ID:ING5_HUMAN DESCRIPTION: RecName: Full=Inhibitor of growth protein 5; AltName: Full=p28ING5; FUNCTION: Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator. SUBUNIT: Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of PHF15, PHF16 and PHF17. Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts with EP300 and TP53. SUBCELLULAR LOCATION: Nucleus. DOMAIN: The PHD-type zinc finger mediates the binding to H3K4me3. SIMILARITY: Belongs to the ING family. SIMILARITY: Contains 1 PHD-type zinc finger.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8WYH8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006260 DNA replication GO:0006325 chromatin organization GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006473 protein acetylation GO:0008285 negative regulation of cell proliferation GO:0016573 histone acetylation GO:0043065 positive regulation of apoptotic process GO:0043966 histone H3 acetylation GO:0045893 positive regulation of transcription, DNA-templated GO:0045926 negative regulation of growth GO:1901796 regulation of signal transduction by p53 class mediator
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
