Human Gene IP6K3 (ENST00000293756.5_7) from GENCODE V47lift37
  Description: inositol hexakisphosphate kinase 3, transcript variant 1 (from RefSeq NM_054111.5)
Gencode Transcript: ENST00000293756.5_7
Gencode Gene: ENSG00000161896.12_9
Transcript (Including UTRs)
   Position: hg19 chr6:33,689,439-33,714,682 Size: 25,244 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr6:33,690,497-33,703,253 Size: 12,757 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:33,689,439-33,714,682)mRNA (may differ from genome)Protein (410 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: IP6K3_HUMAN
DESCRIPTION: RecName: Full=Inositol hexakisphosphate kinase 3; Short=InsP6 kinase 3; EC=2.7.4.21; AltName: Full=Inositol hexaphosphate kinase 3;
FUNCTION: Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.
CATALYTIC ACTIVITY: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
CATALYTIC ACTIVITY: ATP + 1D-myo-inositol 1,3,4,5,6- pentakisphosphate = ADP + 1D-myo-inositol diphosphate tetrakisphosphate (isomeric configuration unknown).
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Detected in brain.
SIMILARITY: Belongs to the inositol phosphokinase (IPK) family.
SEQUENCE CAUTION: Sequence=BAB71225.2; Type=Frameshift; Positions=122;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 105.64 RPKM in Muscle - Skeletal
Total median expression: 190.86 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -98.10327-0.300 Picture PostScript Text
3' UTR -332.701058-0.314 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005522 - IPK

Pfam Domains:
PF03770 - Inositol polyphosphate kinase

SCOP Domains:
56104 - SAICAR synthase-like

ModBase Predicted Comparative 3D Structure on Q96PC2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity
GO:0000828 inositol hexakisphosphate kinase activity
GO:0000829 inositol heptakisphosphate kinase activity
GO:0000831 inositol hexakisphosphate 6-kinase activity
GO:0000832 inositol hexakisphosphate 5-kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0052723 inositol hexakisphosphate 1-kinase activity
GO:0052724 inositol hexakisphosphate 3-kinase activity
GO:0052836 inositol 5-diphosphate pentakisphosphate 5-kinase activity
GO:0052839 inositol diphosphate tetrakisphosphate kinase activity

Biological Process:
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation
GO:0032958 inositol phosphate biosynthetic process
GO:0043647 inositol phosphate metabolic process
GO:0046488 phosphatidylinositol metabolic process

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  BC089389 - Homo sapiens inositol hexakisphosphate kinase 3, mRNA (cDNA clone MGC:102928 IMAGE:30530548), complete cds.
AK056586 - Homo sapiens cDNA FLJ32024 fis, clone NTONG1000182, highly similar to Inositol hexaphosphate kinase 3 (EC 2.7.4.21).
AF393812 - Homo sapiens inositol hexakisphosphate kinase 3 mRNA, complete cds.
AK223572 - Homo sapiens mRNA for inositol hexaphosphate kinase 3 variant, clone: FCC129C10.
JD036647 - Sequence 17671 from Patent EP1572962.
JD265825 - Sequence 246849 from Patent EP1572962.
JD500269 - Sequence 481293 from Patent EP1572962.
JD565468 - Sequence 546492 from Patent EP1572962.
JD068018 - Sequence 49042 from Patent EP1572962.
JD251088 - Sequence 232112 from Patent EP1572962.
JD496030 - Sequence 477054 from Patent EP1572962.
AK289935 - Homo sapiens cDNA FLJ75297 complete cds, highly similar to Homo sapiens inositol hexakisphosphate kinase 3 mRNA.
JD509912 - Sequence 490936 from Patent EP1572962.
JD412215 - Sequence 393239 from Patent EP1572962.
KJ900054 - Synthetic construct Homo sapiens clone ccsbBroadEn_09448 IP6K3 gene, encodes complete protein.
JD064983 - Sequence 46007 from Patent EP1572962.
JD443341 - Sequence 424365 from Patent EP1572962.
JD317224 - Sequence 298248 from Patent EP1572962.
JD419708 - Sequence 400732 from Patent EP1572962.
JD133144 - Sequence 114168 from Patent EP1572962.
JD377333 - Sequence 358357 from Patent EP1572962.
JD228455 - Sequence 209479 from Patent EP1572962.
JD142642 - Sequence 123666 from Patent EP1572962.
JD402466 - Sequence 383490 from Patent EP1572962.
JD298174 - Sequence 279198 from Patent EP1572962.
JD234688 - Sequence 215712 from Patent EP1572962.
JD380474 - Sequence 361498 from Patent EP1572962.
JD063619 - Sequence 44643 from Patent EP1572962.
JD420839 - Sequence 401863 from Patent EP1572962.
JD223099 - Sequence 204123 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-6369 - inositol diphosphates biosynthesis
PWY-6371 - superpathway of inositol phosphate compounds

Reactome (by CSHL, EBI, and GO)

Protein Q96PC2 (Reactome details) participates in the following event(s):

R-HSA-1855227 IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol
R-HSA-1855223 I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol
R-HSA-1855193 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol
R-HSA-1855158 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol
R-HSA-1855194 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol
R-HSA-1855167 Synthesis of pyrophosphates in the cytosol
R-HSA-1483249 Inositol phosphate metabolism
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000293756.1, ENST00000293756.2, ENST00000293756.3, ENST00000293756.4, IHPK3, IP6K3_HUMAN, NM_054111, Q96MQ9, Q96PC2, uc317len.1, uc317len.2
UCSC ID: ENST00000293756.5_7
RefSeq Accession: NM_054111.5
Protein: Q96PC2 (aka IP6K3_HUMAN or IHK3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.