Human Gene IQGAP3 (ENST00000361170.7_7) from GENCODE V47lift37
  Description: IQ motif containing GTPase activating protein 3 (from RefSeq NM_178229.5)
Gencode Transcript: ENST00000361170.7_7
Gencode Gene: ENSG00000183856.11_9
Transcript (Including UTRs)
   Position: hg19 chr1:156,495,197-156,542,357 Size: 47,161 Total Exon Count: 38 Strand: -
Coding Region
   Position: hg19 chr1:156,496,278-156,542,321 Size: 46,044 Coding Exon Count: 38 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:156,495,197-156,542,357)mRNA (may differ from genome)Protein (1631 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: IQGA3_HUMAN
DESCRIPTION: RecName: Full=Ras GTPase-activating-like protein IQGAP3;
SIMILARITY: Contains 1 CH (calponin-homology) domain.
SIMILARITY: Contains 4 IQ domains.
SIMILARITY: Contains 1 Ras-GAP domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.03 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 31.13 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -2.9036-0.081 Picture PostScript Text
3' UTR -334.701081-0.310 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001715 - CH-domain
IPR000048 - IQ_motif_EF-hand-BS
IPR001936 - RasGAP
IPR000593 - RasGAP_C
IPR023152 - RasGAP_CS
IPR008936 - Rho_GTPase_activation_prot
IPR001202 - WW_Rsp5_WWP

Pfam Domains:
PF00307 - Calponin homology (CH) domain
PF00612 - IQ calmodulin-binding motif
PF00616 - GTPase-activator protein for Ras-like GTPase
PF03836 - RasGAP C-terminus

SCOP Domains:
48350 - GTPase activation domain, GAP
47576 - Calponin-homology domain, CH-domain
51045 - WW domain
52540 - P-loop containing nucleoside triphosphate hydrolases
143885 - RGC domain-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3ISU - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q86VI3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details   Gene Details
Gene SorterGene Sorter   Gene Sorter
 RGDEnsembl  SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005516 calmodulin binding
GO:0017016 Ras GTPase binding
GO:0017048 Rho GTPase binding
GO:0070856 myosin VI light chain binding

Biological Process:
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000187 activation of MAPK activity
GO:0001934 positive regulation of protein phosphorylation
GO:0007165 signal transduction
GO:0007265 Ras protein signal transduction
GO:0008361 regulation of cell size
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0033601 positive regulation of mammary gland epithelial cell proliferation
GO:0043087 regulation of GTPase activity
GO:0070371 ERK1 and ERK2 cascade
GO:0071310 cellular response to organic substance

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005911 cell-cell junction
GO:0016328 lateral plasma membrane


-  Descriptions from all associated GenBank mRNAs
  AB105103 - Homo sapiens IQGAP3 mRNA, complete cds.
BC033549 - Homo sapiens cDNA clone IMAGE:4826963, containing frame-shift errors.
AK122653 - Homo sapiens cDNA FLJ16086 fis, clone NT2RP7005118, moderately similar to RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP1.
BC131536 - Homo sapiens IQ motif containing GTPase activating protein 3, mRNA (cDNA clone MGC:141847 IMAGE:40082932), complete cds.
AY253300 - Homo sapiens IQGAP3 (IQGAP3) mRNA, complete cds.
KJ900117 - Synthetic construct Homo sapiens clone ccsbBroadEn_09511 IQGAP3 gene, encodes complete protein.
JD315560 - Sequence 296584 from Patent EP1572962.
JD518429 - Sequence 499453 from Patent EP1572962.
JD195502 - Sequence 176526 from Patent EP1572962.
JD092703 - Sequence 73727 from Patent EP1572962.
JD444847 - Sequence 425871 from Patent EP1572962.
JD117786 - Sequence 98810 from Patent EP1572962.
JD058625 - Sequence 39649 from Patent EP1572962.
JD469321 - Sequence 450345 from Patent EP1572962.
JD274428 - Sequence 255452 from Patent EP1572962.
JD455888 - Sequence 436912 from Patent EP1572962.
JD313392 - Sequence 294416 from Patent EP1572962.
JD103915 - Sequence 84939 from Patent EP1572962.
JD400570 - Sequence 381594 from Patent EP1572962.
JD206901 - Sequence 187925 from Patent EP1572962.
JD495320 - Sequence 476344 from Patent EP1572962.
JD088786 - Sequence 69810 from Patent EP1572962.
JD273497 - Sequence 254521 from Patent EP1572962.
JD241217 - Sequence 222241 from Patent EP1572962.
JD548344 - Sequence 529368 from Patent EP1572962.
JD074778 - Sequence 55802 from Patent EP1572962.
JD174418 - Sequence 155442 from Patent EP1572962.
JD373951 - Sequence 354975 from Patent EP1572962.
JD455616 - Sequence 436640 from Patent EP1572962.
JD277487 - Sequence 258511 from Patent EP1572962.
JD434160 - Sequence 415184 from Patent EP1572962.
JD392682 - Sequence 373706 from Patent EP1572962.
JD526570 - Sequence 507594 from Patent EP1572962.
JD290913 - Sequence 271937 from Patent EP1572962.
JD385275 - Sequence 366299 from Patent EP1572962.
JD339934 - Sequence 320958 from Patent EP1572962.
JD471338 - Sequence 452362 from Patent EP1572962.
JD279380 - Sequence 260404 from Patent EP1572962.
JD102761 - Sequence 83785 from Patent EP1572962.
JD186034 - Sequence 167058 from Patent EP1572962.
JD439953 - Sequence 420977 from Patent EP1572962.
JD399882 - Sequence 380906 from Patent EP1572962.
JD043016 - Sequence 24040 from Patent EP1572962.
JD550168 - Sequence 531192 from Patent EP1572962.
JD210043 - Sequence 191067 from Patent EP1572962.
JD466075 - Sequence 447099 from Patent EP1572962.
JD525664 - Sequence 506688 from Patent EP1572962.
JD375177 - Sequence 356201 from Patent EP1572962.
JD088358 - Sequence 69382 from Patent EP1572962.
JD304665 - Sequence 285689 from Patent EP1572962.
JD168469 - Sequence 149493 from Patent EP1572962.
JD524900 - Sequence 505924 from Patent EP1572962.
JD328996 - Sequence 310020 from Patent EP1572962.
JD115247 - Sequence 96271 from Patent EP1572962.
JD168904 - Sequence 149928 from Patent EP1572962.
JD471127 - Sequence 452151 from Patent EP1572962.
JD400357 - Sequence 381381 from Patent EP1572962.
JD462865 - Sequence 443889 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q86VI3 (Reactome details) participates in the following event(s):

R-HSA-5626469 GTP-bound RAC1 and CDC42 bind IQGAPs
R-HSA-5626507 IQGAPs bind F-actin, which is inhibited by calmodulin
R-HSA-5626549 IQGAPs bind CALM1
R-HSA-5626467 RHO GTPases activate IQGAPs
R-HSA-195258 RHO GTPase Effectors
R-HSA-194315 Signaling by Rho GTPases
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000361170.1, ENST00000361170.2, ENST00000361170.3, ENST00000361170.4, ENST00000361170.5, ENST00000361170.6, IQGA3_HUMAN, NM_178229, Q5T3H8, Q86VI3, uc318bxi.1, uc318bxi.2
UCSC ID: ENST00000361170.7_7
RefSeq Accession: NM_178229.5
Protein: Q86VI3 (aka IQGA3_HUMAN or IQG3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.