ID:IPO13_HUMAN DESCRIPTION: RecName: Full=Importin-13; Short=Imp13; AltName: Full=Karyopherin-13; Short=Kap13; AltName: Full=Ran-binding protein 13; Short=RanBP13; FUNCTION: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13. SUBUNIT: Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6. INTERACTION: Q15699:ALX1; NbExp=2; IntAct=EBI-747310, EBI-750671; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Expressed in fetal brain, heart, intestine and kidney. SIMILARITY: Belongs to the importin beta family. SIMILARITY: Contains 20 HEAT repeats. SIMILARITY: Contains 1 importin N-terminal domain. SEQUENCE CAUTION: Sequence=BAA34444.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB14575.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O94829
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
