Human Gene IL9 (ENST00000274520.2_7) from GENCODE V47lift37
  Description: interleukin 9 (from RefSeq NM_000590.2)
Gencode Transcript: ENST00000274520.2_7
Gencode Gene: ENSG00000145839.2_9
Transcript (Including UTRs)
   Position: hg19 chr5:135,227,935-135,231,530 Size: 3,596 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr5:135,228,080-135,231,505 Size: 3,426 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:135,227,935-135,231,530)mRNA (may differ from genome)Protein (144 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: IL9_HUMAN
DESCRIPTION: RecName: Full=Interleukin-9; Short=IL-9; AltName: Full=Cytokine P40; AltName: Full=T-cell growth factor P40; Flags: Precursor;
FUNCTION: Supports IL-2 independent and IL-4 independent growth of helper T-cells.
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Belongs to the IL-7/IL-9 family.
WEB RESOURCE: Name=Wikipedia; Note=Interleukin-9 entry; URL="http://en.wikipedia.org/wiki/Interleukin_9";
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il9/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: IL9
Diseases sorted by gene-association score: trichuriasis (21), severe combined immunodeficiency, x-linked (20), asthma (12), cytokine deficiency (10), myelitis (9), enterobiasis (8), anaplastic large cell lymphoma (8), severe combined immunodeficiency (8), mast cell disease (8), severe combined immune deficiency (7), pompholyx (7), thymic dysplasia (7), jak3-deficient severe combined immunodeficiency (6), trichinosis (6), cystic fibrosis (3), atopy (3), allergic hypersensitivity disease (3), malaria (1), combined t cell and b cell immunodeficiency (1), bronchial disease (1), diamond-blackfan anemia (1), lymphoma, non-hodgkin (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.51 RPKM in Nerve - Tibial
Total median expression: 0.90 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -5.2025-0.208 Picture PostScript Text
3' UTR -15.20145-0.105 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018049 - Interleukin-7/-9_CS
IPR020447 - Interleukin-9
IPR000226 - Interleukin_7_9

ModBase Predicted Comparative 3D Structure on P15248
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005140 interleukin-9 receptor binding
GO:0008083 growth factor activity

Biological Process:
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0008284 positive regulation of cell proliferation
GO:0010469 regulation of receptor activity
GO:0030307 positive regulation of cell growth
GO:0038113 interleukin-9-mediated signaling pathway
GO:0045407 positive regulation of interleukin-5 biosynthetic process

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space


-  Descriptions from all associated GenBank mRNAs
  M30134 - Human P40 protein mRNA, complete cds.
S63356 - homolog of mouse T cell and mast cell growth factor P40 [human, mRNA, 591 nt].
X17543 - H.sapiens hp40 gene for P40 cytokine.
JD315416 - Sequence 296440 from Patent EP1572962.
JD357392 - Sequence 338416 from Patent EP1572962.
BC066283 - Homo sapiens interleukin 9, mRNA (cDNA clone MGC:79411 IMAGE:6971717), complete cds.
BC066284 - Homo sapiens interleukin 9, mRNA (cDNA clone MGC:79412 IMAGE:6971718), complete cds.
BC066285 - Homo sapiens interleukin 9, mRNA (cDNA clone MGC:79413 IMAGE:6971719), complete cds.
BC066286 - Homo sapiens interleukin 9, mRNA (cDNA clone MGC:79414 IMAGE:6971720), complete cds.
BC066287 - Homo sapiens interleukin 9, mRNA (cDNA clone MGC:79415 IMAGE:6971721), complete cds.
CU688130 - Synthetic construct Homo sapiens gateway clone IMAGE:100022892 5' read IL9 mRNA.
KJ891461 - Synthetic construct Homo sapiens clone ccsbBroadEn_00855 IL9 gene, encodes complete protein.
KR711432 - Synthetic construct Homo sapiens clone CCSBHm_00023537 IL9 (IL9) mRNA, encodes complete protein.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_stemPathway - Regulation of hematopoiesis by cytokines
h_cytokinePathway - Cytokine Network
h_erythPathway - Erythrocyte Differentiation Pathway

Reactome (by CSHL, EBI, and GO)

Protein P15248 (Reactome details) participates in the following event(s):

R-HSA-8963734 IL9 binds IL9R:JAK1 and IL2RG:JAK3
R-HSA-8985947 Interleukin-9 signaling
R-HSA-451927 Interleukin-2 family signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000274520.1, IL9_HUMAN, NM_000590, P15248, uc317jfk.1, uc317jfk.2
UCSC ID: ENST00000274520.2_7
RefSeq Accession: NM_000590.2
Protein: P15248 (aka IL9_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.