Human Gene ILK (ENST00000299421.9_5) from GENCODE V47lift37
  Description: integrin linked kinase, transcript variant 1 (from RefSeq NM_004517.4)
Gencode Transcript: ENST00000299421.9_5
Gencode Gene: ENSG00000166333.14_8
Transcript (Including UTRs)
   Position: hg19 chr11:6,625,004-6,632,101 Size: 7,098 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg19 chr11:6,625,502-6,631,842 Size: 6,341 Coding Exon Count: 12 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:6,625,004-6,632,101)mRNA (may differ from genome)Protein (452 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ILK
Diseases sorted by gene-association score: scar contracture (13), focal segmental glomerulosclerosis (4), lung cancer (2), ovarian cancer, somatic (2), stomach cancer (2), dilated cardiomyopathy (1), prostate cancer (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 162.72 RPKM in Colon - Sigmoid
Total median expression: 2608.53 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -59.10141-0.419 Picture PostScript Text
3' UTR -88.50259-0.342 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Descriptions from all associated GenBank mRNAs
  LF207829 - JP 2014500723-A/15332: Polycomb-Associated Non-Coding RNAs.
LF207831 - JP 2014500723-A/15334: Polycomb-Associated Non-Coding RNAs.
AK293474 - Homo sapiens cDNA FLJ53825 complete cds, highly similar to Integrin-linked protein kinase 1 (EC 2.7.11.1).
AK314843 - Homo sapiens cDNA, FLJ95734.
U40282 - Homo sapiens integrin-linked kinase (ILK) mRNA, complete cds.
AK296628 - Homo sapiens cDNA FLJ50979 complete cds, moderately similar to Integrin-linked protein kinase (EC 2.7.11.1).
BC001554 - Homo sapiens integrin-linked kinase, mRNA (cDNA clone MGC:5051 IMAGE:3457801), complete cds.
AB209416 - Homo sapiens mRNA for integrin-linked kinase variant protein.
CR749220 - Homo sapiens mRNA; cDNA DKFZp686F1765 (from clone DKFZp686F1765).
EU794625 - Homo sapiens epididymis secretory protein Li 28 (HEL-S-28) mRNA, complete cds.
JD038744 - Sequence 19768 from Patent EP1572962.
JD555098 - Sequence 536122 from Patent EP1572962.
KJ897056 - Synthetic construct Homo sapiens clone ccsbBroadEn_06450 ILK gene, encodes complete protein.
KJ905216 - Synthetic construct Homo sapiens clone ccsbBroadEn_14673 ILK gene, encodes complete protein.
KR709573 - Synthetic construct Homo sapiens clone CCSBHm_00003606 ILK (ILK) mRNA, encodes complete protein.
CU674762 - Synthetic construct Homo sapiens gateway clone IMAGE:100019468 5' read ILK mRNA.
AB463785 - Synthetic construct DNA, clone: pF1KB8187, Homo sapiens ILK gene for integrin-linked kinase, without stop codon, in Flexi system.
CR407673 - Homo sapiens full open reading frame cDNA clone RZPDo834B113D for gene ILK, integrin-linked kinase complete cds, without stopcodon.
DQ891172 - Synthetic construct clone IMAGE:100003802; FLH178834.01X; RZPDo839H08128D integrin-linked kinase (ILK) gene, encodes complete protein.
DQ894355 - Synthetic construct Homo sapiens clone IMAGE:100008815; FLH178830.01L; RZPDo839H08127D integrin-linked kinase (ILK) gene, encodes complete protein.
LF369387 - JP 2014500723-A/176890: Polycomb-Associated Non-Coding RNAs.
JD158576 - Sequence 139600 from Patent EP1572962.
LF369392 - JP 2014500723-A/176895: Polycomb-Associated Non-Coding RNAs.
JD521671 - Sequence 502695 from Patent EP1572962.
JD060336 - Sequence 41360 from Patent EP1572962.
JD293820 - Sequence 274844 from Patent EP1572962.
JD527351 - Sequence 508375 from Patent EP1572962.
JD518710 - Sequence 499734 from Patent EP1572962.
JD384971 - Sequence 365995 from Patent EP1572962.
LF369393 - JP 2014500723-A/176896: Polycomb-Associated Non-Coding RNAs.
JD445947 - Sequence 426971 from Patent EP1572962.
MA604964 - JP 2018138019-A/176890: Polycomb-Associated Non-Coding RNAs.
MA604969 - JP 2018138019-A/176895: Polycomb-Associated Non-Coding RNAs.
MA604970 - JP 2018138019-A/176896: Polycomb-Associated Non-Coding RNAs.
MA443406 - JP 2018138019-A/15332: Polycomb-Associated Non-Coding RNAs.
MA443408 - JP 2018138019-A/15334: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_ptenPathway - PTEN dependent cell cycle arrest and apoptosis

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000299421.1, ENST00000299421.2, ENST00000299421.3, ENST00000299421.4, ENST00000299421.5, ENST00000299421.6, ENST00000299421.7, ENST00000299421.8, HEL-S-28 , NM_004517, uc317mjo.1, uc317mjo.2, V9HWF0, V9HWF0_HUMAN
UCSC ID: ENST00000299421.9_5
RefSeq Accession: NM_004517.4

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.