Human Gene IL6 (ENST00000258743.10_12) from GENCODE V47lift37
  Description: interleukin 6, transcript variant 1 (from RefSeq NM_000600.5)
Gencode Transcript: ENST00000258743.10_12
Gencode Gene: ENSG00000136244.12_16
Transcript (Including UTRs)
   Position: hg19 chr7:22,766,819-22,771,617 Size: 4,799 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr7:22,766,882-22,771,192 Size: 4,311 Coding Exon Count: 5 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:22,766,819-22,771,617)mRNA (may differ from genome)Protein (212 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: IL6
Diseases sorted by gene-association score: rheumatoid arthritis, systemic juvenile* (613), kaposi sarcoma* (603), intracranial hemorrhage in brain cerebrovascular malformations* (550), crohn disease-associated growth failure* (389), diabetes mellitus, insulin-dependent* (325), arthritis (42), plasmacytoma (41), euthyroid sick syndrome (30), polyclonal hypergammaglobulinemia (29), mesangial proliferative glomerulonephritis (29), castleman disease (28), mouth disease (25), rheumatoid arthritis (25), chorioamnionitis (24), funisitis (24), monoclonal gammopathy of uncertain significance (24), acute cystitis (23), peritonitis (22), radiculopathy (22), poems syndrome (22), acute cholangitis (21), multicentric castleman disease (19), scorpion envenomation (19), angioimmunoblastic lymphadenopathy with dysproteinemia (18), streptococcal toxic-shock syndrome (18), cervical incompetence (18), adult-onset still's disease (18), joint disorders (17), periodontal disease (17), paraneoplastic syndromes (17), appendicitis (16), toxic shock syndrome (16), myelitis (16), cysticercosis (15), denture stomatitis (15), acute pancreatitis (15), trypanosomiasis (14), thrombocytosis (14), complex regional pain syndrome (14), burning mouth syndrome (13), angina pectoris (13), pneumonia (13), hemorrhagic fever with renal syndrome (13), nephropathia epidemica (13), endometritis (13), critical limb ischemia (13), viral pneumonia (13), stachybotrys chartarum (13), anterior uveitis (13), vibrio vulnificus infection (13), viral encephalitis (13), sleep apnea (13), inflammatory bowel disease (13), leukomalacia (13), necrotizing fasciitis (12), mycobacterium avium complex disease (12), dry eye syndrome (12), periodontitis (12), neuromyelitis optica (12), pyelonephritis (12), spinal cord injury (12), chagas disease (12), periventricular leukomalacia (12), nervous system disease (11), synovitis (11), diabetic macular edema (11), meconium aspiration syndrome (11), hand, foot and mouth disease (11), ileitis (11), fatty liver disease (11), osteoporotic fracture (11), aggressive periodontitis (11), acute pyelonephritis (11), localized scleroderma (11), gastroschisis (11), transverse myelitis (11), adult respiratory distress syndrome (10), endometriosis (10), lymphocytic choriomeningitis (10), cold agglutinin disease (10), recurrent corneal erosion (10), aphthous stomatitis (10), acute adrenal insufficiency (10), pneumoconiosis (10), bacteriuria (10), meningoencephalitis (10), osteoporosis (10), arteriosclerosis obliterans (10), takayasu arteritis (10), bacterial vaginosis (10), obstructive sleep apnea (10), extrinsic allergic alveolitis (10), viral meningitis (10), chikungunya (10), limb ischemia (9), connective tissue disease (9), mastitis (9), multiple myeloma (9), typhoid fever (9), gastroenteritis (9), preterm premature rupture of the membranes (9), retinal vein occlusion (9), post-thrombotic syndrome (9), prostatitis (9), cystitis (9), deficiency anemia (9), pericarditis (9), dengue shock syndrome (9), bullous impetigo (9), pulpitis (9), sleeping sickness (9), crimean-congo hemorrhagic fever (9), infective endocarditis (9), obstructive jaundice (9), monocytic leukemia (9), interstitial cystitis (9), laryngitis (9), capillary leak syndrome (9), central retinal vein occlusion (9), acquired immunodeficiency syndrome (9), aortic disease (9), peripheral artery disease (9), subacute thyroiditis (9), autoinflammation, lipodystrophy, and dermatosis syndrome (9), relapsing polychondritis (9), papillary conjunctivitis (9), acute respiratory distress syndrome (9), neutrophilia, hereditary (8), inguinal hernia (8), coronary stenosis (8), chronic fatigue syndrome (8), sudden sensorineural hearing loss (8), human herpesvirus 8 (8), arteriovenous fistula (8), nodular goiter (8), tropical spastic paraparesis (8), cyclic vomiting syndrome (8), lyme disease (8), systolic heart failure (8), diabetes mellitus, noninsulin-dependent (8), cerebral palsy (8), intussusception (8), keratitis (8), end stage renal failure (8), c1q deficiency (8), endocarditis (8), gingivitis (8), polyarteritis nodosa (8), brucellosis (8), uterine disease (8), traumatic brain injury (8), pericardial effusion (8), intermediate uveitis (8), fasciitis (8), anca-associated vasculitis (7), plasmodium vivax malaria (7), acute transverse myelitis (7), cryopyrin-associated periodic syndrome (7), macroglobulinemia (7), cardiogenic shock (7), rasmussen encephalitis (7), conjunctivitis (7), bone cancer (7), osteomyelitis (7), dengue hemorrhagic fever (7), protein-energy malnutrition (7), melioidosis (7), glossitis (7), impetigo (7), spondyloarthropathy (7), pertussis (7), acute vascular insufficiency of intestine (7), mixed connective tissue disease (7), bronchiolitis obliterans (7), rosacea (7), posterior urethral valves (7), meningitis (7), extramedullary plasmacytoma (7), retinitis pigmentosa 55 (7), bone inflammation disease (7), mixed lacrimal gland cancer (7), proliferative glomerulonephritis (7), reactive arthritis (7), eye lymphoma (7), cowpox (7), asbestosis (7), kawasaki disease (7), bagassosis (7), iron deficiency anemia (6), vaginal disease (6), otitis media (6), primary effusion lymphoma (6), hepatic encephalopathy (6), neonatal jaundice (6), alcoholic hepatitis (6), diastrophic dysplasia (6), intermittent claudication (6), arteriovenous malformation (6), temporal arteritis (6), adolescent idiopathic scoliosis (6), paracoccidioidomycosis (6), gingival overgrowth (6), echinococcosis (6), ischemic heart disease (6), null-cell leukemia (6), hemorrhagic fever (6), filariasis (6), central nervous system vasculitis (6), brain edema (6), post-transplant lymphoproliferative disease (6), uremic pruritus (6), chronic mucocutaneous candidiasis (6), acute monoblastic leukemia (6), esophagitis (6), leptospirosis (6), stromal keratitis (6), osteosclerotic myeloma (6), tonsillitis (6), intervertebral disc disease (6), brain injury (6), bronchiolitis (6), abdominal aortic aneurysm (6), toxoplasmosis (6), chlamydia (6), respiratory system disease (6), malaria (6), cholangitis (6), relapsing-remitting multiple sclerosis (6), retinal detachment (5), listeriosis (5), cecal disease (5), peripheral vascular disease (5), extrinsic cardiomyopathy (5), contact dermatitis (5), eye disease (5), encephalomalacia (5), lacrimal apparatus disease (5), idiopathic neutropenia (5), microscopic colitis (5), plasma cell neoplasm (5), placenta disease (5), perinatal necrotizing enterocolitis (5), eales disease (5), coronary artery disease (5), intestinal disease (5), osteoarthritis (5), hematopoietic stem cell transplantation (5), cytomegalovirus infection (5), hodgkin lymphoma (5), spondylitis (5), vaginitis (5), transient arthritis (5), prediabetes syndrome (5), acquired metabolic disease (5), hydrarthrosis (5), immune system disease (5), endometrial disease (5), myxoid liposarcoma (5), gingival disease (5), colitis (5), female reproductive system disease (4), commensal bacterial infectious disease (4), heart disease (4), macular retinal edema (4), breast carcinoma in situ (4), measles (4), intermediate coronary syndrome (4), bladder disease (4), human immunodeficiency virus infectious disease (4), mesenteric lymphadenitis (4), ulcerative colitis (4), overnutrition (4), photokeratitis (4), hepatocellular carcinoma (4), intermittent explosive disorder (4), liver disease (4), sudden infant death syndrome (4), keratoconjunctivitis sicca (4), multiple symmetrical lipomatosis (4), tuberculosis (4), louse-borne relapsing fever (4), pulmonary disease, chronic obstructive (4), systemic lupus erythematosus (4), lymph node disease (4), primary amebic meningoencephalitis (4), dilated cardiomyopathy (4), exanthem (4), astrocytoma (4), hypersensitivity reaction type ii disease (3), interstitial lung disease (3), arteriosclerosis (3), artery disease (3), aortic aneurysm (3), myocarditis (3), viral infectious disease (3), glucose intolerance (3), obesity (3), colorectal cancer (3), mood disorder (3), cerebrovascular disease (3), asthma (3), crohn's disease (3), pre-eclampsia (3), paget's disease of bone (3), leprosy (3), chronic kidney failure (3), hellp syndrome (2), focal epilepsy (2), wegener granulomatosis (2), esophageal cancer (2), multiple sclerosis, disease progression, modifier of (2), aplastic anemia (2), gastrointestinal system disease (2), pulmonary hypertension (2), common variable immunodeficiency (2), myocardial infarction (2), breast cancer (2), hypersensitivity reaction disease (2), urinary bladder cancer (2), glucose metabolism disease (2), pancreas disease (2), primary bacterial infectious disease (1), reproductive system disease (1), urinary system disease (1), sleep disorder (1), bone resorption disease (1), endometrial stromal sarcoma (1), parasitic protozoa infectious disease (1), macular degeneration, age-related, 1 (1), gastrointestinal system cancer (1), behcet syndrome (1), leukemia, acute myeloid (0)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.76 RPKM in Adipose - Visceral (Omentum)
Total median expression: 60.70 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.4063-0.244 Picture PostScript Text
3' UTR -79.60425-0.187 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009079 - 4_helix_cytokine-like_core
IPR012351 - 4_helix_cytokine_core
IPR003573 - IL6_MGF_GCSF
IPR003574 - Interleukin_6

Pfam Domains:
PF00489 - Interleukin-6/G-CSF/MGF family

SCOP Domains:
47266 - 4-helical cytokines

ModBase Predicted Comparative 3D Structure on Q75MH2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005125 cytokine activity
GO:0005138 interleukin-6 receptor binding

Biological Process:
GO:0006955 immune response
GO:0010469 regulation of receptor activity

Cellular Component:
GO:0005576 extracellular region


-  Descriptions from all associated GenBank mRNAs
  LQ882870 - Sequence 19 from Patent WO2018160841.
AK298077 - Homo sapiens cDNA FLJ52006 complete cds, moderately similar to Interleukin-6 precursor.
AK301141 - Homo sapiens cDNA FLJ61423 complete cds, highly similar to Interleukin-6 precursor.
A09363 - H.sapiens mRNA for interferon beta 2a.
X04430 - Human IFN-beta 2a mRNA for interferon-beta-2.
A09367 - Nucleotide sequence 5 from patent number EP0220574.
AK298013 - Homo sapiens cDNA FLJ55231 complete cds, highly similar to Interleukin-6 precursor.
M14584 - Human interleukin 6 mRNA, complete cds.
M18403 - Human hybridoma growth factor (interleukin 6) mRNA, complete cds.
BC015511 - Homo sapiens interleukin 6 (interferon, beta 2), mRNA (cDNA clone MGC:9215 IMAGE:3884652), complete cds.
M54894 - Human interleukin 6 mRNA, complete cds.
E03737 - cDNA encoding human B-cell differenciation factor.
M29150 - Human interleukin 6 (B-cell stimulatory factor-2) mRNA, complete cds.
E01518 - DNA encoding human B-cell differentiation factot.
E01537 - DNA encoding human B-cell differentiation factor.
E01616 - cDNA encoding human B cell differentiation factor.
E02030 - cDNA sequence coding for BSF-2.
E02202 - DNA encoding B cell differentiation factor (BSF-2).
E02930 - DNA sequence coding for human BCDF.
E11969 - cDNA encoding B-cell differentiation factor,BCDF.
X04602 - Human mRNA for interleukin BSF-2 (B-cell differentiation factor).
S56892 - interleukin-6 [human, tonsillar mononuclear cells, mRNA, 657 nt].
AB528399 - Synthetic construct DNA, clone: pF1KE1084, Homo sapiens IL6 gene for interleukin 6, without stop codon, in Flexi system.
CR450296 - Homo sapiens full open reading frame cDNA clone RZPDo834C041D for gene IL6, interleukin 6 (interferon, beta 2); complete cds; without stopcodon.
DQ894639 - Synthetic construct Homo sapiens clone IMAGE:100009099; FLH177151.01L; RZPDo839D08123D interleukin 6 (interferon, beta 2) (IL6) gene, encodes complete protein.
BT019748 - Homo sapiens interleukin 6 (interferon, beta 2) mRNA, complete cds.
BT019749 - Homo sapiens interleukin 6 (interferon, beta 2) mRNA, complete cds.
DQ891463 - Synthetic construct clone IMAGE:100004093; FLH177154.01X; RZPDo839D08124D interleukin 6 (interferon, beta 2) (IL6) gene, encodes complete protein.
JQ250825 - Homo sapiens interleukin 6 gene, complete cds.
E02205 - DNA encoding human B-cell differentiation factor (BSF-2).
X04403 - Human mRNA fragment for inducible 26 kDa protein (C-terminus) in fibroblasts.
JA113960 - Sequence 30 from Patent WO2011032100.
JD076900 - Sequence 57924 from Patent EP1572962.
JD093301 - Sequence 74325 from Patent EP1572962.
JD245113 - Sequence 226137 from Patent EP1572962.
MP584520 - Sequence 19 from Patent WO2020081767.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_erythPathway - Erythrocyte Differentiation Pathway
h_il10Pathway - IL-10 Anti-inflammatory Signaling Pathway
h_inflamPathway - Cytokines and Inflammatory Response
h_LairPathway - Cells and Molecules involved in local acute inflammatory response
h_cytokinePathway - Cytokine Network
h_her2Pathway - Role of ERBB2 in Signal Transduction and Oncology
h_il6Pathway - IL 6 signaling pathway
h_LDLpathway - Low-density lipoprotein (LDL) pathway during atherogenesis
h_il1rPathway - Signal transduction through IL1R
h_il5Pathway - IL 5 Signaling Pathway
h_il17Pathway - IL 17 Signaling Pathway
h_stemPathway - Regulation of hematopoiesis by cytokines

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000258743.1, ENST00000258743.2, ENST00000258743.3, ENST00000258743.4, ENST00000258743.5, ENST00000258743.6, ENST00000258743.7, ENST00000258743.8, ENST00000258743.9, hCG_38231 , IL6 , NM_000600, Q75MH2, Q75MH2_HUMAN, tcag7.131 , uc317gdx.1, uc317gdx.2
UCSC ID: ENST00000258743.10_12
RefSeq Accession: NM_000600.5
Protein: Q75MH2

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.