ID:IL4_HUMAN DESCRIPTION: RecName: Full=Interleukin-4; Short=IL-4; AltName: Full=B-cell stimulatory factor 1; Short=BSF-1; AltName: Full=Binetrakin; AltName: Full=Lymphocyte stimulatory factor 1; AltName: Full=Pitrakinra; Flags: Precursor; FUNCTION: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. INTERACTION: P78552:IL13RA1; NbExp=3; IntAct=EBI-367025, EBI-1391535; P24394:IL4R; NbExp=5; IntAct=EBI-367025, EBI-367009; SUBCELLULAR LOCATION: Secreted. DISEASE: Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. SIMILARITY: Belongs to the IL-4/IL-13 family. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il4/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P05112
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006955 immune response GO:0008203 cholesterol metabolic process GO:0010469 regulation of receptor activity GO:0010633 negative regulation of epithelial cell migration GO:0019221 cytokine-mediated signaling pathway GO:0030183 B cell differentiation GO:0030890 positive regulation of B cell proliferation GO:0032736 positive regulation of interleukin-13 production GO:0035745 T-helper 2 cell cytokine production GO:0042092 type 2 immune response GO:0042102 positive regulation of T cell proliferation GO:0042110 T cell activation GO:0042113 B cell activation GO:0042325 regulation of phosphorylation GO:0043011 myeloid dendritic cell differentiation GO:0043066 negative regulation of apoptotic process GO:0045189 connective tissue growth factor biosynthetic process GO:0045191 regulation of isotype switching GO:0045348 positive regulation of MHC class II biosynthetic process GO:0045582 positive regulation of T cell differentiation GO:0045671 negative regulation of osteoclast differentiation GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048295 positive regulation of isotype switching to IgE isotypes GO:0048304 positive regulation of isotype switching to IgG isotypes GO:0050776 regulation of immune response GO:0097028 dendritic cell differentiation GO:1903660 negative regulation of complement-dependent cytotoxicity GO:2000352 negative regulation of endothelial cell apoptotic process
Cellular Component: GO:0005576 extracellular region GO:0005615 extracellular space
Descriptions from all associated GenBank mRNAs
BC066277 - Homo sapiens interleukin 4, transcript variant 1, mRNA (cDNA clone MGC:79402 IMAGE:6971779), complete cds. BC066278 - Homo sapiens interleukin 4, mRNA (cDNA clone IMAGE:6971781). BC067514 - Homo sapiens interleukin 4, mRNA (cDNA clone MGC:79403 IMAGE:6971780), complete cds. BC067515 - Homo sapiens interleukin 4, transcript variant 1, mRNA (cDNA clone MGC:79405 IMAGE:6971782), complete cds. DD462529 - A METHOD FOR DESIGNING FLUORESCENCE RESONANT ENERGY TRANSFER PROBES. BC070123 - Homo sapiens interleukin 4, mRNA (cDNA clone MGC:88101 IMAGE:30415895), complete cds. M13982 - Human interleukin 4 (IL-4) mRNA, complete cds. E02167 - cDNA encoding human TL-4. JD307722 - Sequence 288746 from Patent EP1572962. AM937235 - Homo sapiens mRNA for interleukin 4 (IL4 gene), clone 4m. JD113966 - Sequence 94990 from Patent EP1572962. CU688314 - Synthetic construct Homo sapiens gateway clone IMAGE:100022920 5' read IL4 mRNA. KJ891455 - Synthetic construct Homo sapiens clone ccsbBroadEn_00849 IL4 gene, encodes complete protein. AB102862 - Homo sapiens IL4 mRNA for interleukin4 nirs variant1, complete cds. JX878389 - Homo sapiens interleukin 4 variant 2 (IL4) mRNA, complete cds, alternatively spliced. X81851 - H. sapiens IL-4 gene splice variant. AF043336 - Homo sapiens interleukin 4 delta 2 (IL4) mRNA, partial cds. FU768462 - Short interference ribonucleic acids for treating allergic diseases. EF173851 - Homo sapiens interleukin 4 mRNA, partial cds. FU768460 - Short interference ribonucleic acids for treating allergic diseases. FU768461 - Short interference ribonucleic acids for treating allergic diseases. AX934309 - Sequence 8 from Patent WO03087815. DD251153 - Compound Screening.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_cytokinePathway - Cytokine Network h_dcPathway - Dendritic cells in regulating TH1 and TH2 Development h_inflamPathway - Cytokines and Inflammatory Response h_stemPathway - Regulation of hematopoiesis by cytokines h_41bbPathway - The 4-1BB-dependent immune response h_GATA3pathway - GATA3 participate in activating the Th2 cytokine genes expression h_il4Pathway - IL 4 signaling pathway h_il5Pathway - IL 5 Signaling Pathway h_nktPathway - Selective expression of chemokine receptors during T-cell polarization h_th1th2Pathway - Th1/Th2 Differentiation h_tob1Pathway - Role of Tob in T-cell activation h_asbcellPathway - Antigen Dependent B Cell Activation
Reactome (by CSHL, EBI, and GO)
Protein P05112 (Reactome details) participates in the following event(s):
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
