD081024 - Sequence 62048 from Patent EP1572962.
JD100090 - Sequence 81114 from Patent EP1572962.
JD338437 - Sequence 319461 from Patent EP1572962.
JD082299 - Sequence 63323 from Patent EP1572962.
JD217107 - Sequence 198131 from Patent EP1572962.
JD481925 - Sequence 462949 from Patent EP1572962.
JD530695 - Sequence 511719 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9UHD0 (Reactome details) participates in the following event(s):

R-HSA-8982163 IL19:IL20RA:p‑JAK1:IL20RB:STAT3 phosphorylates STAT3
R-HSA-8854691 Interleukin-20 family signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: B6VEV9, ENST00000659997.1, ENST00000659997.2, IL19_HUMAN, NM_153758, Q5VUT3, Q96QR4, Q9NUA0, Q9UHD0, uc329ffv.1, uc329ffv.2, ZMDA1
UCSC ID: ENST00000659997.3_6
RefSeq Accession: NM_153758.5
Protein: Q9UHD0 (aka IL19_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.