ID:IL1B_HUMAN DESCRIPTION: RecName: Full=Interleukin-1 beta; Short=IL-1 beta; AltName: Full=Catabolin; Flags: Precursor; FUNCTION: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. SUBUNIT: Monomer. SUBCELLULAR LOCATION: Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. DOMAIN: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function. SIMILARITY: Belongs to the IL-1 family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org//Genes/IL1BID40950ch2q13.html"; WEB RESOURCE: Name=Wikipedia; Note=Interleukin-1 entry; URL="http://en.wikipedia.org/wiki/Interleukin_1"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il1b/"; WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL1B";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P01584
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000165 MAPK cascade GO:0000187 activation of MAPK activity GO:0001660 fever generation GO:0001934 positive regulation of protein phosphorylation GO:0002711 positive regulation of T cell mediated immunity GO:0006915 apoptotic process GO:0006954 inflammatory response GO:0006955 immune response GO:0007165 signal transduction GO:0007267 cell-cell signaling GO:0007566 embryo implantation GO:0008284 positive regulation of cell proliferation GO:0008285 negative regulation of cell proliferation GO:0009743 response to carbohydrate GO:0010469 regulation of receptor activity GO:0010575 positive regulation of vascular endothelial growth factor production GO:0010628 positive regulation of gene expression GO:0010718 positive regulation of epithelial to mesenchymal transition GO:0010829 negative regulation of glucose transport GO:0014805 smooth muscle adaptation GO:0019221 cytokine-mediated signaling pathway GO:0030213 hyaluronan biosynthetic process GO:0030335 positive regulation of cell migration GO:0030593 neutrophil chemotaxis GO:0030730 sequestering of triglyceride GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0031622 positive regulation of fever generation GO:0031663 lipopolysaccharide-mediated signaling pathway GO:0032308 positive regulation of prostaglandin secretion GO:0032496 response to lipopolysaccharide GO:0032611 interleukin-1 beta production GO:0032635 interleukin-6 production GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032729 positive regulation of interferon-gamma production GO:0032755 positive regulation of interleukin-6 production GO:0032757 positive regulation of interleukin-8 production GO:0033129 positive regulation of histone phosphorylation GO:0033198 response to ATP GO:0034116 positive regulation of heterotypic cell-cell adhesion GO:0035066 positive regulation of histone acetylation GO:0035234 ectopic germ cell programmed cell death GO:0035505 positive regulation of myosin light chain kinase activity GO:0035690 cellular response to drug GO:0042102 positive regulation of T cell proliferation GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043407 negative regulation of MAP kinase activity GO:0043491 protein kinase B signaling GO:0045080 positive regulation of chemokine biosynthetic process GO:0045086 positive regulation of interleukin-2 biosynthetic process GO:0045410 positive regulation of interleukin-6 biosynthetic process GO:0045429 positive regulation of nitric oxide biosynthetic process GO:0045766 positive regulation of angiogenesis GO:0045833 negative regulation of lipid metabolic process GO:0045840 positive regulation of mitotic nuclear division GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046330 positive regulation of JNK cascade GO:0046627 negative regulation of insulin receptor signaling pathway GO:0046827 positive regulation of protein export from nucleus GO:0050691 regulation of defense response to virus by host GO:0050766 positive regulation of phagocytosis GO:0050796 regulation of insulin secretion GO:0050805 negative regulation of synaptic transmission GO:0050900 leukocyte migration GO:0050995 negative regulation of lipid catabolic process GO:0050996 positive regulation of lipid catabolic process GO:0050999 regulation of nitric-oxide synthase activity GO:0051044 positive regulation of membrane protein ectodomain proteolysis GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0051781 positive regulation of cell division GO:0060355 positive regulation of cell adhesion molecule production GO:0060559 positive regulation of calcidiol 1-monooxygenase activity GO:0070164 negative regulation of adiponectin secretion GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070487 monocyte aggregation GO:0070498 interleukin-1-mediated signaling pathway GO:0071260 cellular response to mechanical stimulus GO:0071310 cellular response to organic substance GO:0071407 cellular response to organic cyclic compound GO:0071639 positive regulation of monocyte chemotactic protein-1 production GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand GO:1900745 positive regulation of p38MAPK cascade GO:1901224 positive regulation of NIK/NF-kappaB signaling GO:1903140 regulation of establishment of endothelial barrier GO:2000778 positive regulation of interleukin-6 secretion GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
