Human Gene IL2RB (ENST00000216223.10_12) from GENCODE V47lift37
  Description: interleukin 2 receptor subunit beta, transcript variant 1 (from RefSeq NM_000878.5)
Gencode Transcript: ENST00000216223.10_12
Gencode Gene: ENSG00000100385.15_14
Transcript (Including UTRs)
   Position: hg19 chr22:37,521,883-37,545,956 Size: 24,074 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr22:37,524,136-37,540,212 Size: 16,077 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:37,521,883-37,545,956)mRNA (may differ from genome)Protein (551 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: IL2RB_HUMAN
DESCRIPTION: RecName: Full=Interleukin-2 receptor subunit beta; Short=IL-2 receptor subunit beta; Short=IL-2R subunit beta; Short=IL-2RB; AltName: Full=High affinity IL-2 receptor subunit beta; AltName: Full=p70-75; Short=p75; AltName: CD_antigen=CD122; Flags: Precursor;
FUNCTION: Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.
SUBUNIT: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding.
DOMAIN: The box 1 motif is required for JAK interaction and/or activation.
SIMILARITY: Belongs to the type I cytokine receptor family. Type 4 subfamily.
SIMILARITY: Contains 1 fibronectin type-III domain.
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il2rb/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: IL2RB
Diseases sorted by gene-association score: oligoarticular juvenile idiopathic arthritis* (11), rheumatoid factor-negative juvenile idiopathic arthritis* (11), diphtheria (7), virus associated hemophagocytic syndrome (3), heart tumor (3), intravascular large b-cell lymphoma (3), herpes simplex encephalitis (3), primary immunodeficiency disease (2), hemophagocytic lymphohistiocytosis (1), malaria (1), b-cell expansion with nfkb and t-cell anergy (1), rheumatoid arthritis, systemic juvenile (1), lymphoma, non-hodgkin (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 56.70 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 125.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -46.80125-0.374 Picture PostScript Text
3' UTR -794.002253-0.352 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003961 - Fibronectin_type3
IPR003531 - Hempt_rcpt_S_F1_CS
IPR013783 - Ig-like_fold

Pfam Domains:
PF18707 - Interleukin-2 receptor subunit beta N-terminal domain 1

SCOP Domains:
49265 - Fibronectin type III

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1ILM - Model 1ILN - Model 2B5I - X-ray MuPIT 2ERJ - X-ray MuPIT 3QAZ - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P14784
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004896 cytokine receptor activity
GO:0004911 interleukin-2 receptor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0019976 interleukin-2 binding

Biological Process:
GO:0000165 MAPK cascade
GO:0007165 signal transduction
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
GO:0035723 interleukin-15-mediated signaling pathway
GO:0038110 interleukin-2-mediated signaling pathway
GO:0043066 negative regulation of apoptotic process
GO:0065003 macromolecular complex assembly

Cellular Component:
GO:0005768 endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LP895138 - Sequence 2 from Patent EP3253886.
JD045798 - Sequence 26822 from Patent EP1572962.
A07795 - H.sapiens IL-2R-beta mRNA for interleukin-2 receptor beta-chain.
A07799 - H.sapiens IL-2R-beta mRNA for interleukin-2 beta-chain.
A07801 - H.sapiens IL-2R-beta mRNA for interleukin-2 beta-chain.
A28489 - H.sapiens mRNA for IL-2R-beta-chain from patent EP0395853.
M26062 - Human interleukin 2 receptor beta chain (p70-75) mRNA, complete cds.
BC025691 - Homo sapiens interleukin 2 receptor, beta, mRNA (cDNA clone MGC:34584 IMAGE:5207833), complete cds.
JD539111 - Sequence 520135 from Patent EP1572962.
JD220959 - Sequence 201983 from Patent EP1572962.
JD101151 - Sequence 82175 from Patent EP1572962.
JD049657 - Sequence 30681 from Patent EP1572962.
JD205572 - Sequence 186596 from Patent EP1572962.
JD341692 - Sequence 322716 from Patent EP1572962.
JD114837 - Sequence 95861 from Patent EP1572962.
JD133846 - Sequence 114870 from Patent EP1572962.
JD156003 - Sequence 137027 from Patent EP1572962.
JD131819 - Sequence 112843 from Patent EP1572962.
JD192320 - Sequence 173344 from Patent EP1572962.
JD099728 - Sequence 80752 from Patent EP1572962.
JD117489 - Sequence 98513 from Patent EP1572962.
JD054844 - Sequence 35868 from Patent EP1572962.
JD398841 - Sequence 379865 from Patent EP1572962.
JD250382 - Sequence 231406 from Patent EP1572962.
JD316304 - Sequence 297328 from Patent EP1572962.
JD343030 - Sequence 324054 from Patent EP1572962.
JD535611 - Sequence 516635 from Patent EP1572962.
LF210347 - JP 2014500723-A/17850: Polycomb-Associated Non-Coding RNAs.
JD158207 - Sequence 139231 from Patent EP1572962.
JD191101 - Sequence 172125 from Patent EP1572962.
JD276985 - Sequence 258009 from Patent EP1572962.
JD156979 - Sequence 138003 from Patent EP1572962.
JD199809 - Sequence 180833 from Patent EP1572962.
JD554524 - Sequence 535548 from Patent EP1572962.
JD086861 - Sequence 67885 from Patent EP1572962.
JD304146 - Sequence 285170 from Patent EP1572962.
JD448698 - Sequence 429722 from Patent EP1572962.
JD240696 - Sequence 221720 from Patent EP1572962.
JD137019 - Sequence 118043 from Patent EP1572962.
JD042025 - Sequence 23049 from Patent EP1572962.
JD197544 - Sequence 178568 from Patent EP1572962.
JD381830 - Sequence 362854 from Patent EP1572962.
JD270992 - Sequence 252016 from Patent EP1572962.
JD252203 - Sequence 233227 from Patent EP1572962.
JD519873 - Sequence 500897 from Patent EP1572962.
JD517159 - Sequence 498183 from Patent EP1572962.
JD454728 - Sequence 435752 from Patent EP1572962.
JD468314 - Sequence 449338 from Patent EP1572962.
JD516654 - Sequence 497678 from Patent EP1572962.
JD379332 - Sequence 360356 from Patent EP1572962.
JD316425 - Sequence 297449 from Patent EP1572962.
JD338989 - Sequence 320013 from Patent EP1572962.
JD521341 - Sequence 502365 from Patent EP1572962.
CR456506 - Homo sapiens IL2RB full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.IL2RB.V7).
JD498312 - Sequence 479336 from Patent EP1572962.
JD209587 - Sequence 190611 from Patent EP1572962.
JD503428 - Sequence 484452 from Patent EP1572962.
JD492618 - Sequence 473642 from Patent EP1572962.
CU013104 - Homo sapiens IL2RB, mRNA (cDNA clone IMAGE:100000363), complete cds, with stop codon, in Gateway system.
AK312860 - Homo sapiens cDNA, FLJ93303, Homo sapiens interleukin 2 receptor, beta (IL2RB), mRNA.
KJ897044 - Synthetic construct Homo sapiens clone ccsbBroadEn_06438 IL2RB gene, encodes complete protein.
DQ894099 - Synthetic construct Homo sapiens clone IMAGE:100008559; FLH167696.01L; RZPDo839E0189D interleukin 2 receptor, beta (IL2RB) gene, encodes complete protein.
AB463078 - Synthetic construct DNA, clone: pF1KB3336, Homo sapiens IL2RB gene for interleukin 2 receptor, beta, without stop codon, in Flexi system.
CU013392 - Homo sapiens IL2RB, mRNA (cDNA clone IMAGE:100000267), complete cds, without stop codon, in Gateway system.
JD112729 - Sequence 93753 from Patent EP1572962.
JD057982 - Sequence 39006 from Patent EP1572962.
JD065243 - Sequence 46267 from Patent EP1572962.
MA445924 - JP 2018138019-A/17850: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_il2Pathway - IL 2 signaling pathway
h_il2rbPathway - IL-2 Receptor Beta Chain in T cell Activation

Reactome (by CSHL, EBI, and GO)

Protein P14784 (Reactome details) participates in the following event(s):

R-HSA-451900 IL2RB binds JAK1
R-HSA-450027 Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta
R-HSA-452091 Phosphorylation of IL2RB Y338 enables SHC recruitment
R-HSA-452108 Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment
R-HSA-452122 JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB
R-HSA-919404 Phosphorylated STAT5 is released
R-HSA-450063 Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit
R-HSA-452100 SHC1 bound to IL2 receptor is phosphorylated
R-HSA-452097 Recruited STAT5 is phosphorylated
R-HSA-8983394 IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2
R-HSA-451942 Within the IL-2R complex JAK3 phosphorylates JAK1
R-HSA-453111 Phosphorylated SHC recruits GRB2:SOS1
R-HSA-913374 Phosphorylated SHC1 recruits SHIP
R-HSA-508292 SYK binds IL2RB
R-HSA-508247 Gab2 binds the p85 subunit of Class 1A PI3 kinases
R-HSA-913424 The SHC1:SHIP1 complex is stabilized by GRB2
R-HSA-508282 SYK is a substrate for JAK1
R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange
R-HSA-9020558 Interleukin-2 signaling
R-HSA-8983432 Interleukin-15 signaling
R-HSA-451927 Interleukin-2 family signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-912526 Interleukin receptor SHC signaling
R-HSA-168256 Immune System
R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-5683057 MAPK family signaling cascades
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B2R765, ENST00000216223.1, ENST00000216223.2, ENST00000216223.3, ENST00000216223.4, ENST00000216223.5, ENST00000216223.6, ENST00000216223.7, ENST00000216223.8, ENST00000216223.9, IL15RB , IL2RB , IL2RB_HUMAN, NM_000878, P14784, uc317cpi.1, uc317cpi.2
UCSC ID: ENST00000216223.10_12
RefSeq Accession: NM_000878.5
Protein: P14784 (aka IL2RB_HUMAN or IL2B_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.