Human Gene ITPKA (ENST00000260386.7_4) from GENCODE V47lift37

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Description: inositol-trisphosphate 3-kinase A (from RefSeq NM_002220.3)
Gencode Transcript: ENST00000260386.7_4
Gencode Gene: ENSG00000137825.11_9
Transcript (Including UTRs)
Position: hg19 chr15:41,786,072-41,795,749 Size: 9,678 Total Exon Count: 7 Strand: +
Coding Region
Position: hg19 chr15:41,786,126-41,795,364 Size: 9,239 Coding Exon Count: 7

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr15:41,786,072-41,795,749)			mRNA (may differ from genome)		Protein (461 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: IP3KA_HUMAN DESCRIPTION: RecName: Full=Inositol-trisphosphate 3-kinase A; EC=2.7.1.127; AltName: Full=Inositol 1,4,5-trisphosphate 3-kinase A; Short=IP3 3-kinase A; Short=IP3K A; Short=InsP 3-kinase A; CATALYTIC ACTIVITY: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate. ENZYME REGULATION: IP3K is activated by calmodulin. SIMILARITY: Belongs to the inositol phosphokinase (IPK) family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl C016403 2,4-dinitrotoluene C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid C026137 3-hydroxyacetanilide C009505 4,4'-diaminodiphenylmethane D000082 Acetaminophen D000643 Ammonium Chloride D002251 Carbon Tetrachloride D002509 Cephaloridine D002794 Choline D002945 Cisplatin D019327 Copper Sulfate D016572 Cyclosporine D003993 Dibutyl Phthalate D004147 Dioxins D005473 Fluoxetine D005492 Folic Acid D007649 Ketamine D008715 Methionine D008727 Methotrexate D010634 Phenobarbital D011794 Quercetin C513635 S-2-pentyl-4-pentynoic hydroxamic acid D026423 S-Nitroso-N-Acetylpenicillamine D012999 Soman D013749 Tetrachlorodibenzodioxin D013759 Tetrahydrocannabinol D014212 Tretinoin D014635 Valproic Acid C076994 perfluorooctane sulfonic acid C006253 pirinixic acid C009495 titanium dioxide

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 40.10 RPKM in Brain - Cortex Total median expression: 267.29 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-34.50	54	-0.639	Picture	PostScript	Text
3' UTR	-150.40	385	-0.391	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR005522 - IPK

Pfam Domains:
PF03770 - Inositol polyphosphate kinase

SCOP Domains:
56104 - SAICAR synthase-like
54427 - NTF2-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1W2C - X-ray MuPIT

1W2D - X-ray MuPIT

1W2F - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on P23677


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000166 nucleotide binding GO:0004683 calmodulin-dependent protein kinase activity GO:0005516 calmodulin binding GO:0005524 ATP binding GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity GO:0016301 kinase activity GO:0016740 transferase activity GO:0048365 Rac GTPase binding Biological Process: GO:0006020 inositol metabolic process GO:0006468 protein phosphorylation GO:0007165 signal transduction GO:0016310 phosphorylation GO:0030036 actin cytoskeleton organization GO:0032958 inositol phosphate biosynthetic process GO:0043647 inositol phosphate metabolic process GO:0048167 regulation of synaptic plasticity GO:0061003 positive regulation of dendritic spine morphogenesis GO:0097062 dendritic spine maintenance Cellular Component: GO:0005829 cytosol GO:0043197 dendritic spine

Descriptions from all associated GenBank mRNAs


	BC026331 - Homo sapiens inositol 1,4,5-trisphosphate 3-kinase A, mRNA (cDNA clone MGC:26387 IMAGE:4792595), complete cds. X54938 - Human mRNA for inositol 1,4,5-triphosphate 3-kinase. AB463780 - Synthetic construct DNA, clone: pF1KB8104, Homo sapiens ITPKA gene for inositol 1,4,5-trisphosphate 3-kinase A, without stop codon, in Flexi system. JD159148 - Sequence 140172 from Patent EP1572962. JD462981 - Sequence 444005 from Patent EP1572962. JD134750 - Sequence 115774 from Patent EP1572962. JD187778 - Sequence 168802 from Patent EP1572962. JD269018 - Sequence 250042 from Patent EP1572962. JD430842 - Sequence 411866 from Patent EP1572962. JD409764 - Sequence 390788 from Patent EP1572962. JD509484 - Sequence 490508 from Patent EP1572962. JD340262 - Sequence 321286 from Patent EP1572962.

Biochemical and Signaling Pathways


	BioCyc Knowledge Library PWY-6358 - superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism PWY-6362 - 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) PWY-6364 - D-myo-inositol (1,3,4)-trisphosphate biosynthesis PWY-6371 - superpathway of inositol phosphate compounds Reactome (by CSHL, EBI, and GO) Protein P23677 (Reactome details) participates in the following event(s): R-HSA-1855153 I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol R-HSA-1483249 Inositol phosphate metabolism R-HSA-1430728 Metabolism

Other Names for This Gene


	Alternate Gene Symbols: ENST00000260386.1, ENST00000260386.2, ENST00000260386.3, ENST00000260386.4, ENST00000260386.5, ENST00000260386.6, IP3KA_HUMAN, ITPKA , NM_002220, P23677, Q8TAN3, uc317gkg.1, uc317gkg.2 UCSC ID: ENST00000260386.7_4 RefSeq Accession: NM_002220.3 Protein: P23677 (aka IP3KA_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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