ID:IL33_HUMAN DESCRIPTION: RecName: Full=Interleukin-33; Short=IL-33; AltName: Full=Interleukin-1 family member 11; Short=IL-1F11; AltName: Full=Nuclear factor from high endothelial venules; Short=NF-HEV; Flags: Precursor; FUNCTION: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. INTERACTION: Q01638:IL1RL1; NbExp=2; IntAct=EBI-724057, EBI-993762; SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta. PTM: Proteolytically converted to a mature form by CASP1 in vitro and calpains in vivo. SIMILARITY: Belongs to the IL-1 family. Highly divergent. CAUTION: Was originally (PubMed:12819012) thought to one of the key factors that controls the specialized post-capillary high endothelial venules (HEV) phenotype found in organized secondary lymphoid tissue and to be nuclear localized.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95760
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002281 macrophage activation involved in immune response GO:0002282 microglial cell activation involved in immune response GO:0002686 negative regulation of leukocyte migration GO:0002826 negative regulation of T-helper 1 type immune response GO:0002830 positive regulation of type 2 immune response GO:0006351 transcription, DNA-templated GO:0010469 regulation of receptor activity GO:0010628 positive regulation of gene expression GO:0016579 protein deubiquitination GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032689 negative regulation of interferon-gamma production GO:0032736 positive regulation of interleukin-13 production GO:0032753 positive regulation of interleukin-4 production GO:0032754 positive regulation of interleukin-5 production GO:0032755 positive regulation of interleukin-6 production GO:0038172 interleukin-33-mediated signaling pathway GO:0042092 type 2 immune response GO:0043032 positive regulation of macrophage activation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0050729 positive regulation of inflammatory response GO:0051024 positive regulation of immunoglobulin secretion GO:0051025 negative regulation of immunoglobulin secretion GO:0051607 defense response to virus GO:0061518 microglial cell proliferation GO:0090197 positive regulation of chemokine secretion GO:0097191 extrinsic apoptotic signaling pathway
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
