Human Gene IPMK (ENST00000373935.4_7) from GENCODE V47lift37
  Description: inositol polyphosphate multikinase (from RefSeq NM_152230.5)
Gencode Transcript: ENST00000373935.4_7
Gencode Gene: ENSG00000151151.6_10
Transcript (Including UTRs)
   Position: hg19 chr10:59,951,278-60,027,654 Size: 76,377 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr10:59,955,837-60,027,371 Size: 71,535 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:59,951,278-60,027,654)mRNA (may differ from genome)Protein (416 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: IPMK_HUMAN
DESCRIPTION: RecName: Full=Inositol polyphosphate multikinase; EC=2.7.1.151; AltName: Full=Inositol 1,3,4,6-tetrakisphosphate 5-kinase;
FUNCTION: Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4).
CATALYTIC ACTIVITY: 2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon.
SIMILARITY: Belongs to the inositol phosphokinase (IPK) family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: IPMK
Diseases sorted by gene-association score: hereditary neuroendocrine tumor of small intestine* (350)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.69 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 88.55 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -136.20283-0.481 Picture PostScript Text
3' UTR -958.204559-0.210 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005522 - IPK

Pfam Domains:
PF03770 - Inositol polyphosphate kinase

SCOP Domains:
56104 - SAICAR synthase-like

ModBase Predicted Comparative 3D Structure on Q8NFU5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0000823 inositol-1,4,5-trisphosphate 6-kinase activity
GO:0000824 inositol tetrakisphosphate 3-kinase activity
GO:0000825 inositol tetrakisphosphate 6-kinase activity
GO:0005524 ATP binding
GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0047326 inositol tetrakisphosphate 5-kinase activity

Biological Process:
GO:0016310 phosphorylation
GO:0032958 inositol phosphate biosynthetic process
GO:0043647 inositol phosphate metabolic process

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus


-  Descriptions from all associated GenBank mRNAs
  AK096839 - Homo sapiens cDNA FLJ39520 fis, clone PUAEN2001526, highly similar to Inositol polyphosphate multikinase (EC 2.7.1.151).
BC016612 - Homo sapiens cDNA clone IMAGE:4510867, containing frame-shift errors.
BC065709 - Homo sapiens inositol polyphosphate multikinase, mRNA (cDNA clone MGC:71901 IMAGE:6654071), complete cds.
AF432853 - Homo sapiens inositol polyphosphate multikinase (IPMK) mRNA, complete cds.
KJ905651 - Synthetic construct Homo sapiens clone ccsbBroadEn_15293 IPMK gene, encodes complete protein.
CU688082 - Synthetic construct Homo sapiens gateway clone IMAGE:100023119 5' read IPMK mRNA.
JD406783 - Sequence 387807 from Patent EP1572962.
JD459137 - Sequence 440161 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-6358 - superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
PWY-6362 - 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
PWY-6364 - D-myo-inositol (1,3,4)-trisphosphate biosynthesis
PWY-6365 - D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis
PWY-6366 - D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis
PWY-6369 - inositol diphosphates biosynthesis
PWY-6371 - superpathway of inositol phosphate compounds
PWY-6554 - 1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)

Reactome (by CSHL, EBI, and GO)

Protein Q8NFU5 (Reactome details) participates in the following event(s):

R-HSA-1855206 I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus
R-HSA-1855228 I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus
R-HSA-1855233 I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus
R-HSA-1855185 I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus
R-HSA-1855191 Synthesis of IPs in the nucleus
R-HSA-1483249 Inositol phosphate metabolism
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000373935.1, ENST00000373935.2, ENST00000373935.3, IMPK , IPMK_HUMAN, NM_152230, Q8NFU5, uc318lej.1, uc318lej.2
UCSC ID: ENST00000373935.4_7
RefSeq Accession: NM_152230.5
Protein: Q8NFU5 (aka IPMK_HUMAN)

-  Gene Model Information
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.