ID:IL1RA_HUMAN DESCRIPTION: RecName: Full=Interleukin-1 receptor antagonist protein; Short=IL-1RN; Short=IL-1ra; Short=IRAP; AltName: Full=ICIL-1RA; AltName: Full=IL1 inhibitor; AltName: INN=Anakinra; Flags: Precursor; FUNCTION: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. SUBCELLULAR LOCATION: Isoform 1: Secreted. SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. SUBCELLULAR LOCATION: Isoform 3: Cytoplasm. SUBCELLULAR LOCATION: Isoform 4: Cytoplasm. TISSUE SPECIFICITY: The intracellular form of IL1RN is predominantly expressed in epithelial cells. DISEASE: Genetic variation in IL1RN is associated with susceptibility to microvascular complications of diabetes type 4 (MVCD4) [MIM:612628]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new- onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. DISEASE: Defects in IL1RN are the cause of interleukin 1 receptor antagonist deficiency (DIRA) [MIM:612852]; also known as deficiency of interleukin 1 receptor antagonist. Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T-cells. DIRA is a rare, autosomal recessive, genetic autoinflammatory disease that results in sterile multifocal osteomyelitis (bone inflammation in multiple places), periostitis (inflammation of the membrane surrounding the bones), and pustulosis (due to skin inflammation) from birth. PHARMACEUTICAL: Available under the name Kineret (Amgen). Used for the reduction in signs and symptoms and slowing the progression of structural damage in moderately to severely active rheumatoid arthritis. WEB RESOURCE: Name=R&D Systems' cytokine source book: IL-1ra; URL="http://www.rndsystems.com/molecule_detail.aspx?m=1637"; WEB RESOURCE: Name=Wikipedia; Note=Interleukin-1 entry; URL="http://en.wikipedia.org/wiki/Interleukin_1"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il1rn/"; WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL1RN"; WEB RESOURCE: Name=Kineret professional medical information"; URL="http://www.rxlist.com/kineret-drug.htm";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P18510
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005125 cytokine activity GO:0005149 interleukin-1 receptor binding GO:0005150 interleukin-1, Type I receptor binding GO:0005151 interleukin-1, Type II receptor binding GO:0005152 interleukin-1 receptor antagonist activity GO:0005515 protein binding GO:0045352 interleukin-1 Type I receptor antagonist activity GO:0045353 interleukin-1 Type II receptor antagonist activity
Biological Process: GO:0001660 fever generation GO:0001960 negative regulation of cytokine-mediated signaling pathway GO:0006629 lipid metabolic process GO:0006953 acute-phase response GO:0006954 inflammatory response GO:0006955 immune response GO:0010469 regulation of receptor activity GO:0019221 cytokine-mediated signaling pathway GO:0030073 insulin secretion GO:0034115 negative regulation of heterotypic cell-cell adhesion GO:0051384 response to glucocorticoid GO:0070498 interleukin-1-mediated signaling pathway GO:2000660 negative regulation of interleukin-1-mediated signaling pathway
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
