Human Gene IL24 (ENST00000294984.7_9) from GENCODE V47lift37
  Description: interleukin 24, transcript variant 1 (from RefSeq NM_006850.3)
Gencode Transcript: ENST00000294984.7_9
Gencode Gene: ENSG00000162892.16_13
Transcript (Including UTRs)
   Position: hg19 chr1:207,070,788-207,077,484 Size: 6,697 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr1:207,071,178-207,076,404 Size: 5,227 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:207,070,788-207,077,484)mRNA (may differ from genome)Protein (206 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: IL24_HUMAN
DESCRIPTION: RecName: Full=Interleukin-24; Short=IL-24; AltName: Full=Melanoma differentiation-associated gene 7 protein; Short=MDA-7; AltName: Full=Suppression of tumorigenicity 16 protein; Flags: Precursor;
FUNCTION: Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.
SUBCELLULAR LOCATION: Secreted (Potential).
TISSUE SPECIFICITY: Up-regulated in melanoma cells induced to terminally differentiate.
SIMILARITY: Belongs to the IL-10 family.
WEB RESOURCE: Name=Wikipedia; Note=Interleukin-24 entry; URL="http://en.wikipedia.org/wiki/Interleukin_24";
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il24/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: IL24
Diseases sorted by gene-association score: melanoma (14), subclavian steal syndrome (4), petrous apex meningioma (4), pancreatic cancer (3), lung cancer (2), blount's disease (2), chorioangioma (1), patella, chondromalacia of (1), hemangioma of intra-abdominal structure (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D014013 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C012796 2-butenal
  • C120943 2-hydroxymethyl-4,8-dihydrobenzo(1,2-b-5,4-b')dithiophene-48-dione
  • D015112 4-Nitroquinoline-1-oxide
  • C002202 4-oxoretinoic acid
  • D015127 9,10-Dimethyl-1,2-benzanthracene
  • D000111 Acetylcysteine
  • D000643 Ammonium Chloride
  • D017638 Asbestos, Crocidolite
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.02 RPKM in Spleen
Total median expression: 56.04 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -87.60275-0.319 Picture PostScript Text
3' UTR -309.101080-0.286 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009079 - 4_helix_cytokine-like_core
IPR012351 - 4_helix_cytokine_core
IPR020443 - Interleukin-10/19/20/24
IPR020423 - Interleukin-10_CS
IPR020444 - Interleukin-24

SCOP Domains:
47266 - 4-helical cytokines

ModBase Predicted Comparative 3D Structure on Q13007
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005125 cytokine activity
GO:0005515 protein binding

Biological Process:
GO:0006915 apoptotic process
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010469 regulation of receptor activity
GO:0019221 cytokine-mediated signaling pathway
GO:0030336 negative regulation of cell migration
GO:0042060 wound healing
GO:0042501 serine phosphorylation of STAT protein
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0071222 cellular response to lipopolysaccharide
GO:0071353 cellular response to interleukin-4

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space


-  Descriptions from all associated GenBank mRNAs
  U16261 - Human MDA-7 (mda-7) mRNA, complete cds.
AY641440 - Homo sapiens IL-24 splice variant delE3 mRNA, complete cds, alternatively spliced.
AY641441 - Homo sapiens IL-24 splice variant delE5 mRNA, complete cds, alternatively spliced.
BC009681 - Homo sapiens interleukin 24, mRNA (cDNA clone MGC:8926 IMAGE:3878467), complete cds.
JD407876 - Sequence 388900 from Patent EP1572962.
JD302000 - Sequence 283024 from Patent EP1572962.
JD053601 - Sequence 34625 from Patent EP1572962.
JD465674 - Sequence 446698 from Patent EP1572962.
AY237723 - Homo sapiens melanocyte-associated Mda-7 splice variant mRNA, complete cds, alternatively spliced.
AB590386 - Synthetic construct DNA, clone: pFN21AE2158, Homo sapiens IL24 gene for interleukin 24, without stop codon, in Flexi system.
BT007156 - Homo sapiens interleukin 24 mRNA, complete cds.
DQ890656 - Synthetic construct Homo sapiens clone IMAGE:100003286; FLH263522.01X; RZPDo839C07158D interleukin 24 (IL24) gene, encodes complete protein.
DQ890657 - Synthetic construct clone IMAGE:100003287; FLH164835.01X; RZPDo839C08158D interleukin 24 (IL24) gene, encodes complete protein.
DQ893836 - Synthetic construct Homo sapiens clone IMAGE:100008296; FLH164831.01L; RZPDo839C08157D interleukin 24 (IL24) gene, encodes complete protein.
DQ893843 - Synthetic construct Homo sapiens clone IMAGE:100008303; FLH263723.01L; RZPDo839D04157D interleukin 24 (IL24) gene, encodes complete protein.
JD373439 - Sequence 354463 from Patent EP1572962.
JD417809 - Sequence 398833 from Patent EP1572962.
JD375036 - Sequence 356060 from Patent EP1572962.
JD400803 - Sequence 381827 from Patent EP1572962.
JD214701 - Sequence 195725 from Patent EP1572962.
JD266225 - Sequence 247249 from Patent EP1572962.
JD429981 - Sequence 411005 from Patent EP1572962.
JD354873 - Sequence 335897 from Patent EP1572962.
JD156378 - Sequence 137402 from Patent EP1572962.
JD453202 - Sequence 434226 from Patent EP1572962.
JD557113 - Sequence 538137 from Patent EP1572962.
JD046194 - Sequence 27218 from Patent EP1572962.
JD081292 - Sequence 62316 from Patent EP1572962.
JD040644 - Sequence 21668 from Patent EP1572962.
JD197930 - Sequence 178954 from Patent EP1572962.
JD111192 - Sequence 92216 from Patent EP1572962.
JD400747 - Sequence 381771 from Patent EP1572962.
JD233712 - Sequence 214736 from Patent EP1572962.
JD352251 - Sequence 333275 from Patent EP1572962.
JD321360 - Sequence 302384 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q13007 (Reactome details) participates in the following event(s):

R-HSA-8987129 JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated
R-HSA-8854691 Interleukin-20 family signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000294984.1, ENST00000294984.2, ENST00000294984.3, ENST00000294984.4, ENST00000294984.5, ENST00000294984.6, IL24_HUMAN, MDA7, NM_006850, Q13007, Q2YHE5, Q53XZ7, Q5YLN8, Q96DB0, Q96KG4, ST16, uc317lix.1, uc317lix.2
UCSC ID: ENST00000294984.7_9
RefSeq Accession: NM_006850.3
Protein: Q13007 (aka IL24_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.