ID:IL2RA_HUMAN DESCRIPTION: RecName: Full=Interleukin-2 receptor subunit alpha; Short=IL-2 receptor subunit alpha; Short=IL-2-RA; Short=IL-2R subunit alpha; Short=IL2-RA; AltName: Full=TAC antigen; AltName: Full=p55; AltName: CD_antigen=CD25; Flags: Precursor; FUNCTION: Receptor for interleukin-2. SUBUNIT: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. DISEASE: Genetic variations in IL2RA are associated with susceptibility to diabetes mellitus insulin-dependent type 10 (IDDM10) [MIM:601942]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. SIMILARITY: Contains 2 Sushi (CCP/SCR) domains. WEB RESOURCE: Name=IL2RAbase; Note=IL2RA mutation db; URL="http://bioinf.uta.fi/IL2RAbase/"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il2ra/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P01589
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000165 MAPK cascade GO:0002376 immune system process GO:0002437 inflammatory response to antigenic stimulus GO:0002664 regulation of T cell tolerance induction GO:0006915 apoptotic process GO:0006924 activation-induced cell death of T cells GO:0006954 inflammatory response GO:0006955 immune response GO:0007166 cell surface receptor signaling pathway GO:0007219 Notch signaling pathway GO:0008283 cell proliferation GO:0019221 cytokine-mediated signaling pathway GO:0038110 interleukin-2-mediated signaling pathway GO:0042102 positive regulation of T cell proliferation GO:0042104 positive regulation of activated T cell proliferation GO:0042130 negative regulation of T cell proliferation GO:0043029 T cell homeostasis GO:0045582 positive regulation of T cell differentiation GO:0045589 regulation of regulatory T cell differentiation GO:0046013 regulation of T cell homeostatic proliferation GO:0050672 negative regulation of lymphocyte proliferation GO:0050687 negative regulation of defense response to virus GO:0050728 negative regulation of inflammatory response GO:0050777 negative regulation of immune response
X01057 - Human mRNA for interleukin-2 receptor. JD517499 - Sequence 498523 from Patent EP1572962. JD500561 - Sequence 481585 from Patent EP1572962. JD388475 - Sequence 369499 from Patent EP1572962. JD558819 - Sequence 539843 from Patent EP1572962. JD431011 - Sequence 412035 from Patent EP1572962. JD243342 - Sequence 224366 from Patent EP1572962. JD225785 - Sequence 206809 from Patent EP1572962. JD136287 - Sequence 117311 from Patent EP1572962. JD222746 - Sequence 203770 from Patent EP1572962. JD274263 - Sequence 255287 from Patent EP1572962. JD402025 - Sequence 383049 from Patent EP1572962. JD205602 - Sequence 186626 from Patent EP1572962. JD130960 - Sequence 111984 from Patent EP1572962. JD515154 - Sequence 496178 from Patent EP1572962. JD543046 - Sequence 524070 from Patent EP1572962. JD142558 - Sequence 123582 from Patent EP1572962. JD495011 - Sequence 476035 from Patent EP1572962. JD468947 - Sequence 449971 from Patent EP1572962. JD541591 - Sequence 522615 from Patent EP1572962. K03122 - Human interleukin-2 receptor mRNA (short form), complete cds. JD036864 - Sequence 17888 from Patent EP1572962. JD122695 - Sequence 103719 from Patent EP1572962. JD040458 - Sequence 21482 from Patent EP1572962. AK223313 - Homo sapiens mRNA for interleukin 2 receptor, alpha chain precursor variant, clone: TMS04728. JD458806 - Sequence 439830 from Patent EP1572962. JD232036 - Sequence 213060 from Patent EP1572962. JD038506 - Sequence 19530 from Patent EP1572962. E00723 - cDNA encoding human interleukin-2 receptor. E02541 - cDNA encoding human Interleukin-2 receptor L chain. E09577 - cDNA encoding human interleukin-2 receptor. JD304543 - Sequence 285567 from Patent EP1572962. JD403525 - Sequence 384549 from Patent EP1572962. JD052392 - Sequence 33416 from Patent EP1572962. M14098 - Human T-cell interleukin-2 receptor mRNA, mature peptide region. AK313847 - Homo sapiens cDNA, FLJ94475, highly similar to Homo sapiens interleukin 2 receptor, alpha (IL2RA), mRNA. BC156627 - Synthetic construct Homo sapiens clone IMAGE:100062063, MGC:190156 interleukin 2 receptor, alpha (IL2RA) mRNA, encodes complete protein. BC152889 - Synthetic construct Homo sapiens clone IMAGE:100016079, MGC:184222 interleukin 2 receptor, alpha (IL2RA) mRNA, encodes complete protein. AB528862 - Synthetic construct DNA, clone: pF1KE0583, Homo sapiens IL2RA gene for interleukin 2 receptor, alpha, without stop codon, in Flexi system. E00727 - cDNA encoding human IL-2 receptor. AF008556 - Homo sapiens interleukin-2 receptor mRNA, alternatively spliced, partial cds. JD407890 - Sequence 388914 from Patent EP1572962. JD395249 - Sequence 376273 from Patent EP1572962. JD043236 - Sequence 24260 from Patent EP1572962. JD173550 - Sequence 154574 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_tob1Pathway - Role of Tob in T-cell activation h_il2Pathway - IL 2 signaling pathway h_il2rbPathway - IL-2 Receptor Beta Chain in T cell Activation h_th1th2Pathway - Th1/Th2 Differentiation
Reactome (by CSHL, EBI, and GO)
Protein P01589 (Reactome details) participates in the following event(s):
R-HSA-450054 Interleukin-2 receptor alpha binds interleukin-2 R-HSA-452091 Phosphorylation of IL2RB Y338 enables SHC recruitment R-HSA-452108 Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment R-HSA-452122 JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB R-HSA-919404 Phosphorylated STAT5 is released R-HSA-450027 Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta R-HSA-452100 SHC1 bound to IL2 receptor is phosphorylated R-HSA-452097 Recruited STAT5 is phosphorylated R-HSA-450063 Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit R-HSA-508292 SYK binds IL2RB R-HSA-451942 Within the IL-2R complex JAK3 phosphorylates JAK1 R-HSA-453111 Phosphorylated SHC recruits GRB2:SOS1 R-HSA-913374 Phosphorylated SHC1 recruits SHIP R-HSA-508282 SYK is a substrate for JAK1 R-HSA-508247 Gab2 binds the p85 subunit of Class 1A PI3 kinases R-HSA-913424 The SHC1:SHIP1 complex is stabilized by GRB2 R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange R-HSA-9020558 Interleukin-2 signaling R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-451927 Interleukin-2 family signaling R-HSA-8878171 Transcriptional regulation by RUNX1 R-HSA-449147 Signaling by Interleukins R-HSA-212436 Generic Transcription Pathway R-HSA-912526 Interleukin receptor SHC signaling R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-73857 RNA Polymerase II Transcription R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-168256 Immune System R-HSA-74160 Gene expression (Transcription) R-HSA-5673001 RAF/MAP kinase cascade R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-5683057 MAPK family signaling cascades R-HSA-162582 Signal Transduction
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
