ID:ITAD_HUMAN DESCRIPTION: RecName: Full=Integrin alpha-D; AltName: Full=ADB2; AltName: Full=CD11 antigen-like family member D; AltName: Full=Leukointegrin alpha D; AltName: CD_antigen=CD11d; Flags: Precursor; FUNCTION: Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood- borne pathogens, particulate matter, and senescent erythrocytes from the blood. SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-D associates with beta-2. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Expressed moderately on myelomonocytic cell lines and subsets of peripheral blood leukocytes and strongly on tissue-specialized cells, including macrophages foam cells within atherosclerotic plaques, and on splenic red pulp macrophages. DOMAIN: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. SIMILARITY: Belongs to the integrin alpha chain family. SIMILARITY: Contains 7 FG-GAP repeats. SIMILARITY: Contains 1 VWFA domain. SEQUENCE CAUTION: Sequence=AAB60634.1; Type=Miscellaneous discrepancy;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00092 - von Willebrand factor type A domain PF00357 - Integrin alpha cytoplasmic region PF01839 - FG-GAP repeat PF08441 - Integrin alpha PF13519 - von Willebrand factor type A domain
ModBase Predicted Comparative 3D Structure on Q13349
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
