Human Gene ITGAL (ENST00000356798.11_4) from GENCODE V47lift37
  Description: integrin subunit alpha L, transcript variant 1 (from RefSeq NM_002209.3)
Gencode Transcript: ENST00000356798.11_4
Gencode Gene: ENSG00000005844.19_16
Transcript (Including UTRs)
   Position: hg19 chr16:30,484,063-30,534,506 Size: 50,444 Total Exon Count: 31 Strand: +
Coding Region
   Position: hg19 chr16:30,484,159-30,532,986 Size: 48,828 Coding Exon Count: 31 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:30,484,063-30,534,506)mRNA (may differ from genome)Protein (1170 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ITAL_HUMAN
DESCRIPTION: RecName: Full=Integrin alpha-L; AltName: Full=CD11 antigen-like family member A; AltName: Full=Leukocyte adhesion glycoprotein LFA-1 alpha chain; Short=LFA-1A; AltName: Full=Leukocyte function-associated molecule 1 alpha chain; AltName: CD_antigen=CD11a; Flags: Precursor;
FUNCTION: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-L associates with beta-2.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Leukocytes.
DOMAIN: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
SIMILARITY: Belongs to the integrin alpha chain family.
SIMILARITY: Contains 7 FG-GAP repeats.
SIMILARITY: Contains 1 VWFA domain.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/itgal/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ITGAL
Diseases sorted by gene-association score: benign cephalic histiocytosis (8), leukocyte adhesion deficiency (6), lichen planus (4), rheumatoid arthritis (3), mycosis fungoides (3), guttate psoriasis (3), hashimoto thyroiditis (3), autoimmune enteropathy (3), lymphocytic vasculitis (3), actinic prurigo (2), pustulosis palmaris et plantaris (2), cardiomyopathy (2), chronic lymphocytic leukemia (2), malaria (1), diffuse infiltrative lymphocytosis syndrome (1), penicilliosis (1), leukemia, acute promyelocytic, somatic (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 54.73 RPKM in Whole Blood
Total median expression: 206.37 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -26.4096-0.275 Picture PostScript Text
3' UTR -524.801520-0.345 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013517 - FG-GAP
IPR013519 - Int_alpha_beta-p
IPR000413 - Integrin_alpha
IPR013649 - Integrin_alpha-2
IPR018184 - Integrin_alpha_C_CS
IPR002035 - VWF_A

Pfam Domains:
PF00092 - von Willebrand factor type A domain
PF00357 - Integrin alpha cytoplasmic region
PF01839 - FG-GAP repeat
PF08441 - Integrin alpha
PF13519 - von Willebrand factor type A domain

SCOP Domains:
69179 - Integrin domains
69318 - Integrin alpha N-terminal domain
53300 - vWA-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1CQP - X-ray MuPIT 1DGQ - NMR MuPIT 1IJ4 - Model 1LFA - X-ray MuPIT 1MJN - X-ray MuPIT 1MQ8 - X-ray MuPIT 1MQ9 - X-ray MuPIT 1MQA - X-ray MuPIT 1RD4 - X-ray MuPIT 1T0P - X-ray MuPIT 1XDD - X-ray MuPIT 1XDG - X-ray MuPIT 1XUO - X-ray MuPIT 1ZON - X-ray MuPIT 1ZOO - X-ray MuPIT 1ZOP - X-ray MuPIT 2ICA - X-ray MuPIT 2K8O - NMR MuPIT 2O7N - X-ray MuPIT 3BN3 - X-ray MuPIT 3BQM - X-ray MuPIT 3BQN - X-ray MuPIT 3E2M - X-ray MuPIT 3EOA - X-ray MuPIT 3EOB - X-ray 3F74 - X-ray MuPIT 3F78 - X-ray MuPIT 3HI6 - X-ray MuPIT 3M6F - X-ray MuPIT 3TCX - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P20701
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0030369 ICAM-3 receptor activity
GO:0044877 macromolecular complex binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0050839 cell adhesion molecule binding

Biological Process:
GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:0006909 phagocytosis
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007159 leukocyte cell-cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007165 signal transduction
GO:0007229 integrin-mediated signaling pathway
GO:0030198 extracellular matrix organization
GO:0043113 receptor clustering
GO:0043312 neutrophil degranulation
GO:0050776 regulation of immune response
GO:0050900 leukocyte migration
GO:0098609 cell-cell adhesion

Cellular Component:
GO:0005886 plasma membrane
GO:0008305 integrin complex
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0034687 integrin alphaL-beta2 complex
GO:0035579 specific granule membrane
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AX794822 - Sequence 19 from Patent WO03051924.
AX794826 - Sequence 23 from Patent WO03051924.
AK314246 - Homo sapiens cDNA, FLJ94991, highly similar to Homo sapiens integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) (ITGAL), mRNA.
BC008777 - Homo sapiens integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), mRNA (cDNA clone MGC:1714 IMAGE:3142951), complete cds.
AX794824 - Sequence 21 from Patent WO03051924.
AK298674 - Homo sapiens cDNA FLJ56671 complete cds, highly similar to Integrin alpha-L precursor.
AX794810 - Sequence 7 from Patent WO03051924.
Y00796 - Human mRNA for leukocyte-associated molecule-1 alpha subunit (LFA-1 alpha subunit).
AK303190 - Homo sapiens cDNA FLJ57691 complete cds, highly similar to Integrin alpha-L precursor.
AX794821 - Sequence 18 from Patent WO03051924.
JD025405 - Sequence 6429 from Patent EP1572962.
JD207020 - Sequence 188044 from Patent EP1572962.
JD029251 - Sequence 10275 from Patent EP1572962.
CU679099 - Synthetic construct Homo sapiens gateway clone IMAGE:100020539 5' read ITGAL mRNA.
JD029840 - Sequence 10864 from Patent EP1572962.
JD020193 - Sequence 1217 from Patent EP1572962.
JD029384 - Sequence 10408 from Patent EP1572962.
AX794814 - Sequence 11 from Patent WO03051924.
AX794827 - Sequence 24 from Patent WO03051924.
AX794823 - Sequence 20 from Patent WO03051924.
AX794813 - Sequence 10 from Patent WO03051924.
AX794820 - Sequence 17 from Patent WO03051924.
AX794811 - Sequence 8 from Patent WO03051924.
AX794819 - Sequence 16 from Patent WO03051924.
AX794818 - Sequence 15 from Patent WO03051924.
AX794812 - Sequence 9 from Patent WO03051924.
AX794825 - Sequence 22 from Patent WO03051924.
JD493402 - Sequence 474426 from Patent EP1572962.
JD389096 - Sequence 370120 from Patent EP1572962.
JD189711 - Sequence 170735 from Patent EP1572962.
JD257146 - Sequence 238170 from Patent EP1572962.
JD210824 - Sequence 191848 from Patent EP1572962.
JD131948 - Sequence 112972 from Patent EP1572962.
JD548031 - Sequence 529055 from Patent EP1572962.
JD535815 - Sequence 516839 from Patent EP1572962.
JD453130 - Sequence 434154 from Patent EP1572962.
JD533435 - Sequence 514459 from Patent EP1572962.
JD287273 - Sequence 268297 from Patent EP1572962.
JD493835 - Sequence 474859 from Patent EP1572962.
JD204371 - Sequence 185395 from Patent EP1572962.
JD450926 - Sequence 431950 from Patent EP1572962.
JD158250 - Sequence 139274 from Patent EP1572962.
JD541160 - Sequence 522184 from Patent EP1572962.
JD208531 - Sequence 189555 from Patent EP1572962.
JD329432 - Sequence 310456 from Patent EP1572962.
JD195338 - Sequence 176362 from Patent EP1572962.
JD527284 - Sequence 508308 from Patent EP1572962.
JD364804 - Sequence 345828 from Patent EP1572962.
JD390651 - Sequence 371675 from Patent EP1572962.
JD391911 - Sequence 372935 from Patent EP1572962.
JD551810 - Sequence 532834 from Patent EP1572962.
JD508069 - Sequence 489093 from Patent EP1572962.
JD045080 - Sequence 26104 from Patent EP1572962.
JD278282 - Sequence 259306 from Patent EP1572962.
HZ483118 - JP 2015535430-A/3624: TERMINALLY MODIFIED RNA.
HZ793049 - JP 2016504050-A/4794: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
JC515781 - Sequence 6034 from Patent WO2014113089.
LQ073369 - Sequence 3693 from Patent EP2964234.
JD140170 - Sequence 121194 from Patent EP1572962.
JD481205 - Sequence 462229 from Patent EP1572962.
JD179301 - Sequence 160325 from Patent EP1572962.
JD380874 - Sequence 361898 from Patent EP1572962.
JD380875 - Sequence 361899 from Patent EP1572962.
JD446357 - Sequence 427381 from Patent EP1572962.
JD499242 - Sequence 480266 from Patent EP1572962.
JD376757 - Sequence 357781 from Patent EP1572962.
JD410121 - Sequence 391145 from Patent EP1572962.
JD447034 - Sequence 428058 from Patent EP1572962.
JD177541 - Sequence 158565 from Patent EP1572962.
JD177540 - Sequence 158564 from Patent EP1572962.
JD361182 - Sequence 342206 from Patent EP1572962.
JD366340 - Sequence 347364 from Patent EP1572962.
JD116941 - Sequence 97965 from Patent EP1572962.
JD401914 - Sequence 382938 from Patent EP1572962.
JD401915 - Sequence 382939 from Patent EP1572962.
JD365966 - Sequence 346990 from Patent EP1572962.
JD110997 - Sequence 92021 from Patent EP1572962.
JD247075 - Sequence 228099 from Patent EP1572962.
JD042094 - Sequence 23118 from Patent EP1572962.
JD229912 - Sequence 210936 from Patent EP1572962.
MA646870 - JP 2017113010-A/4794: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
MA734754 - JP 2017140048-A/3624: TERMINALLY MODIFIED RNA.
MA803923 - JP 2018183181-A/4794: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_blymphocytePathway - B Lymphocyte Cell Surface Molecules
h_granulocytesPathway - Adhesion and Diapedesis of Granulocytes
h_monocytePathway - Monocyte and its Surface Molecules
h_ctlPathway - CTL mediated immune response against target cells
h_neutrophilPathway - Neutrophil and Its Surface Molecules
h_lympathway - Adhesion and Diapedesis of Lymphocytes
h_lymphocytePathway - Adhesion Molecules on Lymphocyte
h_thelperPathway - T Helper Cell Surface Molecules
h_LairPathway - Cells and Molecules involved in local acute inflammatory response
h_tcytotoxicPathway - T Cytotoxic Cell Surface Molecules

Reactome (by CSHL, EBI, and GO)

Protein P20701 (Reactome details) participates in the following event(s):

R-HSA-199050 ICAM1-5 bind Integrin alphaLbeta2 (LFA-1)
R-HSA-202718 Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A)
R-HSA-6799350 Exocytosis of specific granule membrane proteins
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-216083 Integrin cell surface interactions
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-6798695 Neutrophil degranulation
R-HSA-8949275 RUNX3 Regulates Immune Response and Cell Migration
R-HSA-1280218 Adaptive Immune System
R-HSA-1474244 Extracellular matrix organization
R-HSA-109582 Hemostasis
R-HSA-168249 Innate Immune System
R-HSA-8878159 Transcriptional regulation by RUNX3
R-HSA-168256 Immune System
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: CD11A, ENST00000356798.1, ENST00000356798.10, ENST00000356798.2, ENST00000356798.3, ENST00000356798.4, ENST00000356798.5, ENST00000356798.6, ENST00000356798.7, ENST00000356798.8, ENST00000356798.9, ITAL_HUMAN, ITGAL , NM_002209, O43746, P20701, Q45H73, Q96HB1, Q9UBC8, uc317zsr.1, uc317zsr.2
UCSC ID: ENST00000356798.11_4
RefSeq Accession: NM_002209.3
Protein: P20701 (aka ITAL_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.