ID:IL21_HUMAN DESCRIPTION: RecName: Full=Interleukin-21; Short=IL-21; AltName: Full=Za11; Flags: Precursor; FUNCTION: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. SIMILARITY: Belongs to the IL-15/IL-21 family. SEQUENCE CAUTION: Sequence=AAG29348.1; Type=Erroneous initiation; Sequence=AAH66258.1; Type=Erroneous initiation; Sequence=AAH66259.1; Type=Erroneous initiation; Sequence=AAH66260.1; Type=Erroneous initiation; Sequence=AAH66261.1; Type=Erroneous initiation; Sequence=AAH66262.1; Type=Erroneous initiation; Sequence=AAH69124.1; Type=Erroneous initiation; Sequence=AAU88182.1; Type=Erroneous initiation; Sequence=ABG36529.1; Type=Erroneous initiation; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il21/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9HBE4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001819 positive regulation of cytokine production GO:0006955 immune response GO:0007165 signal transduction GO:0007260 tyrosine phosphorylation of STAT protein GO:0008284 positive regulation of cell proliferation GO:0010469 regulation of receptor activity GO:0030890 positive regulation of B cell proliferation GO:0032740 positive regulation of interleukin-17 production GO:0034105 positive regulation of tissue remodeling GO:0038114 interleukin-21-mediated signaling pathway GO:0042102 positive regulation of T cell proliferation GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0045078 positive regulation of interferon-gamma biosynthetic process GO:0045954 positive regulation of natural killer cell mediated cytotoxicity GO:0048469 cell maturation GO:0050729 positive regulation of inflammatory response
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
