Human Gene IL26 (ENST00000229134.5_7) from GENCODE V47lift37
  Description: interleukin 26 (from RefSeq NM_018402.2)
Gencode Transcript: ENST00000229134.5_7
Gencode Gene: ENSG00000111536.5_9
Transcript (Including UTRs)
   Position: hg19 chr12:68,595,129-68,619,590 Size: 24,462 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr12:68,595,625-68,619,536 Size: 23,912 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:68,595,129-68,619,590)mRNA (may differ from genome)Protein (171 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedReactomeUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: IL26_HUMAN
DESCRIPTION: RecName: Full=Interleukin-26; Short=IL-26; AltName: Full=Protein AK155; Flags: Precursor;
FUNCTION: May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in serum of patients with Crohn's disease (at protein level).
INDUCTION: By Herpesvirus saimiri infection.
SIMILARITY: Belongs to the IL-10 family.
WEB RESOURCE: Name=Wikipedia; Note=Interleukin-26 entry; URL="http://en.wikipedia.org/wiki/Interleukin_26";
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il26/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.11 RPKM in Spleen
Total median expression: 0.57 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -14.1054-0.261 Picture PostScript Text
3' UTR -97.10496-0.196 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009079 - 4_helix_cytokine-like_core
IPR012351 - 4_helix_cytokine_core
IPR020443 - Interleukin-10/19/20/24
IPR020423 - Interleukin-10_CS

Pfam Domains:
PF00726 - Interleukin 10

SCOP Domains:
47266 - 4-helical cytokines

ModBase Predicted Comparative 3D Structure on Q9NPH9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005125 cytokine activity

Biological Process:
GO:0007267 cell-cell signaling
GO:0010469 regulation of receptor activity
GO:0019221 cytokine-mediated signaling pathway
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046427 positive regulation of JAK-STAT cascade
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050715 positive regulation of cytokine secretion
GO:0051897 positive regulation of protein kinase B signaling
GO:0070374 positive regulation of ERK1 and ERK2 cascade

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  KJ894263 - Synthetic construct Homo sapiens clone ccsbBroadEn_03657 IL26 gene, encodes complete protein.
KJ906244 - Synthetic construct Homo sapiens clone ccsbBroadEn_15914 IL26 gene, encodes complete protein.
AJ251549 - Homo sapiens mRNA for AK155 protein (AK155 gene).
JD222613 - Sequence 203637 from Patent EP1572962.
JD120073 - Sequence 101097 from Patent EP1572962.
JD554416 - Sequence 535440 from Patent EP1572962.
JD168152 - Sequence 149176 from Patent EP1572962.
JD345230 - Sequence 326254 from Patent EP1572962.
BC066270 - Homo sapiens interleukin 26, mRNA (cDNA clone MGC:79394 IMAGE:7002121), complete cds.
BC066271 - Homo sapiens interleukin 26, mRNA (cDNA clone MGC:79395 IMAGE:7002122), complete cds.
CU688126 - Synthetic construct Homo sapiens gateway clone IMAGE:100022921 5' read IL26 mRNA.
CU688128 - Synthetic construct Homo sapiens gateway clone IMAGE:100022930 5' read IL26 mRNA.
HQ447556 - Synthetic construct Homo sapiens clone IMAGE:100070896; CCSB014585_01 interleukin 26 (IL26) gene, encodes complete protein.
JD140753 - Sequence 121777 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9NPH9 (Reactome details) participates in the following event(s):

R-HSA-8986480 IL26:IL20RA:JAK1 binds IL10RB:TYK2
R-HSA-8854691 Interleukin-20 family signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: AK155, ENST00000229134.1, ENST00000229134.2, ENST00000229134.3, ENST00000229134.4, IL26_HUMAN, NM_018402, Q9NPH9, uc317dpo.1, uc317dpo.2
UCSC ID: ENST00000229134.5_7
RefSeq Accession: NM_018402.2
Protein: Q9NPH9 (aka IL26_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.