Human Gene IL22 (ENST00000538666.6_8) from GENCODE V47lift37
  Description: interleukin 22 (from RefSeq NM_020525.5)
Gencode Transcript: ENST00000538666.6_8
Gencode Gene: ENSG00000127318.11_11
Transcript (Including UTRs)
   Position: hg19 chr12:68,642,022-68,647,384 Size: 5,363 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr12:68,642,579-68,647,228 Size: 4,650 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:68,642,022-68,647,384)mRNA (may differ from genome)Protein (179 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: IL22_HUMAN
DESCRIPTION: RecName: Full=Interleukin-22; Short=IL-22; AltName: Full=Cytokine Zcyto18; AltName: Full=IL-10-related T-cell-derived-inducible factor; Short=IL-TIF; Flags: Precursor;
FUNCTION: Cytokine that contributes to the inflammatory response in vivo.
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Belongs to the IL-10 family.
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il22/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: IL22
Diseases sorted by gene-association score: scleritis (15), inflammatory bowel disease (10), acute generalized exanthematous pustulosis (9), chronic mucocutaneous candidiasis (8), autoimmune polyendocrine syndrome (7), alcoholic hepatitis (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.13 RPKM in Testis
Total median expression: 0.35 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -11.0068-0.162 Picture PostScript Text
3' UTR -92.90557-0.167 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009079 - 4_helix_cytokine-like_core
IPR012351 - 4_helix_cytokine_core
IPR020423 - Interleukin-10_CS
IPR020453 - Interleukin-22

Pfam Domains:
PF14565 - Interleukin 22 IL-10-related T-cell-derived-inducible factor

SCOP Domains:
47266 - 4-helical cytokines

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1M4R - X-ray MuPIT 1YKB - X-ray MuPIT 3DGC - X-ray 3DLQ - X-ray MuPIT 3G9V - X-ray MuPIT 3Q1S - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q9GZX6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0045518 interleukin-22 receptor binding

Biological Process:
GO:0006953 acute-phase response
GO:0006954 inflammatory response
GO:0010469 regulation of receptor activity
GO:0019221 cytokine-mediated signaling pathway
GO:0051384 response to glucocorticoid

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space


-  Descriptions from all associated GenBank mRNAs
  AF279437 - Homo sapiens interleukin 22 (IL22) mRNA, complete cds.
AY358890 - Homo sapiens clone DNA125185 IL22 (UNQ3099) mRNA, complete cds.
BC070261 - Homo sapiens interleukin 22, mRNA (cDNA clone MGC:88248 IMAGE:30416027), complete cds.
AJ277247 - Homo sapiens mRNA for interleukin 22 (IL-22 gene).
BC069112 - Homo sapiens interleukin 22, mRNA (cDNA clone MGC:95390 IMAGE:7216929), complete cds.
BC069308 - Homo sapiens interleukin 22, mRNA (cDNA clone MGC:96918 IMAGE:7262127), complete cds.
BC066264 - Homo sapiens interleukin 22, mRNA (cDNA clone MGC:79383 IMAGE:6971855), complete cds.
BC066263 - Homo sapiens interleukin 22, mRNA (cDNA clone MGC:79382 IMAGE:6971854), complete cds.
BC066265 - Homo sapiens interleukin 22, mRNA (cDNA clone MGC:79384 IMAGE:6971857), complete cds.
BC066266 - Homo sapiens cDNA clone IMAGE:6971860, containing frame-shift errors.
BC067510 - Homo sapiens interleukin 22, mRNA (cDNA clone MGC:79386 IMAGE:6971859), complete cds.
BC067509 - Homo sapiens interleukin 22, mRNA (cDNA clone MGC:79385 IMAGE:6971858), complete cds.
HQ448427 - Synthetic construct Homo sapiens clone IMAGE:100071855; CCSB013809_02 interleukin 22 (IL22) gene, encodes complete protein.
CU686738 - Synthetic construct Homo sapiens gateway clone IMAGE:100022568 5' read IL22 mRNA.
AB590805 - Synthetic construct DNA, clone: pFN21AE1661, Homo sapiens IL22 gene for interleukin 22, without stop codon, in Flexi system.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9GZX6 (Reactome details) participates in the following event(s):

R-HSA-448480 IL22 binds IL22RA1:JAK1 receptor complex
R-HSA-448741 IL22RA2 binds IL22
R-HSA-8854645 IL22:IL22RA1:JAK1 binds IL10RB:TYK2
R-HSA-8987132 IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11
R-HSA-8854691 Interleukin-20 family signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000538666.1, ENST00000538666.2, ENST00000538666.3, ENST00000538666.4, ENST00000538666.5, IL22_HUMAN, ILTIF, NM_020525, Q9GZX6, uc324qrk.1, uc324qrk.2, UNQ3099/PRO10096, ZCYTO18
UCSC ID: ENST00000538666.6_8
RefSeq Accession: NM_020525.5
Protein: Q9GZX6 (aka IL22_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.