Human Gene ITGA5 (ENST00000293379.9_7) from GENCODE V47lift37
  Description: integrin subunit alpha 5 (from RefSeq NM_002205.5)
Gencode Transcript: ENST00000293379.9_7
Gencode Gene: ENSG00000161638.11_10
Transcript (Including UTRs)
   Position: hg19 chr12:54,789,045-54,813,050 Size: 24,006 Total Exon Count: 30 Strand: -
Coding Region
   Position: hg19 chr12:54,790,077-54,812,982 Size: 22,906 Coding Exon Count: 30 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:54,789,045-54,813,050)mRNA (may differ from genome)Protein (1049 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCHuman Cortex Gene ExpressionMalacardsMGIOMIMPubMed
ReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ITA5_HUMAN
DESCRIPTION: RecName: Full=Integrin alpha-5; AltName: Full=CD49 antigen-like family member E; AltName: Full=Fibronectin receptor subunit alpha; AltName: Full=Integrin alpha-F; AltName: Full=VLA-5; AltName: CD_antigen=CD49e; Contains: RecName: Full=Integrin alpha-5 heavy chain; Contains: RecName: Full=Integrin alpha-5 light chain; Flags: Precursor;
FUNCTION: Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with RAB21 and COMP. Interacts with HIV- 1 Tat.
INTERACTION: Q9H0F6:SHARPIN; NbExp=4; IntAct=EBI-1382311, EBI-3942966;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
PTM: Proteolytic cleavage by PCSK5 mediates activation of the precursor.
SIMILARITY: Belongs to the integrin alpha chain family.
SIMILARITY: Contains 7 FG-GAP repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ITGA5
Diseases sorted by gene-association score: colon carcinoma in situ (9), retinitis pigmentosa 60 (9), congenital epulis (7), hiv-1 (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D013749 Tetrachlorodibenzodioxin
  • D015058 1-Naphthylisothiocyanate
  • D020122 tert-Butylhydroperoxide
  • C016403 2,4-dinitrotoluene
  • C023514 2,6-dinitrotoluene
  • C093973 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
  • C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
  • C426703 3-(3-(3-(4,5-dihydroimidazol-2-ylamino)propyloxylisoxazol-5-yl)carbonylamino)-2-(phenylsulfonylamino)propionic acid
  • C027576 4-hydroxy-2-nonenal
  • C012606 4-vinyl-1-cyclohexene dioxide
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 378.66 RPKM in Artery - Tibial
Total median expression: 2383.61 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -19.5068-0.287 Picture PostScript Text
3' UTR -378.201032-0.366 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013517 - FG-GAP
IPR013519 - Int_alpha_beta-p
IPR000413 - Integrin_alpha
IPR013649 - Integrin_alpha-2
IPR018184 - Integrin_alpha_C_CS

Pfam Domains:
PF01839 - FG-GAP repeat
PF08441 - Integrin alpha

SCOP Domains:
69179 - Integrin domains
69318 - Integrin alpha N-terminal domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3VI3 - X-ray MuPIT 3VI4 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P08648
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001618 virus receptor activity
GO:0005154 epidermal growth factor receptor binding
GO:0005161 platelet-derived growth factor receptor binding
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0043184 vascular endothelial growth factor receptor 2 binding
GO:0046872 metal ion binding
GO:0050839 cell adhesion molecule binding

Biological Process:
GO:0001525 angiogenesis
GO:0007044 cell-substrate junction assembly
GO:0007155 cell adhesion
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007159 leukocyte cell-cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007613 memory
GO:0010811 positive regulation of cell-substrate adhesion
GO:0016032 viral process
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031589 cell-substrate adhesion
GO:0033627 cell adhesion mediated by integrin
GO:0033631 cell-cell adhesion mediated by integrin
GO:0034113 heterotypic cell-cell adhesion
GO:0035313 wound healing, spreading of epidermal cells
GO:0035987 endodermal cell differentiation
GO:0045765 regulation of angiogenesis
GO:0046718 viral entry into host cell
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050900 leukocyte migration
GO:1903672 positive regulation of sprouting angiogenesis
GO:2000811 negative regulation of anoikis

Cellular Component:
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0031410 cytoplasmic vesicle
GO:0045202 synapse
GO:0071062 alphav-beta3 integrin-vitronectin complex
GO:0005911 cell-cell junction
GO:0032587 ruffle membrane


-  Descriptions from all associated GenBank mRNAs
  BX647780 - Homo sapiens mRNA; cDNA DKFZp686D0887 (from clone DKFZp686D0887).
X06256 - Human mRNA for integrin alpha 5 subunit.
M13918 - Homo sapiens fibronectin receptor alpha-subunit precursor (ITGA5) mRNA, partial cds.
LF210490 - JP 2014500723-A/17993: Polycomb-Associated Non-Coding RNAs.
LF214034 - JP 2014500723-A/21537: Polycomb-Associated Non-Coding RNAs.
BC008786 - Homo sapiens integrin, alpha 5 (fibronectin receptor, alpha polypeptide), mRNA (cDNA clone MGC:3697 IMAGE:3629647), complete cds.
LF338208 - JP 2014500723-A/145711: Polycomb-Associated Non-Coding RNAs.
JD259372 - Sequence 240396 from Patent EP1572962.
HW500562 - JP 2014045773-A/7: INHIBITORS OF MICRO-RNAs FOR USE FOR PREVENTING AND/OR ATTENUATING SKIN AGEING.
JC612225 - Sequence 7 from Patent EP2703498.
JD193766 - Sequence 174790 from Patent EP1572962.
JD159121 - Sequence 140145 from Patent EP1572962.
JD189987 - Sequence 171011 from Patent EP1572962.
JD208256 - Sequence 189280 from Patent EP1572962.
JD338930 - Sequence 319954 from Patent EP1572962.
JD055708 - Sequence 36732 from Patent EP1572962.
JD278187 - Sequence 259211 from Patent EP1572962.
JD274752 - Sequence 255776 from Patent EP1572962.
JD169143 - Sequence 150167 from Patent EP1572962.
JD094436 - Sequence 75460 from Patent EP1572962.
JD456844 - Sequence 437868 from Patent EP1572962.
JD332924 - Sequence 313948 from Patent EP1572962.
JD210065 - Sequence 191089 from Patent EP1572962.
LF338211 - JP 2014500723-A/145714: Polycomb-Associated Non-Coding RNAs.
JD439176 - Sequence 420200 from Patent EP1572962.
JD527667 - Sequence 508691 from Patent EP1572962.
JD463988 - Sequence 445012 from Patent EP1572962.
JD044333 - Sequence 25357 from Patent EP1572962.
JD085741 - Sequence 66765 from Patent EP1572962.
JD403971 - Sequence 384995 from Patent EP1572962.
LF338213 - JP 2014500723-A/145716: Polycomb-Associated Non-Coding RNAs.
JD307931 - Sequence 288955 from Patent EP1572962.
LF338215 - JP 2014500723-A/145718: Polycomb-Associated Non-Coding RNAs.
LQ665138 - Sequence 24 from Patent WO2016151287.
AK291570 - Homo sapiens cDNA FLJ77742 complete cds, highly similar to Homo sapiens integrin, alpha 5 (fibronectin receptor, alpha polypeptide), mRNA.
JD209535 - Sequence 190559 from Patent EP1572962.
JD057681 - Sequence 38705 from Patent EP1572962.
JD173561 - Sequence 154585 from Patent EP1572962.
JD530527 - Sequence 511551 from Patent EP1572962.
JD121219 - Sequence 102243 from Patent EP1572962.
JD415305 - Sequence 396329 from Patent EP1572962.
LF338216 - JP 2014500723-A/145719: Polycomb-Associated Non-Coding RNAs.
JD132991 - Sequence 114015 from Patent EP1572962.
AK312414 - Homo sapiens cDNA, FLJ92752, highly similar to Homo sapiens integrin, alpha 5 (fibronectin receptor, alphapolypeptide) (ITGA5), mRNA.
KJ891490 - Synthetic construct Homo sapiens clone ccsbBroadEn_00884 ITGA5 gene, encodes complete protein.
DQ892690 - Synthetic construct clone IMAGE:100005320; FLH188911.01X; RZPDo839H0573D integrin, alpha 5 (fibronectin receptor, alpha polypeptide) (ITGA5) gene, encodes complete protein.
EU176722 - Synthetic construct Homo sapiens clone IMAGE:100011505; FLH188910.01L; RZPDo839F07255D integrin, alpha 5 (fibronectin receptor, alpha polypeptide) (ITGA5) gene, encodes complete protein.
AB385038 - Synthetic construct DNA, clone: pF1KB5101, Homo sapiens ITGA5 gene for integrin alpha-5 precursor, complete cds, without stop codon, in Flexi system.
KY966270 - Homo sapiens cell line 95T1000 ITGA5/SLC9B1 fusion mRNA, partial sequence.
LF338219 - JP 2014500723-A/145722: Polycomb-Associated Non-Coding RNAs.
LF338220 - JP 2014500723-A/145723: Polycomb-Associated Non-Coding RNAs.
LF338222 - JP 2014500723-A/145725: Polycomb-Associated Non-Coding RNAs.
LF338223 - JP 2014500723-A/145726: Polycomb-Associated Non-Coding RNAs.
LF338224 - JP 2014500723-A/145727: Polycomb-Associated Non-Coding RNAs.
LF338226 - JP 2014500723-A/145729: Polycomb-Associated Non-Coding RNAs.
LF338227 - JP 2014500723-A/145730: Polycomb-Associated Non-Coding RNAs.
LF338228 - JP 2014500723-A/145731: Polycomb-Associated Non-Coding RNAs.
LF338230 - JP 2014500723-A/145733: Polycomb-Associated Non-Coding RNAs.
LF338231 - JP 2014500723-A/145734: Polycomb-Associated Non-Coding RNAs.
LF338232 - JP 2014500723-A/145735: Polycomb-Associated Non-Coding RNAs.
AK304696 - Homo sapiens cDNA FLJ50382 complete cds, moderately similar to Integrin alpha-5 precursor.
LF338234 - JP 2014500723-A/145737: Polycomb-Associated Non-Coding RNAs.
LF338235 - JP 2014500723-A/145738: Polycomb-Associated Non-Coding RNAs.
AK311051 - Homo sapiens cDNA, FLJ18093.
LF338237 - JP 2014500723-A/145740: Polycomb-Associated Non-Coding RNAs.
AY429549 - Homo sapiens ITGA5v_1 mRNA sequence; alternatively spliced.
CU679109 - Synthetic construct Homo sapiens gateway clone IMAGE:100017884 5' read ITGA5 mRNA.
LF338238 - JP 2014500723-A/145741: Polycomb-Associated Non-Coding RNAs.
LF338239 - JP 2014500723-A/145742: Polycomb-Associated Non-Coding RNAs.
LF338241 - JP 2014500723-A/145744: Polycomb-Associated Non-Coding RNAs.
LF338243 - JP 2014500723-A/145746: Polycomb-Associated Non-Coding RNAs.
MA449611 - JP 2018138019-A/21537: Polycomb-Associated Non-Coding RNAs.
MA446067 - JP 2018138019-A/17993: Polycomb-Associated Non-Coding RNAs.
MA573785 - JP 2018138019-A/145711: Polycomb-Associated Non-Coding RNAs.
MA573788 - JP 2018138019-A/145714: Polycomb-Associated Non-Coding RNAs.
MA573790 - JP 2018138019-A/145716: Polycomb-Associated Non-Coding RNAs.
MA573792 - JP 2018138019-A/145718: Polycomb-Associated Non-Coding RNAs.
MA573793 - JP 2018138019-A/145719: Polycomb-Associated Non-Coding RNAs.
MA573796 - JP 2018138019-A/145722: Polycomb-Associated Non-Coding RNAs.
MA573797 - JP 2018138019-A/145723: Polycomb-Associated Non-Coding RNAs.
MA573799 - JP 2018138019-A/145725: Polycomb-Associated Non-Coding RNAs.
MA573800 - JP 2018138019-A/145726: Polycomb-Associated Non-Coding RNAs.
MA573801 - JP 2018138019-A/145727: Polycomb-Associated Non-Coding RNAs.
MA573803 - JP 2018138019-A/145729: Polycomb-Associated Non-Coding RNAs.
MA573804 - JP 2018138019-A/145730: Polycomb-Associated Non-Coding RNAs.
MA573805 - JP 2018138019-A/145731: Polycomb-Associated Non-Coding RNAs.
MA573807 - JP 2018138019-A/145733: Polycomb-Associated Non-Coding RNAs.
MA573808 - JP 2018138019-A/145734: Polycomb-Associated Non-Coding RNAs.
MA573809 - JP 2018138019-A/145735: Polycomb-Associated Non-Coding RNAs.
MA573811 - JP 2018138019-A/145737: Polycomb-Associated Non-Coding RNAs.
MA573812 - JP 2018138019-A/145738: Polycomb-Associated Non-Coding RNAs.
MA573814 - JP 2018138019-A/145740: Polycomb-Associated Non-Coding RNAs.
MA573815 - JP 2018138019-A/145741: Polycomb-Associated Non-Coding RNAs.
MA573816 - JP 2018138019-A/145742: Polycomb-Associated Non-Coding RNAs.
MA573818 - JP 2018138019-A/145744: Polycomb-Associated Non-Coding RNAs.
MA573820 - JP 2018138019-A/145746: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P08648 (Reactome details) participates in the following event(s):

R-HSA-202723 Integrin alpha5beta1 binds FN1 dimer
R-HSA-374686 L1 interaction with Integrins
R-HSA-2328037 Fibrillin-1 binds integrins
R-HSA-2426259 COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47
R-HSA-4088264 Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1
R-HSA-265424 SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1
R-HSA-2467436 AGRN binds Integrins alphaVbeta1 (Other beta1-containing integrins)
R-HSA-8941332 RUNX2 regulates genes involved in cell migration
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-1566977 Fibronectin matrix formation
R-HSA-8878166 Transcriptional regulation by RUNX2
R-HSA-445144 Signal transduction by L1
R-HSA-1566948 Elastic fibre formation
R-HSA-216083 Integrin cell surface interactions
R-HSA-109582 Hemostasis
R-HSA-1474244 Extracellular matrix organization
R-HSA-212436 Generic Transcription Pathway
R-HSA-373760 L1CAM interactions
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-422475 Axon guidance
R-HSA-74160 Gene expression (Transcription)
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000293379.1, ENST00000293379.2, ENST00000293379.3, ENST00000293379.4, ENST00000293379.5, ENST00000293379.6, ENST00000293379.7, ENST00000293379.8, FNRA, ITA5_HUMAN, ITGA5 , NM_002205, P08648, Q96HA5, uc317ldo.1, uc317ldo.2
UCSC ID: ENST00000293379.9_7
RefSeq Accession: NM_002205.5
Protein: P08648 (aka ITA5_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.