Human Gene IL1R2 (ENST00000332549.8_4) from GENCODE V47lift37
  Description: interleukin 1 receptor type 2, transcript variant 1 (from RefSeq NM_004633.4)
Gencode Transcript: ENST00000332549.8_4
Gencode Gene: ENSG00000115590.14_12
Transcript (Including UTRs)
   Position: hg19 chr2:102,608,422-102,645,006 Size: 36,585 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr2:102,625,038-102,644,854 Size: 19,817 Coding Exon Count: 8 

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Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:102,608,422-102,645,006)mRNA (may differ from genome)Protein (398 aa)
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-  Comments and Description Text from UniProtKB
  ID: IL1R2_HUMAN
DESCRIPTION: RecName: Full=Interleukin-1 receptor type 2; Short=IL-1R-2; Short=IL-1RT-2; Short=IL-1RT2; AltName: Full=CD121 antigen-like family member B; AltName: Full=CDw121b; AltName: Full=IL-1 type II receptor; AltName: Full=Interleukin-1 receptor beta; Short=IL-1R-beta; AltName: Full=Interleukin-1 receptor type II; AltName: CD_antigen=CD121b; Contains: RecName: Full=Interleukin-1 receptor type 2, membrane form; Short=mIL-1R2; Short=mIL-1RII; Contains: RecName: Full=Interleukin-1 receptor type 2, soluble form; Short=sIL-1R2; Short=sIL-1RII; Flags: Precursor;
FUNCTION: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
SUBUNIT: Associates with IL1RAP to form a non-signaling interleukin-1 receptor complex.
SUBCELLULAR LOCATION: Isoform Short: Secreted.
SUBCELLULAR LOCATION: Isoform Long: Cell membrane; Single-pass type I membrane protein.
PTM: A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported.
SIMILARITY: Belongs to the interleukin-1 receptor family.
SIMILARITY: Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il1r2/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: IL1R2
Diseases sorted by gene-association score: endometriosis (5), joint disorders (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 193.30 RPKM in Whole Blood
Total median expression: 360.93 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -37.60113-0.333 Picture PostScript Text
3' UTR -36.00152-0.237 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR015621 - IL1-receptor_fam
IPR004074 - IL1_rcpt_I/II
IPR013151 - Immunoglobulin
IPR004077 - Interleukin-1_rcpt_II

Pfam Domains:
PF00047 - Immunoglobulin domain
PF18452 - Immunoglobulin domain

SCOP Domains:
48726 - Immunoglobulin

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3O4O - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P27930
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004908 interleukin-1 receptor activity
GO:0004910 interleukin-1, Type II, blocking receptor activity
GO:0005515 protein binding
GO:0019966 interleukin-1 binding

Biological Process:
GO:0006955 immune response
GO:0010955 negative regulation of protein processing
GO:0019221 cytokine-mediated signaling pathway
GO:0050712 negative regulation of interleukin-1 alpha secretion
GO:0070498 interleukin-1-mediated signaling pathway
GO:1900016 negative regulation of cytokine production involved in inflammatory response
GO:2000660 negative regulation of interleukin-1-mediated signaling pathway

Cellular Component:
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC039031 - Homo sapiens interleukin 1 receptor, type II, mRNA (cDNA clone MGC:47725 IMAGE:5723005), complete cds.
AK309161 - Homo sapiens cDNA, FLJ99202.
AK130412 - Homo sapiens cDNA FLJ26902 fis, clone RCT01275, highly similar to Interleukin-1 receptor, type II precursor.
BC027733 - Homo sapiens interleukin 1 receptor, type II, mRNA (cDNA clone IMAGE:4546395), partial cds.
BC012346 - Homo sapiens cDNA clone IMAGE:4562827, containing frame-shift errors.
U64094 - Human soluble type II interleukin-1 receptor mRNA, complete cds.
X59770 - H.sapiens IL-1R2 mRNA for type II interleukin-1 receptor, (cell line CB23).
U74649 - Human interleukin-1 receptor type II mRNA, complete cds.
CU691642 - Synthetic construct Homo sapiens gateway clone IMAGE:100020922 5' read IL1R2 mRNA.
AB590639 - Synthetic construct DNA, clone: pFN21AE1878, Homo sapiens IL1R2 gene for interleukin 1 receptor, type II, without stop codon, in Flexi system.
HQ448529 - Synthetic construct Homo sapiens clone IMAGE:100071964; CCSB010293_01 interleukin 1 receptor, type II (IL1R2) gene, encodes complete protein.
KJ892439 - Synthetic construct Homo sapiens clone ccsbBroadEn_01833 IL1R2 gene, encodes complete protein.
FJ200480 - Homo sapiens interleukin 1 receptor type II variant 3 (IL1R2c) mRNA, complete cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P27930 (Reactome details) participates in the following event(s):

R-HSA-446130 Interleukin-1 receptor type 2 binds Interleukin 1
R-HSA-445757 IL1 receptor antagonist protein binds Interleukin 1 receptors
R-HSA-9020702 Interleukin-1 signaling
R-HSA-6783783 Interleukin-10 signaling
R-HSA-446652 Interleukin-1 family signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: D3DVJ5, ENST00000332549.1, ENST00000332549.2, ENST00000332549.3, ENST00000332549.4, ENST00000332549.5, ENST00000332549.6, ENST00000332549.7, IL1R2_HUMAN, IL1RB, NM_004633, P27930, Q6LCE6, Q9UE68, uc317tlt.1, uc317tlt.2
UCSC ID: ENST00000332549.8_4
RefSeq Accession: NM_004633.4
Protein: P27930 (aka IL1R2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.